Gene Review:
Eif2ak3 - eukaryotic translation initiation factor 2...
Mus musculus
Synonyms:
AI427929, Eukaryotic translation initiation factor 2-alpha kinase 3, PERK, PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, ...
- PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver. Li, Y., Iida, K., O'Neil, J., Zhang, P., Li, S., Frank, A., Gabai, A., Zambito, F., Liang, S.H., Rosen, C.J., Cavener, D.R. Endocrinology (2003)
- PERK is responsible for the increased phosphorylation of eIF2alpha and the severe inhibition of protein synthesis after transient global brain ischemia. Owen, C.R., Kumar, R., Zhang, P., McGrath, B.C., Cavener, D.R., Krause, G.S. J. Neurochem. (2005)
- Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Harding, H.P., Zeng, H., Zhang, Y., Jungries, R., Chung, P., Plesken, H., Sabatini, D.D., Ron, D. Mol. Cell (2001)
- Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress. Blais, J.D., Addison, C.L., Edge, R., Falls, T., Zhao, H., Wary, K., Koumenis, C., Harding, H.P., Ron, D., Holcik, M., Bell, J.C. Mol. Cell. Biol. (2006)
- Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition. Jiang, H.Y., Wek, R.C. J. Biol. Chem. (2005)
- Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Jiang, H.Y., Wek, S.A., McGrath, B.C., Lu, D., Hai, T., Harding, H.P., Wang, X., Ron, D., Cavener, D.R., Wek, R.C. Mol. Cell. Biol. (2004)
- The double-stranded RNA-activated protein kinase PKR is dispensable for regulation of translation initiation in response to either calcium mobilization from the endoplasmic reticulum or essential amino acid starvation. Kimball, S.R., Clemens, M.J., Tilleray, V.J., Wek, R.C., Horetsky, R.L., Jefferson, L.S. Biochem. Biophys. Res. Commun. (2001)