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Gene Review

Cd38  -  CD38 antigen

Mus musculus

Synonyms: 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, ...
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High impact information on Cd38


Biological context of Cd38

  • We have evaluated the role of the ADP-ribosyl cyclase, CD38, in bone remodeling, a process by which the skeleton is being renewed constantly through the coordinated activity of osteoclasts and osteoblasts [5].
  • In keeping with the antiapoptotic role of insulin signaling, Cd38(-/-) islets were significantly more susceptible to apoptosis compared with islets isolated from littermate controls [6].
  • In the present study, we report altered Ca(2+) homeostasis and reduced responsiveness to insulin, but not glucose, in Cd38(-/-) beta-cells [6].
  • Although I-19 cDNA appears to encode a novel murine protein, its nucleotide sequence and deduced amino acid sequence show approximately 70% homology to the previously reported sequence of human CD38, suggesting that I-19 cDNA encodes either the mouse homologue of CD38 or a closely related protein [7].
  • The existence of a 22-amino acid hydrophobic region located 23 amino acids from the amino terminal of the deduced protein, together with four potential N-linked glycosylation sites, characterize the deduced protein encoded by I-19 cDNA as a typical type II transmembrane glycoprotein [7].

Anatomical context of Cd38


Associations of Cd38 with chemical compounds


Other interactions of Cd38


Analytical, diagnostic and therapeutic context of Cd38

  • Western blot analysis showed that CD38 protein was detected in the aorta isolated from wild-type (CD38(+/+)) mouse, but not from CD38(-/-) mouse [9].
  • By using an HPLC method and adapting the cycling assay developed initially to study endogenous cADPR, we accurately examined the properties of the synaptosomal ADP-ribosyl cyclase [14].


  1. Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo. Partida-Sánchez, S., Cockayne, D.A., Monard, S., Jacobson, E.L., Oppenheimer, N., Garvy, B., Kusser, K., Goodrich, S., Howard, M., Harmsen, A., Randall, T.D., Lund, F.E. Nat. Med. (2001) [Pubmed]
  2. Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: impact on the development of humoral immunity. Partida-Sánchez, S., Goodrich, S., Kusser, K., Oppenheimer, N., Randall, T.D., Lund, F.E. Immunity (2004) [Pubmed]
  3. Spatio-temporal propagation of Ca2+ signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptors. Bruzzone, S., Kunerth, S., Zocchi, E., De Flora, A., Guse, A.H. J. Cell Biol. (2003) [Pubmed]
  4. A murine stromal cell line allows the proliferation of very primitive human CD34++/CD38- progenitor cells in long-term cultures and semisolid assays. Issaad, C., Croisille, L., Katz, A., Vainchenker, W., Coulombel, L. Blood (1993) [Pubmed]
  5. Disordered osteoclast formation and function in a CD38 (ADP-ribosyl cyclase)-deficient mouse establishes an essential role for CD38 in bone resorption. Sun, L., Iqbal, J., Dolgilevich, S., Yuen, T., Wu, X.B., Moonga, B.S., Adebanjo, O.A., Bevis, P.J., Lund, F., Huang, C.L., Blair, H.C., Abe, E., Zaidi, M. FASEB J. (2003) [Pubmed]
  6. Suppressed insulin signaling and increased apoptosis in CD38-null islets. Johnson, J.D., Ford, E.L., Bernal-Mizrachi, E., Kusser, K.L., Luciani, D.S., Han, Z., Tran, H., Randall, T.D., Lund, F.E., Polonsky, K.S. Diabetes (2006) [Pubmed]
  7. Expression cloning of a cDNA encoding a novel murine B cell activation marker. Homology to human CD38. Harada, N., Santos-Argumedo, L., Chang, R., Grimaldi, J.C., Lund, F.E., Brannan, C.I., Copeland, N.G., Jenkins, N.A., Heath, A.W., Parkhouse, R.M. J. Immunol. (1993) [Pubmed]
  8. Molecular cloning and functional expression of bovine spleen ecto-NAD+ glycohydrolase: structural identity with human CD38. Augustin, A., Muller-Steffner, H., Schuber, F. Biochem. J. (2000) [Pubmed]
  9. CD38 gene disruption inhibits the contraction induced by alpha-adrenoceptor stimulation in mouse aorta. Mitsui-Saito, M., Kato, I., Takasawa, S., Okamoto, H., Yanagisawa, T. J. Vet. Med. Sci. (2003) [Pubmed]
  10. Preliminary studies for an immunotherapeutic approach to the treatment of human myeloma using chimeric anti-CD38 antibody. Stevenson, F.K., Bell, A.J., Cusack, R., Hamblin, T.J., Slade, C.J., Spellerberg, M.B., Stevenson, G.T. Blood (1991) [Pubmed]
  11. CD38 induces apoptosis of a murine pro-B leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD glycohydrolase-independent mechanism. Lund, F.E., Muller-Steffner, H., Romero-Ramirez, H., Moreno-García, M.E., Partida-Sánchez, S., Makris, M., Oppenheimer, N.J., Santos-Argumedo, L., Schuber, F. Int. Immunol. (2006) [Pubmed]
  12. Genomic organization and chromosomal localization of the mouse Bp3 gene, a member of the CD38/ADP-ribosyl cyclase family. Dong, C., Willerford, D., Alt, F.W., Cooper, M.D. Immunogenetics (1996) [Pubmed]
  13. Cell surface antigen CD38 identified as ecto-enzyme of NAD glycohydrolase has hyaluronate-binding activity. Nishina, H., Inageda, K., Takahashi, K., Hoshino, S., Ikeda, K., Katada, T. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  14. The CD38-independent ADP-ribosyl cyclase from mouse brain synaptosomes: a comparative study of neonate and adult brain. Ceni, C., Pochon, N., Villaz, M., Muller-Steffner, H., Schuber, F., Baratier, J., De Waard, M., Ronjat, M., Moutin, M.J. Biochem. J. (2006) [Pubmed]
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