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Gene Review

NEK7  -  NIMA-related kinase 7

Homo sapiens

Synonyms: Never in mitosis A-related kinase 7, NimA-related protein kinase 7, Serine/threonine-protein kinase Nek7
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High impact information on NEK7

  • Nek6, Nek7 and Nek9 also seem to regulate mitosis [1].
  • Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression [2].
  • Down-regulation of Nek7 using a small interfering RNA approach resulted in a significant increase in mitotic cells presenting multipolar spindle phenotype [2].
  • We describe here the isolation of two novel murine protein kinase genes, designated nek6 and nek7, which are highly similar to each other (87% amino acid identity in the predicted kinase domain) [3].
  • Using a mouse/hamster radiation hybrid panel, we assigned the nek7 gene to chromosome 1 at approximately 73 cM [3].

Biological context of NEK7


Anatomical context of NEK7

  • NEK7 expression was restricted to a subset of tissues containing lung, muscle, testis, brain, heart, liver, leukocyte, and spleen, but NEK6 transcripts were detected in all tissues studied [4].


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