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Gene Review

SGPP2  -  sphingosine-1-phosphate phosphatase 2

Homo sapiens

Synonyms: FLJ39004, SPP2, SPPase2, Sphingosine-1-phosphatase 2, Sphingosine-1-phosphate phosphatase 2, ...
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High impact information on SGPP2

  • We propose that SPP-1 and SPP-2 are factors that participate in the recognition of 5' splice sites [1].
  • Together, these results indicate that the chromatin-bound B-subunit in association with origin recognition complex mediates recruiting Polalpha-primase complex onto replication origins in G1 pre-Start through an interaction with primase Spp2/p58 subunit [2].
  • Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2 [3].
  • In this study we have identified a second human S1P phosphohydrolase, SPP2, based on sequence homology to human SPP1 [3].
  • Immunofluorescence microscopic analysis demonstrated that SPP2 is localized to the endoplasmic reticulum [3].

Anatomical context of SGPP2

  • Complexes containing both polypeptides also contained U1 snRNPs, suggesting that SPP-1 and SPP-2 are a part of the functional spliceosome [1].
  • While the SGPP-1 and SGPP-3 transcripts were most abundant in fat body from crowd-reared males, corresponding to significantly higher levels than in isolated-reared males, the SGPP-2 transcript was detected most abundantly in brain from crowd-reared male locusts [4].
  • Furthermore, SGPP-2 transcript levels in brain, testes, fat body, and accessory glands from crowd-reared males significantly exceeded the levels in solitary locusts [4].

Associations of SGPP2 with chemical compounds


  1. Identification of nuclear proteins that specifically bind to RNAs containing 5' splice sites. Stolow, D.T., Berget, S.M. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  2. The B-subunit of DNA polymerase alpha-primase associates with the origin recognition complex for initiation of DNA replication. Uchiyama, M., Wang, T.S. Mol. Cell. Biol. (2004) [Pubmed]
  3. Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2. Ogawa, C., Kihara, A., Gokoh, M., Igarashi, Y. J. Biol. Chem. (2003) [Pubmed]
  4. Transcript profiling of pacifastin-like peptide precursors in crowd- and isolated-reared desert locusts. Simonet, G., Claeys, I., Breugelmans, B., Van Soest, S., De Loof, A., Vanden Broeck, J. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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