High impact information on Crygb

• Analysis of tissues and cell lines from mutant animals reveals the presence of extranucleolar foci that contain Fb and Nopp but not other typical nucleolar markers [1].
• The mutant allele Crygbnop (formerly Cat2(nop)) is caused by a replacement of 11 bp by 4 bp in the third exon of Crygb, while a C-->G transversion in exon 3 of Cryge has been found for the Cryget (formerly Cat2(t)) mutation [2].
• Nopp 140 involvement in nucleologenesis of mouse preimplantation embryos [3].
• A detailed stereochemical analysis of the oppositely charged side chains of amino acid residues on the surface of calf eye lens protein gamma-crystallin B has been carried out [4].
• The selective reduced amount of gamma-crystallin specific RNA can be discussed as a biochemical indicator for the histologically observed changes of differentiation in the cataractous Nop lenses [5].

Biological context of Crygb

• The nuclear opacity, provisional gene symbol Nop, is inherited as a single autosomal dominant gene [6].

Associations of Crygb with chemical compounds

• The amount of oxidized glutathione relative to the total amount of glutathione is increased from 2.7 to 7.8% in the Nop/ + mutant (P less than 0.01) [6].

Analytical, diagnostic and therapeutic context of Crygb

• The protein has been shown to be absent in cataractous lenses of Nop /+ mice after isoelectric focusing of water soluble lens proteins [7].

References