The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

crr  -  PTS system glucose-specific transporter...

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of crr

  • Sugar transport by the bacterial phosphotransferase system. Evidence that crr is the structural gene for the Salmonella typhimurium glucose-specific phosphocarrier protein IIIGlc [1].
  • In the present studies, transformed cells that overproduced IIIGlc 2- and 10-fold, respectively, were constructed from a pts+ strain of E. coli and plasmids containing the crr gene [2].
 

High impact information on crr

  • In some crr mutants Factor IIIG1c was not detected, whereas in others it was present at reduced levels [3].
  • The crr gene is closely linked to but not part of the pts operon, and may be a regulatory gene for the operon [3].
  • The inability of crr and also cya mutants to grow on trehalose was due to lowered intracellular cyclic AMP synthesis, since addition of extracellular cyclic AMP restored growth [4].
  • The crr mutation was shown to affect the phosphoenolpyruvate:sugar phosphotransferase system-mediated transient repression of the lac operon, intracellular cAMP levels, and sensitivity to inducer exclusion [5].
  • In both ptsH,I, and crr mutants the amount of galactose binding protein, one of the components of MglP, is only 5%-20% of that in wild-type cells, as measured with a specific antibody [6].
 

Chemical compound and disease context of crr

 

Biological context of crr

  • The defect in pts and crr mutants with respect to MGlP synthesis can be relieved in two ways: by externally added cyclic adenosine 3',5-monophosphate (cAMP) or by a mutation in the cAMP binding protein [6].
  • A 4471 bp region between crr and cysM on the Salmonella typhimurium chromosome (49.5 min) has been sequenced [7].
 

Associations of crr with chemical compounds

  • In contrast, a crr mutation that resulted in the absence of IIIGlc of the glucose PTS prevented growth on trehalose [4].

References

 
WikiGenes - Universities