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Gene Review

CR1L  -  complement component (3b/4b) receptor 1-like

Homo sapiens

Synonyms: Complement C4b-binding protein CR-1-like protein, Complement component receptor 1-like protein
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High impact information on CR1L

  • Units of duplication range from single SCRs, to septamers such as efbkdaj, to extensive segments such as MCP-CR1L [1].
  • This study examines the effects of duplication and insertions-deletions (indels) by comparing human complement receptor 1 (CR1) and human CR1-like (CR1L) with syntenic genes from four other vertebrates (chimpanzee, baboon, rat, and mouse) [2].
  • However, northern blot analysis of various other lymphoid tissue identified a candidate CR1L transcript in human fetal liver [3].
  • Expression in COS-7 cells yielded a human CR1L protein of approximately 50 kDa that exhibited binding specificity for iC4 but not for iC3 [3].
  • Neither northern nor western blot analysis of human bone marrow revealed the presence of the CR1L transcript or protein [3].

Biological context of CR1L

  • Human CR1L was previously identified from genomic clones that predict exons for seven SCRs, and there have been no reports of CR1L expression [3].

Anatomical context of CR1L

  • Thus, expression of the CR1L transcript appears to be limited to hematopoietic and fetal lymphoid tissue [3].
  • PCR amplification of a cDNA panel of human fetal tissue confirmed the presence of the CR1L transcript in fetal liver, and to a lesser extent in fetal spleen and thymus [3].

Other interactions of CR1L

  • The degeneration of the g SCR must have occurred prior to the formation of primate CR1L and prior to the duplication events which resulted in primate CR1 [4].
  • The first 6.5 SCRs matched 100% with the predicted human CR1L sequence, while the second half of SCR 7 was homologous to the comparable chimp CR1L sequence but with a stop codon [3].


  1. Amino acid patterns within short consensus repeats define conserved duplicons shared by genes of the RCA complex. McLure, C.A., Dawkins, R.L., Williamson, J.F., Davies, R.A., Berry, J., Natalie, L.J., Laird, R., Gaudieri, S. J. Mol. Evol. (2004) [Pubmed]
  2. Indels and imperfect duplication have driven the evolution of human Complement Receptor 1 (CR1) and CR1-like from their precursor CR1 alpha: importance of functional sets. McLure, C.A., Williamson, J.F., Stewart, B.J., Keating, P.J., Dawkins, R.L. Hum. Immunol. (2005) [Pubmed]
  3. A human CR1-like transcript containing sequence for a binding protein for iC4 is expressed in hematopoietic and fetal lymphoid tissue. Logar, C.M., Chen, W., Schmitt, H., Yu, C.Y., Birmingham, D.J. Mol. Immunol. (2004) [Pubmed]
  4. Genomic analysis reveals a duplication of eight rather than seven short consensus repeats in primate CR1 and CR1L: evidence for an additional set shared between CR1 and CR2. McLure, C.A., Williamson, J.F., Stewart, B.J., Keating, P.J., Dawkins, R.L. Immunogenetics (2004) [Pubmed]
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