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Gene Review

CYP8B1  -  cytochrome P450, family 8, subfamily B,...

Homo sapiens

Synonyms: 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase, 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, CP8B, CYP12, CYPVIIIB1, ...
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High impact information on CYP8B1


Biological context of CYP8B1


Anatomical context of CYP8B1

  • CYP8B1 in human liver was expressed in the cytoplasm of hepatocytes with an even nonzonal distribution within the liver lobulus [7].

Associations of CYP8B1 with chemical compounds


Other interactions of CYP8B1


Analytical, diagnostic and therapeutic context of CYP8B1


  1. Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor. Ellis, E., Axelson, M., Abrahamsson, A., Eggertsen, G., Thörne, A., Nowak, G., Ericzon, B.G., Björkhem, I., Einarsson, C. Hepatology (2003) [Pubmed]
  2. Differential effects of sterol regulatory binding proteins 1 and 2 on sterol 12 alpha-hydroxylase. SREBP-2 suppresses the sterol 12 alpha-hydroxylase promoter. del Castillo-Olivares, A., Gil, G. J. Biol. Chem. (2002) [Pubmed]
  3. Suppression of cholesterol 7alpha-hydroxylase transcription and bile acid synthesis by an alpha1-antitrypsin peptide via interaction with alpha1-fetoprotein transcription factor. Gerbod-Giannone, M.C., Del Castillo-Olivares, A., Janciauskiene, S., Gil, G., Hylemon, P.B. J. Biol. Chem. (2002) [Pubmed]
  4. Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression. Zhang, M., Chiang, J.Y. J. Biol. Chem. (2001) [Pubmed]
  5. Polymorphism in the coding part of the sterol 12alpha-hydroxylase gene does not explain the marked differences in the ratio of cholic acid and chenodeoxycholic acid in human bile. Abrahamsson, A., Gåfvels, M., Reihnér, E., Björkhem, I., Einarsson, C., Eggertsen, G. Scand. J. Clin. Lab. Invest. (2005) [Pubmed]
  6. Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Gåfvels, M., Olin, M., Chowdhary, B.P., Raudsepp, T., Andersson, U., Persson, B., Jansson, M., Björkhem, I., Eggertsen, G. Genomics (1999) [Pubmed]
  7. Human sterol 12a-hydroxylase (CYP8B1) is mainly expressed in hepatocytes in a homogenous pattern. Wang, J., Greene, S., Eriksson, L.C., Rozell, B., Reihnér, E., Einarsson, C., Eggertsen, G., Gåfvels, M. Histochem. Cell Biol. (2005) [Pubmed]
  8. Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene. Jahan, A., Chiang, J.Y. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  9. Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12alpha-hydroxylase gene (CYP8B1). Yang, Y., Eggertsen, G., Gåfvels, M., Andersson, U., Einarsson, C., Björkhem, I., Chiang, J.Y. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  10. Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes. Ellis, E.C. World J. Gastroenterol. (2006) [Pubmed]
  11. Feedback regulation of bile acid synthesis in human liver: importance of HNF-4alpha for regulation of CYP7A1. Abrahamsson, A., Gustafsson, U., Ellis, E., Nilsson, L.M., Sahlin, S., Björkhem, I., Einarsson, C. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  12. Thyroid hormone suppresses hepatic sterol 12alpha-hydroxylase (CYP8B1) activity and messenger ribonucleic acid in rat liver: failure to define known thyroid hormone response elements in the gene. Andersson, U., Yang, Y.Z., Björkhem, I., Einarsson, C., Eggertsen, G., Gåfvels, M. Biochim. Biophys. Acta (1999) [Pubmed]
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