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Gene Review

rep  -  replicase

Enterobacteria phage fr

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Disease relevance of rep

  • The greatest divergence between these phages occurs in the 5' terminal region of the A gene, while the lysis-replicase gene overlap, the coat gene and the central region of the replicase gene are highly conserved [1].
  • The operator hairpin ahead of the replicase gene in RNA bacteriophage MS2 contains overlapping signals for binding the coat protein and ribosomes [2].
  • The binding of a coat protein dimer to this hairpin shuts off synthesis of the viral replicase, switching the viral replication cycle to virion assembly rather than continued replication [3].
  • In order to identify proteins translated from those ORFs, gene fusions between the N-terminus of the RNA replicase of the Escherichia coli bacteriophage MS2 and selected regions of ORF4 and ORF6 were constructed [4].
  • Dimers of the capsid protein repress translation of the replicase gene product by binding to the ribosome binding site and this interaction is believed to initiate RNA encapsidation [5].

High impact information on rep


  1. Complete nucleotide sequence of the group I RNA bacteriophage fr. Adhin, M.R., Avots, A., Berzin, V., Overbeek, G.P., van Duin, J. Biochim. Biophys. Acta (1990) [Pubmed]
  2. Forced retroevolution of an RNA bacteriophage. Licis, N., Balklava, Z., Van Duin, J. Virology (2000) [Pubmed]
  3. Crystal structure of an RNA bacteriophage coat protein-operator complex. Valegård, K., Murray, J.B., Stockley, P.G., Stonehouse, N.J., Liljas, L. Nature (1994) [Pubmed]
  4. Identification of gene products of the P1 operon of Mycoplasma pneumoniae. Sperker, B., Hu, P., Herrmann, R. Mol. Microbiol. (1991) [Pubmed]
  5. The crystal structure of bacteriophage Q beta at 3.5 A resolution. Golmohammadi, R., Fridborg, K., Bundule, M., Valegård, K., Liljas, L. Structure (1996) [Pubmed]
  6. Binding of mammalian ribosomes to MS2 phage RNA reveals an overlapping gene encoding a lysis function. Atkins, J.F., Steitz, J.A., Anderson, C.W., Model, P. Cell (1979) [Pubmed]
  7. Mutations that increase the affinity of a translational repressor for RNA. Lim, F., Peabody, D.S. Nucleic Acids Res. (1994) [Pubmed]
  8. The regulatory region of phage fr replicase cistron. III. Initiation activity of specific fr RNA fragments. Berzin, V., Cielens, I., Jansone, I., Gren, E.J. Nucleic Acids Res. (1982) [Pubmed]
  9. CCC.UGA: a new site of ribosomal frameshifting in Escherichia coli. de Smit, M.H., van Duin, J., van Knippenberg, P.H., van Eijk, H.G. Gene (1994) [Pubmed]
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