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Ppm1g  -  protein phosphatase 1G (formerly 2C),...

Mus musculus

Synonyms: AI385652, FIN13, Fibroblast growth factor-inducible protein 13, Fin13, PP2C-gamma, ...
 
 
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High impact information on Ppm1g

  • Thus, overexpression and/or unregulated expression of FIN13 inhibits cell cycle progression, indicating that the physiological role of this phosphatase may be that of regulating the orderly progression of cells through the mitotic cycle by dephosphorylating specific substrates which are important for cell proliferation [1].
  • In transiently transfected cells, FIN13 inhibits DNA synthesis and results in the accumulation of cells in G1 and early S phases [1].
  • Cotransfection of FIN13-expressing plasmids with a plasmid that expresses the neomycin resistance gene inhibits the growth of drug-resistant colonies in NIH 3T3, HeLa and Rat-1 cells [1].
  • We have identified a novel type 2C serine-threonine phosphatase, FIN13, whose expression is induced by fibroblast growth factor 4 and serum in late G1 phase [1].
  • Similarly, the induction of expression of FIN13 under the control of a tetracycline-regulated promoter in NIH 3T3 cells leads to growth inhibition, with accumulation of cells in G1 and early S phases [1].
 

Biological context of Ppm1g

 

Anatomical context of Ppm1g

 

Associations of Ppm1g with chemical compounds

References

  1. FIN13, a novel growth factor-inducible serine-threonine phosphatase which can inhibit cell cycle progression. Guthridge, M.A., Bellosta, P., Tavoloni, N., Basilico, C. Mol. Cell. Biol. (1997) [Pubmed]
  2. Genomic organization and functional analysis of the murine protein phosphatase 1c gamma (Ppp1cc) gene. Okano, K., Heng, H., Trevisanato, S., Tyers, M., Varmuza, S. Genomics (1997) [Pubmed]
  3. Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences. Croci, C., Sticht, H., Brandstätter, J.H., Enz, R. J. Biol. Chem. (2003) [Pubmed]
 
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