Disease relevance of Retinal Bipolar Cells

• We examined the role of glutamate uptake in the synaptic transmission of graded responses from newt retinal bipolar cells (BCs) to ganglion layer cells (GLCs) [1].

High impact information on Retinal Bipolar Cells

• The retinal bipolar cell receiving glutamate transmission from photoreceptors mediates a key process in segregating visual signals into ON center and OFF center pathways [2].
• Pharmacology of GABA receptor Cl- channels in rat retinal bipolar cells [3].
• Dark noise in retinal bipolar cells and stability of rhodopsin in rods [4].
• Cannabinoid receptor agonists induced a dramatic reduction in the amplitude of voltage-gated L-type calcium channel currents in identified retinal bipolar cells [5].
• The metabotropic receptor mGluR6 may signal through G(o), but not phosphodiesterase, in retinal bipolar cells [6].

Biological context of Retinal Bipolar Cells

• The change in kinetics induced by picrotoxin was also observed on receptors formed by other GABA rho subunits, as well as on the GABA(C) receptors of retinal bipolar cells [7].
• Inhibition of calcium signaling in terminal and soma of carp retinal bipolar cells by GABA [8].

Anatomical context of Retinal Bipolar Cells

• Exocytosis-mediated glutamate release from ribbon-type synaptic terminals of retinal bipolar cells was studied using AMPA receptors and simultaneous membrane capacitance measurements [9].
• Differential reinnervation of retinal bipolar cell dendrites and axon terminals by dopamine interplexiform cells following dopamine depletion with 6-OHDA [10].

Associations of Retinal Bipolar Cells with chemical compounds

• L-glutamate-induced responses and cGMP-activated channels in three subtypes of retinal bipolar cells dissociated from the cat [11].
• Suppression of voltage-dependent K+ currents in retinal bipolar cells by ascorbate [12].
• Caffeine-sensitive Ca2+ stores in carp retinal bipolar cells [13].
• Intracellular cesium separates two glutamate conductances in retinal bipolar cells of goldfish [14].
• Bullfrog retinal bipolar cells may express heterogeneous glycine receptors at dendrites and axon terminals [15].

Gene context of Retinal Bipolar Cells

• Therefore, CHX10 and VSX1 may control retinal bipolar cell specification or differentiation by repressing genes required for the development of other cell types [16].
• This model will be useful in defining the role of nyctalopin in signal transmission between photoreceptors and retinal bipolar cells [17].
• Purkinje cell protein 2 (Pcp2/L7) expression is highly restricted to Purkinje and retinal bipolar cells, where it has been exploited to enable highly specific, Cre recombinase-mediated, site-specific recombination [18].
• We investigated the expression of Ggamma13, a recently discovered G protein subunit, and a selection of Gbeta subunits in retinal bipolar cells, by using a transgenic mouse strain in which green fluorescent protein is strongly expressed in a single type of cone bipolar cell [19].
• METHODS: Two patients with MAR syndrome whose sera produced immunolabeling of retinal bipolar cells participated in the study [20].

References