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Gene Review

Cdh13  -  cadherin 13

Mus musculus

Synonyms: 4932416G01Rik, Cadherin-13, Cdht, H-cadherin, Heart cadherin, ...
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Disease relevance of Cdh13

  • On the basis of the expression of H/T-cadherin in lung metastases of different tumors, we suggest that different tumors can have a differential influence on the expression of endothelial cell surface proteins [1].

High impact information on Cdh13


Biological context of Cdh13

  • Among the 10 selected genes, insulin-like growth factor-binding protein-3, inhibitor of apoptosis protein 1, and cadherin-13 were more frequently expressed in SCC cell lines [4].

Anatomical context of Cdh13


Other interactions of Cdh13

  • Cdh16 was initially described as a truncated cadherin expressed in the adult rabbit kidney [6].
  • We identified T-cadherin as a receptor for the hexameric and high-molecular-weight species of adiponectin but not for the trimeric or globular species [2].

Analytical, diagnostic and therapeutic context of Cdh13

  • METHODS AND RESULTS: In vitro, T-cad homophilic ligation induced arrangement of ECs into a capillary-like network in a 2-dimensional model of EC differentiation and stimulated in-gel endothelial sprout outgrowth in an EC spheroid model and a modified Nicosia tissue assay [5].


  1. Increased expression of H/T-cadherin in tumor-penetrating blood vessels. Wyder, L., Vitaliti, A., Schneider, H., Hebbard, L.W., Moritz, D.R., Wittmer, M., Ajmo, M., Klemenz, R. Cancer Res. (2000) [Pubmed]
  2. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Hug, C., Wang, J., Ahmad, N.S., Bogan, J.S., Tsao, T.S., Lodish, H.F. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Comparative expression patterns of T-, N-, E-cadherins, beta-catenin, and polysialic acid neural cell adhesion molecule in rat cochlea during development: implications for the nature of Kölliker's organ. Simonneau, L., Gallego, M., Pujol, R. J. Comp. Neurol. (2003) [Pubmed]
  4. Gene expression profiling in two morphologically different uterine cervical carcinoma cell lines derived from a single donor using a human cancer cDNA array. Fujimoto, T., Nishikawa, A., Iwasaki, M., Akutagawa, N., Teramoto, M., Kudo, R. Gynecol. Oncol. (2004) [Pubmed]
  5. Atypical GPI-Anchored T-Cadherin Stimulates Angiogenesis In Vitro and In Vivo. Philippova, M., Banfi, A., Ivanov, D., Gianni-Barrera, R., Allenspach, R., Erne, P., Resink, T. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
  6. Kidney-specific cadherin (cdh16) is expressed in embryonic kidney, lung, and sex ducts. Wertz, K., Herrmann, B.G. Mech. Dev. (1999) [Pubmed]
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