Gene Review:
SPP1 - secreted phosphoprotein 1
Homo sapiens
Synonyms:
BNSP, BSPI, Bone sialoprotein 1, ETA-1, Nephropontin, ...
Wang,
Giorgino,
Martemucci,
Carraro,
Javed,
Hota,
Minielli,
Denhardt,
Waller,
Ribatti,
Leali,
Hebert,
Young,
Vaira,
Giannelli,
Lawrence L. K. Leung,
Van Wijnen,
Zhao,
Hassan,
Stein,
Morena,
Rittling,
Gerstenfeld,
Zhang,
Tuck,
Wilson,
Kamal,
Pucci,
Giachelli,
Barnes,
Bellahcene,
Grano,
Presta,
Naldini,
Zallone,
Nico,
Lian,
Timothy Myles,
Colucci,
Hao,
Chambers,
Mori,
- Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells. Barnes, G.L., Javed, A., Waller, S.M., Kamal, M.H., Hebert, K.E., Hassan, M.Q., Bellahcene, A., Van Wijnen, A.J., Young, M.F., Lian, J.B., Stein, G.S., Gerstenfeld, L.C. Cancer Res. (2003)
- Osteopontin induces AP-1-mediated secretion of urokinase-type plasminogen activator through c-Src-dependent epidermal growth factor receptor transactivation in breast cancer cells. Das, R., Mahabeleshwar, G.H., Kundu, G.C. J. Biol. Chem. (2004)
- Osteopontin but not osteonectin messenger RNA expression is a prognostic marker in curatively resected non-small cell lung cancer. Schneider, S., Yochim, J., Brabender, J., Uchida, K., Danenberg, K.D., Metzger, R., Schneider, P.M., Salonga, D., Hölscher, A.H., Danenberg, P.V. Clin. Cancer Res. (2004)
- Expression of bone-related protein messenger RNA in human meningiomas: possible involvement of osteopontin in development of psammoma bodies. Hirota, S., Nakajima, Y., Yoshimine, T., Kohri, K., Nomura, S., Taneda, M., Hayakawa, T., Kitamura, Y. J. Neuropathol. Exp. Neurol. (1995)
- Human myeloma cells express the bone regulating gene Runx2/Cbfa1 and produce osteopontin that is involved in angiogenesis in multiple myeloma patients. Colla, S., Morandi, F., Lazzaretti, M., Rizzato, R., Lunghi, P., Bonomini, S., Mancini, C., Pedrazzoni, M., Crugnola, M., Rizzoli, V., Giuliani, N. Leukemia (2005)
- Plasma osteopontin levels and expression in adipose tissue are increased in obesity. Gómez-Ambrosi, J., Catalán, V., Ramírez, B., Rodríguez, A., Colina, I., Silva, C., Rotellar, F., Mugueta, C., Gil, M.J., Cienfuegos, J.A., Salvador, J., Frühbeck, G. J. Clin. Endocrinol. Metab. (2007)
- Osteopontin and interleukin-8 expression is independently associated with prostate cancer recurrence. Caruso, D.J., Carmack, A.J., Lokeshwar, V.B., Duncan, R.C., Soloway, M.S., Lokeshwar, B.L. Clin. Cancer Res. (2008)
- Activation of the osteopontin/matrix metalloproteinase-9 pathway correlates with prostate cancer progression. Castellano, G., Malaponte, G., Mazzarino, M.C., Figini, M., Marchese, F., Gangemi, P., Travali, S., Stivala, F., Canevari, S., Libra, M. Clin. Cancer Res. (2008)
- Gene expression profiling of paraffin-embedded primary melanoma using the DASL assay identifies increased osteopontin expression as predictive of reduced relapse-free survival. Conway, C., Mitra, A., Jewell, R., Randerson-Moor, J., Lobo, S., Nsengimana, J., Edward, S., Sanders, D.S., Cook, M., Powell, B., Boon, A., Elliott, F., de Kort, F., Knowles, M.A., Bishop, D.T., Newton-Bishop, J. Clin. Cancer Res. (2009)
- Effect of dietary modification on urinary stone risk factors. Pak, C.Y., Odvina, C.V., Pearle, M.S., Sakhaee, K., Peterson, R.D., Poindexter, J.R., Brinkley, L.J. Kidney Int. (2005)
- Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow. You, J., Yellowley, C.E., Donahue, H.J., Zhang, Y., Chen, Q., Jacobs, C.R. Journal of biomechanical engineering. (2000)
- Osteopontin is increased in HIV-associated dementia. Burdo, T.H., Ellis, R.J., Fox, H.S. J. Infect. Dis. (2008)
- Role of osteopontin in cellular signaling and toxicant injury. Denhardt, D.T., Giachelli, C.M., Rittling, S.R. Annu. Rev. Pharmacol. Toxicol. (2001)
- Osteopontin: role in cell signaling and cancer progression. Rangaswami, H., Bulbule, A., Kundu, G.C. Trends Cell Biol. (2006)
- Enhancement of osteopontin expression in HepG2 cells by epidermal growth factor via phosphatidylinositol 3-kinase signaling pathway. Zhang, G.X., Zhao, Z.Q., Wang, H.D., Hao, B. World J. Gastroenterol. (2004)
- Generation and use of recombinant human bone sialoprotein and osteopontin for hydroxyapatite studies. Stubbs, J.T. Connect. Tissue Res. (1996)
- Sequence variants of the secreted phosphoprotein 1 gene are associated with total serum immunoglobulin E levels in a Japanese population. Tanino, Y., Hizawa, N., Konno, S., Fukui, Y., Takahashi, D., Maeda, Y., Huang, S.K., Nishimura, M. Clin. Exp. Allergy (2006)
