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Gene Review

Cyp8b1  -  cytochrome P450, family 8, subfamily b,...

Mus musculus

Synonyms: 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase, 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, CYPVIIIB1, Cyp12, Cytochrome P450 8B1, ...
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High impact information on Cyp8b1

  • The synthesis and excretion of bile acids were found to be dramatically elevated in these mutants, and the expression of 2 key bile acid synthase genes, cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1), was strongly upregulated [1].
  • Feedback regulation of the rate-limiting biosynthetic enzyme cholesterol 7alpha-hydroxylase (CYP7A1) is lost in Cyp8b1(-/-) mice, causing expansion of the bile acid pool and alterations in cholesterol metabolism [2].
  • Disruption of the sterol 12alpha-hydroxylase gene (Cyp8b1) in mice prevents the synthesis of cholate, a primary bile acid, and its metabolites [2].
  • Sterol 12alpha-hydroxylase (Cyp8b1) channels bile acid precursors into CA and maps at chromosome 9 (73 cM) [3].
  • An HNF4alpha binding site was found in the mouse Cyp8b1 promoter that was able to direct HNF4alpha-dependent transcription [4].

Biological context of Cyp8b1

  • Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit [3].

Associations of Cyp8b1 with chemical compounds


  1. Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho. Ito, S., Fujimori, T., Furuya, A., Satoh, J., Nabeshima, Y., Nabeshima, Y. J. Clin. Invest. (2005) [Pubmed]
  2. Cholic acid mediates negative feedback regulation of bile acid synthesis in mice. Li-Hawkins, J., Gåfvels, M., Olin, M., Lund, E.G., Andersson, U., Schuster, G., Björkhem, I., Russell, D.W., Eggertsen, G. J. Clin. Invest. (2002) [Pubmed]
  3. Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit. Sehayek, E., Hagey, L.R., Fung, Y.Y., Duncan, E.M., Yu, H.J., Eggertsen, G., Björkhem, I., Hofmann, A.F., Breslow, J.L. J. Lipid Res. (2006) [Pubmed]
  4. Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha. Inoue, Y., Yu, A.M., Yim, S.H., Ma, X., Krausz, K.W., Inoue, J., Xiang, C.C., Brownstein, M.J., Eggertsen, G., Björkhem, I., Gonzalez, F.J. J. Lipid Res. (2006) [Pubmed]
  5. Critical role of cholic acid for development of hypercholesterolemia and gallstones in diabetic mice. Wang, J., Gåfvels, M., Rudling, M., Murphy, C., Björkhem, I., Einarsson, C., Eggertsen, G. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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