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Cyp7b1  -  cytochrome P450, family 7, subfamily b,...

Mus musculus

Synonyms: 25-hydroxycholesterol 7-alpha-hydroxylase, AW261589, Cytochrome P450 7B1, D3Ertd552e, HCT-1, ...
 
 
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High impact information on Cyp7b1

  • Plasma and tissue levels of 25- and 27-hydroxycholesterol, two oxysterol substrates of this enzyme with potent regulatory actions in cultured cells, were markedly elevated in Cyp7b1(-/-) knockout animals [1].
  • Parameters of bile acid metabolism as well as plasma cholesterol and triglyceride levels in male and female Cyp7b1(-/-) mice were normal [1].
  • Here, we show that a mouse hepatic oxysterol 7alpha-hydroxylase is encoded by Cyp7b1, a cytochrome P450 cDNA originally isolated from the hippocampus [2].
  • Similarity to CYP7 and other steroid-metabolizing CYPs may argue that hct-1 (CYP7B) plays a role in steroid metabolism in brain, notable because of the documented ability of brain-derived steroids (neurosteroids) to modulate cognitive function in vivo [3].
  • hct-1 (hippocampal transcript) was detected in a differential screen of a rat hippocampal cDNA library [3].
 

Anatomical context of Cyp7b1

  • Expression of a Cyp7b1 cDNA in cultured cells produces an enzyme with the same biochemical and pharmacological properties as those of the hepatic oxysterol 7alpha-hydroxylase [2].
  • Expression of hct-1 was enriched in the formation but was also detected in rat liver and kidney, though at much lower levels; expression was barely detectable in testis, ovary, and adrenal [3].
 

Associations of Cyp7b1 with chemical compounds

  • A potential decrease in bile acid and steroid biosynthesis was indicated by the decreased expression of Cyp7b1 and Hsd3b4, respectively [4].
 

Other interactions of Cyp7b1

  • This was characterized by a reduced expression of Cyp7b1, and elevation of Cyp7a1 and Cyp8b1 expression [5].
 

Analytical, diagnostic and therapeutic context of Cyp7b1

  • Sequence analysis of rat and mouse hct-1 cDNAs revealed extensive homologies with cytochrome P450s (CYPs), a diverse family of heme-binding monooxygenases that metabolize a range of substrates including steroids, fatty acids, and xenobiotics [3].

References

  1. Disruption of the oxysterol 7alpha-hydroxylase gene in mice. Li-Hawkins, J., Lund, E.G., Turley, S.D., Russell, D.W. J. Biol. Chem. (2000) [Pubmed]
  2. Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA. Schwarz, M., Lund, E.G., Lathe, R., Björkhem, I., Russell, D.W. J. Biol. Chem. (1997) [Pubmed]
  3. A novel cytochrome P450 expressed primarily in brain. Stapleton, G., Steel, M., Richardson, M., Mason, J.O., Rose, K.A., Morris, R.G., Lathe, R. J. Biol. Chem. (1995) [Pubmed]
  4. Gene expression profiles associated with inflammation, fibrosis, and cholestasis in mouse liver after griseofulvin. Gant, T.W., Baus, P.R., Clothier, B., Riley, J., Davies, R., Judah, D.J., Edwards, R.E., George, E., Greaves, P., Smith, A.G. EHP toxicogenomics : journal of the National Institute of Environmental Health Sciences. (2003) [Pubmed]
  5. Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice. Wang, X.J., Chamberlain, M., Vassieva, O., Henderson, C.J., Wolf, C.R. Biochem. J. (2005) [Pubmed]
 
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