Gene Review:
Fmo1 - flavin containing monooxygenase 1
Mus musculus
Synonyms:
Dimethylaniline oxidase 1, FMO 1, Fmo-1, Hepatic flavin-containing monooxygenase 1
- Molecular cloning, sequence, and expression of mouse flavin-containing monooxygenases 1 and 5 (FMO1 and FMO5). Cherrington, N.J., Falls, J.G., Rose, R.L., Clements, K.M., Philpot, R.M., Levi, P.E., Hodgson, E. J. Biochem. Mol. Toxicol. (1998)
- Evidence for the involvement of N-methylthiourea, a ring cleavage metabolite, in the hepatotoxicity of methimazole in glutathione-depleted mice: structure-toxicity and metabolic studies. Mizutani, T., Yoshida, K., Murakami, M., Shirai, M., Kawazoe, S. Chem. Res. Toxicol. (2000)
- Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters. Hernandez, D., Janmohamed, A., Chandan, P., Phillips, I.R., Shephard, E.A. Pharmacogenetics (2004)
- Cell-, tissue-, sex- and developmental stage-specific expression of mouse flavin-containing monooxygenases (Fmos). Janmohamed, A., Hernandez, D., Phillips, I.R., Shephard, E.A. Biochem. Pharmacol. (2004)
- Physiological factors affecting protein expression of flavin-containing monooxygenases 1, 3 and 5. Cherrington, N.J., Cao, Y., Cherrington, J.W., Rose, R.L., Hodgson, E. Xenobiotica (1998)
- Gender differences in hepatic expression of flavin-containing monooxygenase isoforms (FMO1, FMO3, and FMO5) in mice. Falls, J.G., Blake, B.L., Cao, Y., Levi, P.E., Hodgson, E. J. Biochem. Toxicol. (1995)
- Quantitative analysis of FMO gene mRNA levels in human tissues. Zhang, J., Cashman, J.R. Drug Metab. Dispos. (2006)
- Effects of N-methylmercaptoimidazole on the disposition of MPTP and its metabolites in mice. Chiba, K., Horii, H., Kubota, E., Ishizaki, T., Kato, Y. Eur. J. Pharmacol. (1990)
- Purification of the flavin-containing monooxygenase from mouse and pig liver microsomes. Sabourin, P.J., Smyser, B.P., Hodgson, E. Int. J. Biochem. (1984)
- Regulation of mouse liver flavin-containing monooxygenases 1 and 3 by sex steroids. Falls, J.G., Ryu, D.Y., Cao, Y., Levi, P.E., Hodgson, E. Arch. Biochem. Biophys. (1997)
- Flavin-containing monooxygenase isoform specificity for the N-oxidation of tamoxifen determined by product measurement and NADPH oxidation. Hodgson, E., Rose, R.L., Cao, Y., Dehal, S.S., Kupfer, D. J. Biochem. Mol. Toxicol. (2000)
- Molecular cloning of mouse liver flavin containing monooxygenase (FMO1) cDNA and characterization of the expression product: metabolism of the neurotoxin, 1,2,3,4-tetrahydroisoquinoline (TIQ). Itoh, K., Nakamura, K., Kimura, T., Itoh, S., Kamataki, T. The Journal of toxicological sciences. (1997)
- Characterization of hepatic microsomal metabolism as an in vivo detoxication pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Chiba, K., Kubota, E., Miyakawa, T., Kato, Y., Ishizaki, T. J. Pharmacol. Exp. Ther. (1988)
- Polyamine effects on cytochrome P-450- and flavin-containing monooxygenase-mediated oxidation of xenobiotics. Osimitz, T.G., Kulkarni, A.P. Drug Metab. Dispos. (1985)
- Spectrophotometric assay of the flavin-containing monooxygenase and changes in its activity in female mouse liver with nutritional and diurnal conditions. Dixit, A., Roche, T.E. Arch. Biochem. Biophys. (1984)
- Role of metabolism by flavin-containing monooxygenase in thioacetamide-induced immunosuppression. Lee, J.W., Shin, K.D., Lee, M., Kim, E.J., Han, S.S., Han, M.Y., Ha, H., Jeong, T.C., Koh, W.S. Toxicol. Lett. (2003)