Disease relevance of Fem1b

• In conclusion, these data implicate Fem1b in pancreatic islet function and insulin secretion, strengthening evidence that a genetic pathway homologous to nematode sex determination may be involved in glucose homeostasis and suggesting novel genes and processes as potential candidates in the pathogenesis of diabetes mellitus [1].

High impact information on Fem1b

• Abnormal glucose homeostasis and pancreatic islet function in mice with inactivation of the Fem1b gene [1].
• The Fem1b gene is expressed in pancreatic islets, within both beta cells and non-beta cells, and is highly expressed in INS-1E cells, a pancreatic beta-cell line [1].
• We studied FEM1B expression in the rodent testis and found that Fem1b mRNA is present at high levels during meiosis and after, during spermiogenesis, in a similar manner to Phtf1 mRNA [2].
• Homologs of fem-1 in mammals have been characterized, consisting of two family members, Fem1a and Fem1b [3].
• The Fem1b gene localizes to chromosome 9 and is highly expressed in adult testis [4].

Other interactions of Fem1b

• This gene family consists of two known members, designated Fem1a and Fem1b [4].

References