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Gene Review

CPA2  -  carboxypeptidase A2 (pancreatic)

Homo sapiens

Synonyms: Carboxypeptidase A2
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Disease relevance of CPA2


High impact information on CPA2

  • SUBJECTS AND DESIGN: Forty-eight hyperandrogenic women were prospectively randomized to the following treatments for 1 year: CPA 2 mg with 35 micro g ethinylestradiol; CPA 50 mg with 25 micro g ethinylestradiol (reverse sequential regimen); flutamide 250 mg daily; and finasteride 5 mg daily [3].
  • The kinetic data show that hCPA2 has a larger substrate binding site than the hCPA1 enzyme [4].
  • On the other hand, amino terminal sequences of the isoenzymes were found to be 79% and 87% homologous with CAP1 and CPA2 of the rat, respectively [5].

Associations of CPA2 with chemical compounds

  • Purified hCPA1 and hCPA2 migrate as a single protein band with M(r) 34,000 when subjected to gel electrophoresis in the presence of sodium dodecyl sulfate under reducing conditions [4].

Other interactions of CPA2

  • CPA5 expression levels were too low to allow reliable evaluation of allelic expression, while CPA1 and CPA2 both showed biallelic expression [6].


  1. Molecular characterization of tomato-infecting begomoviruses in Thailand. Sawangjit, S., Chatchawankanphanich, O., Chiemsombat, P., Attathom, T., Dale, J., Attathom, S. Virus Res. (2005) [Pubmed]
  2. Myopericarditis caused by cyclophosphamide used to mobilize peripheral blood stem cells in a myeloma patient with renal failure. Yamamoto, R., Kanda, Y., Matsuyama, T., Oshima, K., Nannya, Y., Suguro, M., Chizuka, A., Hamaki, T., Takezako, N., Miwa, A., Kami, M., Mori, S., Kojima, T., Saito, K., Itaoka, Y., Kashida, M. Bone Marrow Transplant. (2000) [Pubmed]
  3. A comparison of the relative efficacy of antiandrogens for the treatment of acne in hyperandrogenic women. Carmina, E., Lobo, R.A. Clin. Endocrinol. (Oxf) (2002) [Pubmed]
  4. Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2. Laethem, R.M., Blumenkopf, T.A., Cory, M., Elwell, L., Moxham, C.P., Ray, P.H., Walton, L.M., Smith, G.K. Arch. Biochem. Biophys. (1996) [Pubmed]
  5. Separation of human pancreatic carboxypeptidase A isoenzymes by high performance liquid chromatography. Linder, D., Linder, M., Schade, H., Sziegoleit, A. Biomed. Chromatogr. (1993) [Pubmed]
  6. The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome. Bentley, L., Nakabayashi, K., Monk, D., Beechey, C., Peters, J., Birjandi, Z., Khayat, F.E., Patel, M., Preece, M.A., Stanier, P., Scherer, S.W., Moore, G.E. J. Med. Genet. (2003) [Pubmed]
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