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Gene Review

CDH13  -  cadherin 13

Homo sapiens

Synonyms: CDHH, Cadherin-13, H-cadherin, Heart cadherin, P105, ...
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Disease relevance of CDH13

  • Although defective progenitor-stromal adhesion is a well-recognized feature of chronic myeloid leukemia (CML), the role of CDH13 abnormalities has not been evaluated in this disease [1].
  • p16INK4A and CDH13 hypermethylation in tumor and serum of non-small cell lung cancer patients [2].
  • Expression of T-cadherin (CDH13, H-Cadherin) in human brain and its characteristics as a negative growth regulator of epidermal growth factor in neuroblastoma cells [3].
  • Although functional studies are needed to better define the role of CDH13 and CAV1 in the malignant behavior of osteosarcoma cells, the data presented here provide an aid to understanding the biological functions of L/B/K ALP in bone tumors [4].
  • CDH13 protein and mRNA were consistently expressed in all human and murine retinoblastoma compared with normal adult human retina [5].

High impact information on CDH13


Biological context of CDH13


Anatomical context of CDH13


Associations of CDH13 with chemical compounds


Co-localisations of CDH13


Regulatory relationships of CDH13


Other interactions of CDH13

  • Promoter methylation of CDH1 and CDH13 were noted in dual SV40- and EBV-infected PBMC, and these two genes were also highly significantly correlated to the presence of SV40 sequences in tumors [21].
  • Two genes were consistently overexpressed: OKL38 and CDH13 [22].
  • Three genes exhibited higher methylation frequencies in invasive tumors: RASSF1A (30% versus 0%; P = 0.0002), H-cadherin (22% versus 2%; P = 0.013), and APC (22% versus 0%; P = 0.003) [23].
  • Finally, we found a significant association of cirrhosis with hypermethylation of the p16INK4a and hypomethylation of the CDH13 genes [24].
  • Control vector-transfected A549 cells showed a positive band of SP-D but not of T cadherin [9].

