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Gene Review

Nr2f6  -  nuclear receptor subfamily 2, group F,...

Mus musculus

Synonyms: AV090102, COUP transcription factor 3, COUP-TF3, EAR-2, EAR2, ...
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High impact information on Nr2f6

  • The orphan nuclear receptor Ear2 (Nr2f6) is transiently expressed in the rostral part of the rhombic lip in which the locus coeruleus (LC) arises [1].
  • Overexpression of Ear-2 can prevent G-CSF-induced differentiation, strongly suggesting that ear-2 is a key negative regulator of granulocytic differentiation [2].
  • Our results indicate that a dynamic balance existing between PEBP2alphaB and Ear-2 appears to determine the choice between growth or differentiation for myeloid cells [2].
  • Using this approach, we isolated clones encoding the orphan nuclear receptors chicken ovalbumin upstream promoter-transcription factor (COUP-TF) 2 and COUP-TF3 [3].
  • Here we demonstrate that ARP1 and Ear2 form heterodimers in solution and on directly repeated response elements with high efficiency and a specificity differing from that of homodimeric complexes composed of either receptor [4].

Biological context of Nr2f6

  • To better understand their role in the differentiated adult rat pituitary gland, we cloned COUP-TFII and EAR-2 cDNAs from an anterior pituitary cDNA library [5].

Anatomical context of Nr2f6


Associations of Nr2f6 with chemical compounds


Other interactions of Nr2f6


  1. Abnormal development of the locus coeruleus in Ear2(Nr2f6)-deficient mice impairs the functionality of the forebrain clock and affects nociception. Warnecke, M., Oster, H., Revelli, J.P., Alvarez-Bolado, G., Eichele, G. Genes Dev. (2005) [Pubmed]
  2. Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up, and a chimeric leukemogenic gene, AML1/ETO. Ahn, M.Y., Huang, G., Bae, S.C., Wee, H.J., Kim, W.Y., Ito, Y. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. Friend of GATA 2 physically interacts with chicken ovalbumin upstream promoter-TF2 (COUP-TF2) and COUP-TF3 and represses COUP-TF2-dependent activation of the atrial natriuretic factor promoter. Huggins, G.S., Bacani, C.J., Boltax, J., Aikawa, R., Leiden, J.M. J. Biol. Chem. (2001) [Pubmed]
  4. Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2. Avram, D., Ishmael, J.E., Nevrivy, D.J., Peterson, V.J., Lee, S.H., Dowell, P., Leid, M. J. Biol. Chem. (1999) [Pubmed]
  5. Cloning, expression and regulation of chicken ovalbumin upstream promoter transcription factors (COUP-TFII and EAR-2) in the rat anterior pituitary gland. Raccurt, M., Smallwood, S., Mertani, H.C., Devost, D., Abbaci, K., Boutin, J.M., Morel, G. Neuroendocrinology (2005) [Pubmed]
  6. Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors. Jonk, L.J., de Jonge, M.E., Pals, C.E., Wissink, S., Vervaart, J.M., Schoorlemmer, J., Kruijer, W. Mech. Dev. (1994) [Pubmed]
  7. Math1 Target Genes Are Enriched With Evolutionarily Conserved Clustered E-box Binding Sites. Krizhanovsky, V., Soreq, L., Kliminski, V., Ben-Arie, N. J. Mol. Neurosci. (2006) [Pubmed]
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