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Adam28  -  a disintegrin and metallopeptidase domain 28

Mus musculus

Synonyms: ADAM 28, C130072N01Rik, D430033C21Rik, Disintegrin and metalloproteinase domain-containing protein 28, Dtgn1, ...
 
 
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High impact information on Adam28

  • Furthermore, adhesion of various cell lines to MDC-L correlated with expression of the integrin alpha(4)-subunit [1].
  • These results suggest a potential role for the lymphocyte ADAM, MDC-L, in the interaction of lymphocytes with alpha(4)beta(1)-expressing leukocytes [1].
  • Adhesion of Jurkat cells to the MDC-L disintegrin domain was specifically inhibited by anti-alpha(4) and anti-beta(1) function-blocking mAbs [1].
  • We report here that the disintegrin domain of MDC-L is recognized by the leukocyte integrin alpha(4)beta(1) [1].
  • Several novel genes with putative involvement in epididymal sperm maturation, such as a disintegrin and metallopeptidase domain 28 (Adam28) and a solute carrier organic anion transporter family, member 4C1 (Slco4c1), were identified, indicating that this approach is successful for identifying novel epididymal genes [2].
 

Biological context of Adam28

 

Anatomical context of Adam28

  • Additionally, recognition of the MDC-L disintegrin domain required "activation" of lymphocyte beta(1) integrins [1].
  • Recombinant Fc fusion proteins possessing the disintegrin domain of MDC-L supported adhesion of the T-lymphoma cell line, Jurkat, in a concentration- and divalent cation-dependent manner [1].

References

  1. The lymphocyte metalloprotease MDC-L (ADAM 28) is a ligand for the integrin alpha4beta1. Bridges, L.C., Tani, P.H., Hanson, K.R., Roberts, C.M., Judkins, M.B., Bowditch, R.D. J. Biol. Chem. (2002) [Pubmed]
  2. Differential endocrine regulation of genes enriched in initial segment and distal caput of the mouse epididymis as revealed by genome-wide expression profiling. Sipilä, P., Pujianto, D.A., Shariatmadari, R., Nikkilä, J., Lehtoranta, M., Huhtaniemi, I.T., Poutanen, M. Biol. Reprod. (2006) [Pubmed]
  3. Genomic organization of the region spanning D14Mit262 and D14Mit86 on mouse chromosome 14 and exclusion of Adam28 and Adamdec1 as the cataract-causing gene, lr2. Kim, E., Rhee, S.D., Bae, Y., Okumoto, M., Yoon, J.B., Song, C.W., Yoon, S.K. Cytogenet. Genome Res. (2007) [Pubmed]
 
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