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Gene Review

DCBLD2  -  discoidin, CUB and LCCL domain containing 2

Homo sapiens

Synonyms: CLCP1, CUB, LCCL and coagulation factor V/VIII-homology domains protein 1, Discoidin, CUB and LCCL domain-containing protein 2, ESDN, Endothelial and smooth muscle cell-derived neuropilin-like protein
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Disease relevance of DCBLD2


High impact information on DCBLD2

  • Northern blot analysis showed that ESDN mRNA was expressed in various tissues; particularly highly expressed in cultured vascular smooth muscle cells [2].
  • A novel cDNA has been isolated from primary culture of human coronary arterial cells by a signal sequence trap method, and designated ESDN (endothelial and smooth muscle cell-derived neuropilin-like molecule) [2].
  • Overexpression of ESDN in 293T cells suppressed their bromodeoxyuridine uptake [2].
  • Thus, ESDN is considered to play a role in regulation of vascular cell growth and may have a wide variety of functions in other tissues including the nervous system, like neuropilins [2].
  • The ESDN expression was up-regulated in platelet-derived growth factor-BB-stimulated vascular smooth muscle cells in vitro and neointima of the balloon-injured carotid artery in vivo [2].

Anatomical context of DCBLD2

  • The number of CLCP molecules adsorbed per yeast cell and the loss of colony-forming units are described by an exponential relationship [3].
  • Human neutrophils contain a chymotrypsin-like cationic protein (CLCP) that binds to the surface of Candida parapsilosis and is preferentially adsorbed by yeasts mixed with unfractionated extracts of neutrophil granules [3].

Associations of DCBLD2 with chemical compounds

  • Irreversible inhibition of the enzymatic site of CLCP by phenylmethylsulfonylfluoride or N-acetyl-Ala-Ala-Phe-chloromethyl ketone did not affect its adsorption by yeast [3].

Regulatory relationships of DCBLD2


  1. Significant up-regulation of a novel gene, CLCP1, in a highly metastatic lung cancer subline as well as in lung cancers in vivo. Koshikawa, K., Osada, H., Kozaki, K., Konishi, H., Masuda, A., Tatematsu, Y., Mitsudomi, T., Nakao, A., Takahashi, T. Oncogene (2002) [Pubmed]
  2. ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury. Kobuke, K., Furukawa, Y., Sugai, M., Tanigaki, K., Ohashi, N., Matsumori, A., Sasayama, S., Honjo, T., Tashiro, K. J. Biol. Chem. (2001) [Pubmed]
  3. Fungicidal properties of a chymotrypsin-like cationic protein from human neutrophils: adsorption to Candida parapsilosis. Drazin, R.E., Lehrer, R.I. Infect. Immun. (1977) [Pubmed]
  4. CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells. Nagai, H., Sugito, N., Matsubara, H., Tatematsu, Y., Hida, T., Sekido, Y., Nagino, M., Nimura, Y., Takahashi, T., Osada, H. Oncogene (2007) [Pubmed]
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