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Chemical Compound Review

AG-J-99155     (2-amino-3-hydroxy- octadecoxy)phosphonic acid

Synonyms: CTK4E2360, AR-1D8261, AC1L19F4, AC1Q6S7B, 19794-97-9
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Disease relevance of DHS-1-P


High impact information on DHS-1-P


Biological context of DHS-1-P


Associations of DHS-1-P with other chemical compounds


Gene context of DHS-1-P

  • Cells unable to break down long-chain-base phosphates, due to deletion of DPL1 and LCB3, show a 500-fold increase in PHS-1-P and DHS-1-P levels, grow slowly, and survive a 44 degreesC heat stress 10-fold better than parental cells [9].
  • We have identified YSR2 and YSR3 of Saccharomyces cerevisiae as genes encoding dihydrosphingosine-1-phosphate phophatases which are involved in regulation of sphingolipid metabolism [Mao, Wadleigh, Jenkins, Hannun and Obeid (1997) J. Biol. Chem. 272, 28690-28694] [1].
  • The expression levels of the SPL protein correlated well with the dihydrosphingosine-1-phosphate (DHS1P) lyase activity in most tissues [10].


  1. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. Mao, C., Saba, J.D., Obeid, L.M. Biochem. J. (1999) [Pubmed]
  2. Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. Van Brocklyn, J.R., Lee, M.J., Menzeleev, R., Olivera, A., Edsall, L., Cuvillier, O., Thomas, D.M., Coopman, P.J., Thangada, S., Liu, C.H., Hla, T., Spiegel, S. J. Cell Biol. (1998) [Pubmed]
  3. Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors. Wang, F., Van Brocklyn, J.R., Edsall, L., Nava, V.E., Spiegel, S. Cancer Res. (1999) [Pubmed]
  4. A snc1 endocytosis mutant: phenotypic analysis and suppression by overproduction of dihydrosphingosine phosphate lyase. Grote, E., Vlacich, G., Pypaert, M., Novick, P.J. Mol. Biol. Cell (2000) [Pubmed]
  5. Sphingolipid base metabolism. Stereospecific uptake of proton in the enzymatic conversion of sphinganine 1-phosphate to ethanolamine 1-phosphate. Shimojo, T., Akino, T., Miura, Y., Schroepfer, G.J. J. Biol. Chem. (1976) [Pubmed]
  6. De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. Berdyshev, E.V., Gorshkova, I.A., Usatyuk, P., Zhao, Y., Saatian, B., Hubbard, W., Natarajan, V. Cell. Signal. (2006) [Pubmed]
  7. Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. Berdyshev, E.V., Gorshkova, I.A., Garcia, J.G., Natarajan, V., Hubbard, W.C. Anal. Biochem. (2005) [Pubmed]
  8. Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. Dahm, F., Nocito, A., Bielawska, A., Lang, K.S., Georgiev, P., Asmis, L.M., Bielawski, J., Madon, J., Hannun, Y.A., Clavien, P.A. J. Thromb. Haemost. (2006) [Pubmed]
  9. Analysis of phosphorylated sphingolipid long-chain bases reveals potential roles in heat stress and growth control in Saccharomyces. Skrzypek, M.S., Nagiec, M.M., Lester, R.L., Dickson, R.C. J. Bacteriol. (1999) [Pubmed]
  10. Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5'-phosphate binding domain exposed to the cytosol. Ikeda, M., Kihara, A., Igarashi, Y. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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