- Tissue-wide expression profiling using cDNA subtraction and microarrays to identify tumor-specific genes. Amatschek, S., Koenig, U., Auer, H., Steinlein, P., Pacher, M., Gruenfelder, A., Dekan, G., Vogl, S., Kubista, E., Heider, K.H., Stratowa, C., Schreiber, M., Sommergruber, W. Cancer Res. (2004)
- An osteopontin (SPP1) polymorphism is associated with systemic lupus erythematosus. Forton, A.C., Petri, M.A., Goldman, D., Sullivan, K.E. Hum. Mutat. (2002)
- Human marrow stromal cells activate monocytes to secrete osteopontin, which down-regulates Notch1 gene expression in CD34+ cells. Iwata, M., Awaya, N., Graf, L., Kahl, C., Torok-Storb, B. Blood (2004)
- runt homology domain transcription factors (Runx, Cbfa, and AML) mediate repression of the bone sialoprotein promoter: evidence for promoter context-dependent activity of Cbfa proteins. Javed, A., Barnes, G.L., Jasanya, B.O., Stein, J.L., Gerstenfeld, L., Lian, J.B., Stein, G.S. Mol. Cell. Biol. (2001)
- Cutting Edge: IL-1beta Mediates the Proangiogenic Activity of Osteopontin-Activated Human Monocytes. Naldini, A., Leali, D., Pucci, A., Morena, E., Carraro, F., Nico, B., Ribatti, D., Presta, M. J. Immunol. (2006)
- ECC-1 cells: a well-differentiated steroid-responsive endometrial cell line with characteristics of luminal epithelium. Mo, B., Vendrov, A.E., Palomino, W.A., DuPont, B.R., Apparao, K.B., Lessey, B.A. Biol. Reprod. (2006)
- Osteocalcin induces chemotaxis, secretion of matrix proteins, and calcium-mediated intracellular signaling in human osteoclast-like cells. Chenu, C., Colucci, S., Grano, M., Zigrino, P., Barattolo, R., Zambonin, G., Baldini, N., Vergnaud, P., Delmas, P.D., Zallone, A.Z. J. Cell Biol. (1994)
- Age-related changes in human bone proteoglycan structure. Impact of osteogenesis imperfecta. Grzesik, W.J., Frazier, C.R., Shapiro, J.R., Sponseller, P.D., Robey, P.G., Fedarko, N.S. J. Biol. Chem. (2002)
- Bone Sialoprotein Enhances Migration of Bone Marrow Stromal Cells Through Matrices by Bridging MMP-2 to alpha(v)beta(3)-Integrin. Karadag, A., Fisher, L.W. J. Bone Miner. Res. (2006)
- Osteopontin-induced migration of human mammary epithelial cells involves activation of EGF receptor and multiple signal transduction pathways. Tuck, A.B., Hota, C., Wilson, S.M., Chambers, A.F. Oncogene (2003)
- Inhibition of osteoblast differentiation but not adipocyte differentiation of mesenchymal stem cells by sera obtained from aged females. Abdallah, B.M., Haack-Sørensen, M., Fink, T., Kassem, M. Bone (2006)
- Thrombin hydrolysis of human osteopontin is dependent on thrombin anion-binding exosites. Myles, T., Leung, L.L. J. Biol. Chem. (2008)
- Polymeric osteopontin employs integrin alpha9beta1 as a receptor and attracts neutrophils by presenting a de novo binding site. Nishimichi, N., Higashikawa, F., Kinoh, H.H., Tateishi, Y., Matsuda, H., Yokosaki, Y. J. Biol. Chem. (2009)
- Vascular endothelial growth factor and osteopontin in tumor biology. Shijubo, N., Uede, T., Kon, S., Nagata, M., Abe, S. Critical reviews in oncogenesis. (2000)
- Transcriptional activation domains of elk-1, delta elk-1 and SAP-1 proteins. Bhattacharya, G., Lee, L., Reddy, E.S., Rao, V.N. Oncogene (1993)
- HGF and M-CSF modulate adhesion of MDA-231 breast cancer cell by increasing osteopontin secretion. Grano, M., Mori, G., Minielli, V., Colucci, S., Vaira, S., Giannelli, G., Martemucci, S., Giorgino, F., Zallone, A.Z. J. Biol. Regul. Homeost. Agents (2002)
- Specifically modified osteopontin in rheumatoid arthritis fibroblast-like synoviocytes supports interaction with B cells and enhances production of interleukin-6. Take, Y., Nakata, K., Hashimoto, J., Tsuboi, H., Nishimoto, N., Ochi, T., Yoshikawa, H. Arthritis Rheum. (2009)
- Three SIBLINGs (small integrin-binding ligand, N-linked glycoproteins) enhance factor H's cofactor activity enabling MCP-like cellular evasion of complement-mediated attack. Jain, A., Karadag, A., Fohr, B., Fisher, L.W., Fedarko, N.S. J. Biol. Chem. (2002)
- Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone. Fisher, L.W., Hawkins, G.R., Tuross, N., Termine, J.D. J. Biol. Chem. (1987)
- Role of osteopontin in induction of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta through the NF-kappaB and MAPK pathways in rheumatoid arthritis. Zheng, W., Li, R., Pan, H., He, D., Xu, R., Guo, T.B., Guo, Y., Zhang, J.Z. Arthritis Rheum. (2009)
- Proteomics-based validation of genomic data: applications in colorectal cancer diagnosis. Madoz-Gúrpide, J., López-Serra, P., Martínez-Torrecuadrada, J.L., Sánchez, L., Lombardía, L., Casal, J.I. Mol. Cell Proteomics (2006)