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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NEK7  -  NIMA-related kinase 7

Homo sapiens

Synonyms: Never in mitosis A-related kinase 7, NimA-related protein kinase 7, Serine/threonine-protein kinase Nek7
 
 
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High impact information on NEK7

  • Nek6, Nek7 and Nek9 also seem to regulate mitosis [1].
  • Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression [2].
  • Down-regulation of Nek7 using a small interfering RNA approach resulted in a significant increase in mitotic cells presenting multipolar spindle phenotype [2].
  • We describe here the isolation of two novel murine protein kinase genes, designated nek6 and nek7, which are highly similar to each other (87% amino acid identity in the predicted kinase domain) [3].
  • Using a mouse/hamster radiation hybrid panel, we assigned the nek7 gene to chromosome 1 at approximately 73 cM [3].
 

Biological context of NEK7

 

Anatomical context of NEK7

  • NEK7 expression was restricted to a subset of tissues containing lung, muscle, testis, brain, heart, liver, leukocyte, and spleen, but NEK6 transcripts were detected in all tissues studied [4].

References

  1. Caught Nek-ing: cilia and centrioles. Quarmby, L.M., Mahjoub, M.R. J. Cell. Sci. (2005) [Pubmed]
  2. Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression. Yissachar, N., Salem, H., Tennenbaum, T., Motro, B. FEBS Lett. (2006) [Pubmed]
  3. Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA. Kandli, M., Feige, E., Chen, A., Kilfin, G., Motro, B. Genomics (2000) [Pubmed]
  4. Identification and assignment of the human NIMA-related protein kinase 7 gene (NEK7) to human chromosome 1q31.3. Kimura, M., Okano, Y. Cytogenet. Cell Genet. (2001) [Pubmed]
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