Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Cenpc1 - centromere protein C1

Mus musculus

Synonyms: CENP-C, CENP-C 1, Cenpc, Centromere autoantigen C, Centromere protein C, ...

Kalitsis, P. et al., Kalitsis, P. et al., Howman, E.V. et al.

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Disease relevance of Cenpc1

Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death [1].

High impact information on Cenpc1

These results suggest that Cenpa is essential for kinetochore targeting of Cenpc and plays an early role in organizing centromeric chromatin at interphase [2].
Centromere protein C (CENPC) is a key protein that has been localized to the inner kinetochore plate of active mammalian centromeres [1].
These results describing the phenotype of the mutant mouse embryos indicate that CENPC has a direct role in the mitotic progression from metaphase to anaphase [1].
Using gene targeting techniques, we have disrupted the mouse Cenpc gene and shown that the gene is essential for normal mouse embryonic development [1].
Cenpag/g embryos assemble functional kinetochores that bind to a host of centromere-specific structural and mitotic spindle checkpoint proteins (Cenpc, BubR1, Mad2 and Zw10) [3].

References

Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death. Kalitsis, P., Fowler, K.J., Earle, E., Hill, J., Choo, K.H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice. Howman, E.V., Fowler, K.J., Newson, A.J., Redward, S., MacDonald, A.C., Kalitsis, P., Choo, K.H. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
Partially functional Cenpa-GFP fusion protein causes increased chromosome missegregation and apoptosis during mouse embryogenesis. Kalitsis, P., Fowler, K.J., Earle, E., Griffiths, B., Howman, E., Newson, A.J., Choo, K.H. Chromosome Res. (2003) [Pubmed]

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