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Chemical Compound Review

AC1NSKNC     [(E,2R,3S)-2-amino-3-hydroxy- octadec-4...

Synonyms: CHEMBL311190, Sphingosine 1 Phosphate
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Disease relevance of Sphingosine 1 Phosphate

  • Moreover, radiation-induced oocyte loss in adult wild-type female mice, the event that drives premature ovarian failure and infertility in female cancer patients, was completely prevented by in vivo therapy with sphingosine-1-phosphate [1].
  • Mast cells play a pivotal role in inflammatory and immediate-type allergic reactions by secreting a variety of potent inflammatory mediators, including sphingosine-1-phosphate (S1P) [2].
  • S1P shows synergistic activity with the proinflammatory cytokine TNF, showing both pulmonary edema and mortality at subthreshold S1P doses [3].
  • Specifically, preexposure of mice to subthreshold doses of TNF, which alone induced no lung edema, exacerbated S1P-induced edema and impaired survival [3].
  • Because S1P3-null mice are resistant to S1P-induced pulmonary leakage, either alone or in the presence of TNF, S1P3 antagonism may be useful in protecting epithelial integrity in pulmonary disease [3].

High impact information on Sphingosine 1 Phosphate


Chemical compound and disease context of Sphingosine 1 Phosphate


Biological context of Sphingosine 1 Phosphate


Anatomical context of Sphingosine 1 Phosphate


Associations of Sphingosine 1 Phosphate with other chemical compounds


Gene context of Sphingosine 1 Phosphate


Analytical, diagnostic and therapeutic context of Sphingosine 1 Phosphate


  1. Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. Morita, Y., Perez, G.I., Paris, F., Miranda, S.R., Ehleiter, D., Haimovitz-Friedman, A., Fuks, Z., Xie, Z., Reed, J.C., Schuchman, E.H., Kolesnick, R.N., Tilly, J.L. Nat. Med. (2000) [Pubmed]
  2. Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Mitra, P., Oskeritzian, C.A., Payne, S.G., Beaven, M.A., Milstien, S., Spiegel, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF. Gon, Y., Wood, M.R., Kiosses, W.B., Jo, E., Sanna, M.G., Chun, J., Rosen, H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Cyster, J.G. Annu. Rev. Immunol. (2005) [Pubmed]
  5. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Lee, M.J., Thangada, S., Claffey, K.P., Ancellin, N., Liu, C.H., Kluk, M., Volpi, M., Sha'afi, R.I., Hla, T. Cell (1999) [Pubmed]
  6. Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Petrache, I., Natarajan, V., Zhen, L., Medler, T.R., Richter, A.T., Cho, C., Hubbard, W.C., Berdyshev, E.V., Tuder, R.M. Nat. Med. (2005) [Pubmed]
  7. Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes. Ochi, S., Oda, M., Matsuda, H., Ikari, S., Sakurai, J. J. Biol. Chem. (2004) [Pubmed]
  8. Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes. Singer, I.I., Tian, M., Wickham, L.A., Lin, J., Matheravidathu, S.S., Forrest, M.J., Mandala, S., Quackenbush, E.J. J. Immunol. (2005) [Pubmed]
  9. Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells. Malchinkhuu, E., Sato, K., Horiuchi, Y., Mogi, C., Ohwada, S., Ishiuchi, S., Saito, N., Kurose, H., Tomura, H., Okajima, F. Oncogene (2005) [Pubmed]
  10. A facile enzymatic synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate. Van Veldhoven, P.P., Foglesong, R.J., Bell, R.M. J. Lipid Res. (1989) [Pubmed]
  11. Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors. Meyer zu Heringdorf, D., Lass, H., Kuchar, I., Lipinski, M., Alemany, R., Rümenapp, U., Jakobs, K.H. Eur. J. Pharmacol. (2001) [Pubmed]
  12. Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor. Choi, O.H., Kim, J.H., Kinet, J.P. Nature (1996) [Pubmed]
  13. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Cuvillier, O., Pirianov, G., Kleuser, B., Vanek, P.G., Coso, O.A., Gutkind, S., Spiegel, S. Nature (1996) [Pubmed]
  14. Drought-induced guard cell signal transduction involves sphingosine-1-phosphate. Ng, C.K., Carr, K., McAinsh, M.R., Powell, B., Hetherington, A.M. Nature (2001) [Pubmed]
  15. Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Lee, M.J., Thangada, S., Paik, J.H., Sapkota, G.P., Ancellin, N., Chae, S.S., Wu, M., Morales-Ruiz, M., Sessa, W.C., Alessi, D.R., Hla, T. Mol. Cell (2001) [Pubmed]
  16. The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis. Olivera, A., Mizugishi, K., Tikhonova, A., Ciaccia, L., Odom, S., Proia, R.L., Rivera, J. Immunity (2007) [Pubmed]
  17. The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggering. Prieschl, E.E., Csonga, R., Novotny, V., Kikuchi, G.E., Baumruker, T. J. Exp. Med. (1999) [Pubmed]
  18. Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. Kabashima, K., Haynes, N.M., Xu, Y., Nutt, S.L., Allende, M.L., Proia, R.L., Cyster, J.G. J. Exp. Med. (2006) [Pubmed]
  19. Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction. Bornfeldt, K.E., Graves, L.M., Raines, E.W., Igarashi, Y., Wayman, G., Yamamura, S., Yatomi, Y., Sidhu, J.S., Krebs, E.G., Hakomori, S. J. Cell Biol. (1995) [Pubmed]
  20. Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins. Coursol, S., Fan, L.M., Le Stunff, H., Spiegel, S., Gilroy, S., Assmann, S.M. Nature (2003) [Pubmed]
  21. Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling. Stam, J.C., Michiels, F., van der Kammen, R.A., Moolenaar, W.H., Collard, J.G. EMBO J. (1998) [Pubmed]
  22. Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. Clair, T., Aoki, J., Koh, E., Bandle, R.W., Nam, S.W., Ptaszynska, M.M., Mills, G.B., Schiffmann, E., Liotta, L.A., Stracke, M.L. Cancer Res. (2003) [Pubmed]
  23. Cell cycle control of PDGF-induced Ca(2+) signaling through modulation of sphingolipid metabolism. Fatatis, A., Miller, R.J. FASEB J. (1999) [Pubmed]
  24. PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Sanchez, T., Thangada, S., Wu, M.T., Kontos, C.D., Wu, D., Wu, H., Hla, T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  25. Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members. Limaye, V., Li, X., Hahn, C., Xia, P., Berndt, M.C., Vadas, M.A., Gamble, J.R. Blood (2005) [Pubmed]
  26. Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. Shu, X., Wu, W., Mosteller, R.D., Broek, D. Mol. Cell. Biol. (2002) [Pubmed]
  27. Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. Mandala, S.M., Thornton, R., Galve-Roperh, I., Poulton, S., Peterson, C., Olivera, A., Bergstrom, J., Kurtz, M.B., Spiegel, S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  28. Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors. Jolly, P.S., Bektas, M., Watterson, K.R., Sankala, H., Payne, S.G., Milstien, S., Spiegel, S. Blood (2005) [Pubmed]
  29. Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility. Mettu, P.S., Deng, P.F., Misra, U.K., Gawdi, G., Epstein, D.L., Rao, P.V. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  30. Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. Vogler, R., Sauer, B., Kim, D.S., Schäfer-Korting, M., Kleuser, B. J. Invest. Dermatol. (2003) [Pubmed]
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