Analytical, diagnostic and therapeutic context of CDH13


  1. Cadherin-13, a mediator of calcium-dependent cell-cell adhesion, is silenced by methylation in chronic myeloid leukemia and correlates with pretreatment risk profile and cytogenetic response to interferon alfa. Roman-Gomez, J., Castillejo, J.A., Jimenez, A., Cervantes, F., Boque, C., Hermosin, L., Leon, A., Grañena, A., Colomer, D., Heiniger, A., Torres, A. J. Clin. Oncol. (2003) [Pubmed]
  2. p16INK4A and CDH13 hypermethylation in tumor and serum of non-small cell lung cancer patients. Ulivi, P., Zoli, W., Calistri, D., Fabbri, F., Tesei, A., Rosetti, M., Mengozzi, M., Amadori, D. J. Cell. Physiol. (2006) [Pubmed]
  3. Expression of T-cadherin (CDH13, H-Cadherin) in human brain and its characteristics as a negative growth regulator of epidermal growth factor in neuroblastoma cells. Takeuchi, T., Misaki, A., Liang, S.B., Tachibana, A., Hayashi, N., Sonobe, H., Ohtsuki, Y. J. Neurochem. (2000) [Pubmed]
  4. Identification of candidate genes involved in the reversal of malignant phenotype of osteosarcoma cells transfected with the liver/bone/kidney alkaline phosphatase gene. Zucchini, C., Bianchini, M., Valvassori, L., Perdichizzi, S., Benini, S., Manara, M.C., Solmi, R., Strippoli, P., Picci, P., Carinci, P., Scotlandi, K. Bone (2004) [Pubmed]
  5. Minimal 16q genomic loss implicates cadherin-11 in retinoblastoma. Marchong, M.N., Chen, D., Corson, T.W., Lee, C., Harmandayan, M., Bowles, E., Chen, N., Gallie, B.L. Mol. Cancer Res. (2004) [Pubmed]
  6. H-cadherin, a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer. Lee, S.W. Nat. Med. (1996) [Pubmed]
  7. Intra- and interindividual epigenetic variation in human germ cells. Flanagan, J.M., Popendikyte, V., Pozdniakovaite, N., Sobolev, M., Assadzadeh, A., Schumacher, A., Zangeneh, M., Lau, L., Virtanen, C., Wang, S.C., Petronis, A. Am. J. Hum. Genet. (2006) [Pubmed]
  8. Loss of T-cadherin (CDH13, H-cadherin) expression in cutaneous squamous cell carcinoma. Takeuchi, T., Liang, S.B., Matsuyoshi, N., Zhou, S., Miyachi, Y., Sonobe, H., Ohtsuki, Y. Lab. Invest. (2002) [Pubmed]
  9. T-cadherin (CDH13, H-cadherin) expression downregulated surfactant protein D in bronchioloalveolar cells. Takeuchi, T., Misaki, A., Fujita, J., Sonobe, H., Ohtsuki, Y. Virchows Arch. (2001) [Pubmed]
  10. Expression of T-cadherin in tumor cells influences invasive potential of human hepatocellular carcinoma. Riou, P., Saffroy, R., Chenailler, C., Franc, B., Gentile, C., Rubinstein, E., Resink, T., Debuire, B., Piatier-Tonneau, D., Lemoine, A. FASEB J. (2006) [Pubmed]
  11. Cell adhesion molecule T-cadherin regulates vascular cell adhesion, phenotype and motility. Ivanov, D., Philippova, M., Tkachuk, V., Erne, P., Resink, T. Exp. Cell Res. (2004) [Pubmed]
  12. Frequent promoter methylation and gene silencing of CDH13 in pancreatic cancer. Sakai, M., Hibi, K., Koshikawa, K., Inoue, S., Takeda, S., Kaneko, T., Nakao, A. Cancer Sci. (2004) [Pubmed]
  13. T-cadherin negatively regulates the proliferation of cutaneous squamous carcinoma cells. Mukoyama, Y., Zhou, S., Miyachi, Y., Matsuyoshi, N. J. Invest. Dermatol. (2005) [Pubmed]
  14. Regulation of T-cadherin by hormones, glucocorticoid and EGF. Bromhead, C., Miller, J.H., McDonald, F.J. Gene (2006) [Pubmed]
  15. The glycosyl phosphatidylinositol anchor of human T-cadherin binds lipoproteins. Niermann, T., Kern, F., Erne, P., Resink, T. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  16. Aryl hydrocarbon receptor ligands repress T-cadherin expression in vascular smooth muscle cells. Niermann, T., Schmutz, S., Erne, P., Resink, T. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  17. T-cadherin and signal-transducing molecules co-localize in caveolin-rich membrane domains of vascular smooth muscle cells. Philippova, M.P., Bochkov, V.N., Stambolsky, D.V., Tkachuk, V.A., Resink, T.J. FEBS Lett. (1998) [Pubmed]
  18. T-cadherin expression delineates specific regions of the developing motor axon-hindlimb projection pathway. Fredette, B.J., Ranscht, B. J. Neurosci. (1994) [Pubmed]
  19. T-cadherin protects endothelial cells from oxidative stress-induced apoptosis. Joshi, M.B., Philippova, M., Ivanov, D., Allenspach, R., Erne, P., Resink, T.J. FASEB J. (2005) [Pubmed]
  20. An adiponectin receptor, T-cadherin, was selectively expressed in intratumoral capillary endothelial cells in hepatocellular carcinoma: possible cross talk between T-cadherin and FGF-2 pathways. Adachi, Y., Takeuchi, T., Sonobe, H., Ohtsuki, Y. Virchows Arch. (2006) [Pubmed]
  21. Presence of simian virus 40 DNA sequences in human lymphoid and hematopoietic malignancies and their relationship to aberrant promoter methylation of multiple genes. Shivapurkar, N., Takahashi, T., Reddy, J., Zheng, Y., Stastny, V., Collins, R., Toyooka, S., Suzuki, M., Parikh, G., Asplund, S., Kroft, S.H., Timmons, C., McKenna, R.W., Feng, Z., Gazdar, A.F. Cancer Res. (2004) [Pubmed]
  22. Investigation in liver tissues and cell lines of the transcription of 13 genes mapping to the 16q24 region that are frequently deleted in hepatocellular carcinoma. Riou, P., Saffroy, R., Comoy, J., Gross-Goupil, M., Thiéry, J.P., Emile, J.F., Azoulay, D., Piatier-Tonneau, D., Lemoine, A., Debuire, B. Clin. Cancer Res. (2002) [Pubmed]
  23. Promoter hypermethylation profile of ovarian epithelial neoplasms. Makarla, P.B., Saboorian, M.H., Ashfaq, R., Toyooka, K.O., Toyooka, S., Minna, J.D., Gazdar, A.F., Schorge, J.O. Clin. Cancer Res. (2005) [Pubmed]
  24. Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis. Yu, J., Ni, M., Xu, J., Zhang, H., Gao, B., Gu, J., Chen, J., Zhang, L., Wu, M., Zhen, S., Zhu, J. BMC Cancer (2002) [Pubmed]
  25. Expression of cell adhesion molecule T-cadherin in the human vasculature. Ivanov, D., Philippova, M., Antropova, J., Gubaeva, F., Iljinskaya, O., Tararak, E., Bochkov, V., Erne, P., Resink, T., Tkachuk, V. Histochem. Cell Biol. (2001) [Pubmed]
  26. Polarisation of T-cadherin to the leading edge of migrating vascular cells in vitro: a function in vascular cell motility? Philippova, M., Ivanov, D., Tkachuk, V., Erne, P., Resink, T.J. Histochem. Cell Biol. (2003) [Pubmed]
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