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Gene Review

Cdh13  -  cadherin 13

Rattus norvegicus

Synonyms: Cdht, T-cadherin, Tcad
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Disease relevance of Cdh13

  • We further demonstrate that transient and stable reexpression of T-cadherin in deficient C6 glioma cell lines results in growth suppression [1].
  • Based on recent studies from our laboratory implicating T-cadherin expression in mouse brain tumorigenesis, we examined the role of T-cadherin in astrocytoma growth regulation [1].

High impact information on Cdh13


Biological context of Cdh13


Anatomical context of Cdh13

  • Lastly, T-cadherin-mediated growth arrest was dependent on p21(CIP1/WAF1) expression and was eliminated in p21(CIP1/WAF1)-deficient fibroblasts [1].
  • Here we performed immunohistochemical analysis of spatial and temporal changes in vascular T-cadherin expression following balloon catheterisation of the rat carotid artery [2].
  • Aryl hydrocarbon receptor ligands repress T-cadherin expression in vascular smooth muscle cells [3].
  • Using cultures of rat aortic smooth muscle cells this study presents data revealing T-cadherin as a putative target gene for negative regulation of expression through AHR signalling [3].

Other interactions of Cdh13

  • T-cadherin is a glycosyl phosphatidylinositol-anchored member of the cadherin superfamily of adhesion molecules [2].


  1. T-cadherin-mediated cell growth regulation involves G2 phase arrest and requires p21(CIP1/WAF1) expression. Huang, Z.Y., Wu, Y., Hedrick, N., Gutmann, D.H. Mol. Cell. Biol. (2003) [Pubmed]
  2. Expression of adhesion molecule T-cadherin is increased during neointima formation in experimental restenosis. Kudrjashova, E., Bashtrikov, P., Bochkov, V., Parfyonova, Y., Tkachuk, V., Antropova, J., Iljinskaya, O., Tararak, E., Erne, P., Ivanov, D., Philippova, M., Resink, T.J. Histochem. Cell Biol. (2002) [Pubmed]
  3. Aryl hydrocarbon receptor ligands repress T-cadherin expression in vascular smooth muscle cells. Niermann, T., Schmutz, S., Erne, P., Resink, T. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  4. T-cadherin upregulation correlates with cell-cycle progression and promotes proliferation of vascular cells. Ivanov, D., Philippova, M., Allenspach, R., Erne, P., Resink, T. Cardiovasc. Res. (2004) [Pubmed]
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