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Gene Review

CENPC  -  centromere protein C

Homo sapiens

Synonyms: CENP-C, CENP-C 1, CENPC1, Centromere autoantigen C, Centromere protein C, ...
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Disease relevance of CENPC1


High impact information on CENPC1


Biological context of CENPC1


Anatomical context of CENPC1


Associations of CENPC1 with chemical compounds


Other interactions of CENPC1

  • In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides [8].
  • CENP-C is a human kinetochore protein that was originally identified as a chromosomal autoantigen in patients with scleroderma spectrum disease [9].
  • Strong reduction of CENP-H resulted in a slightly reduced CENP-C level at the kinetochores and normal localisation of hBubR1, indicating a functional mitotic checkpoint at the hBubR1 protein level [16].
  • Caspase-mediated cleavage of CENP-C and INCENP results in their mislocalization and the subsequent mislocalization of Aurora B kinase [17].
  • In this paper we report that hDaxx and HP1 (which have been shown to interact with CENP-C and Sp100, respectively) are present in a proportion of both ND10 and interphase centromeres [18].

Analytical, diagnostic and therapeutic context of CENPC1


  1. Centromere protein C is a target of autoantibodies in Sjögren's syndrome and is uniformly associated with antibodies to Ro and La. Pillemer, S.R., Casciola-Rosen, L., Baum, B.J., Rosen, A., Gelber, A.C. J. Rheumatol. (2004) [Pubmed]
  2. Human centromere protein C (CENP-C) is a DNA-binding protein which possesses a novel DNA-binding motif. Sugimoto, K., Yata, H., Muro, Y., Himeno, M. J. Biochem. (1994) [Pubmed]
  3. Specific destruction of kinetochore protein CENP-C and disruption of cell division by herpes simplex virus immediate-early protein Vmw110. Everett, R.D., Earnshaw, W.C., Findlay, J., Lomonte, P. EMBO J. (1999) [Pubmed]
  4. Epitope mapping of human centromere autoantigen centromere protein C (CENP-C); heterogeneity of anti-CENP-C response in rheumatic diseases. Sugimoto, K., Kuriyama, K., Himeno, M., Muro, Y. J. Rheumatol. (1998) [Pubmed]
  5. Essential Role for Nuclear PTEN in Maintaining Chromosomal Integrity. Shen, W.H., Balajee, A.S., Wang, J., Wu, H., Eng, C., Pandolfi, P.P., Yin, Y. Cell (2007) [Pubmed]
  6. CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate. Saitoh, H., Tomkiel, J., Cooke, C.A., Ratrie, H., Maurer, M., Rothfield, N.F., Earnshaw, W.C. Cell (1992) [Pubmed]
  7. Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells. Liu, S.T., Rattner, J.B., Jablonski, S.A., Yen, T.J. J. Cell Biol. (2006) [Pubmed]
  8. In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides. Chung, T.L., Hsiao, H.H., Yeh, Y.Y., Shia, H.L., Chen, Y.L., Liang, P.H., Wang, A.H., Khoo, K.H., Shoei-Lung Li, S. J. Biol. Chem. (2004) [Pubmed]
  9. Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator. Pluta, A.F., Earnshaw, W.C. J. Biol. Chem. (1996) [Pubmed]
  10. FISH mapping of centromere protein C (CENPC) on human chromosome 4q31-->q21. Xie, Y., Heng, H.H. Cytogenet. Cell Genet. (1996) [Pubmed]
  11. CENP-B interacts with CENP-C domains containing Mif2 regions responsible for centromere localization. Suzuki, N., Nakano, M., Nozaki, N., Egashira, S., Okazaki, T., Masumoto, H. J. Biol. Chem. (2004) [Pubmed]
  12. Creation and characterization of temperature-sensitive CENP-C mutants in vertebrate cells. Fukagawa, T., Regnier, V., Ikemura, T. Nucleic Acids Res. (2001) [Pubmed]
  13. CENP-C is required for maintaining proper kinetochore size and for a timely transition to anaphase. Tomkiel, J., Cooke, C.A., Saitoh, H., Bernat, R.L., Earnshaw, W.C. J. Cell Biol. (1994) [Pubmed]
  14. Further evidence that CENP-C is a necessary component of active centromeres: studies of a dic(X; 15) with simultaneous immunofluorescence and FISH. Page, S.L., Earnshaw, W.C., Choo, K.H., Shaffer, L.G. Hum. Mol. Genet. (1995) [Pubmed]
  15. Efficient conditional mutation of the vertebrate CENP-C gene. Fukagawa, T., Brown, W.R. Hum. Mol. Genet. (1997) [Pubmed]
  16. RNAi knockdown of human kinetochore protein CENP-H. Orthaus, S., Ohndorf, S., Diekmann, S. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  17. Death Receptor-induced Apoptosis Reveals a Novel Interplay between the Chromosomal Passenger Complex and CENP-C during Interphase. Faragher, A.J., Sun, X.M., Butterworth, M., Harper, N., Mulheran, M., Ruchaud, S., Earnshaw, W.C., Cohen, G.M. Mol. Biol. Cell (2007) [Pubmed]
  18. A dynamic connection between centromeres and ND10 proteins. Everett, R.D., Earnshaw, W.C., Pluta, A.F., Sternsdorf, T., Ainsztein, A.M., Carmena, M., Ruchaud, S., Hsu, W.L., Orr, A. J. Cell. Sci. (1999) [Pubmed]
  19. Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death. Pluta, A.F., Earnshaw, W.C., Goldberg, I.G. J. Cell. Sci. (1998) [Pubmed]
  20. Mutational analysis of the central centromere targeting domain of human centromere protein C, (CENP-C). Song, K., Gronemeyer, B., Lu, W., Eugster, E., Tomkiel, J.E. Exp. Cell Res. (2002) [Pubmed]
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