Gene Review:
Ahr - aryl-hydrocarbon receptor
Mus musculus
Synonyms:
Ah, Ah receptor, AhR, Ahh, Ahre, ...
- Recruitment of dioxin receptor to active transcription sites. Elbi, C., Misteli, T., Hager, G.L. Mol. Biol. Cell (2002)
- How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress. Nebert, D.W., Duffy, J.J. Biochem. Pharmacol. (1997)
- Developmental expression of two members of a new class of transcription factors: II. Expression of aryl hydrocarbon receptor nuclear translocator in the C57BL/6N mouse embryo. Abbott, B.D., Probst, M.R. Dev. Dyn. (1995)
- Hypoxic inhibition of 3-methylcholanthrene-induced CYP1A1 expression is independent of HIF-1alpha. Allen, J.W., Johnson, R.S., Bhatia, S.N. Toxicol. Lett. (2005)
- Aryl hydrocarbon receptor null mice develop cardiac hypertrophy and increased hypoxia-inducible factor-1alpha in the absence of cardiac hypoxia. Thackaberry, E.A., Gabaldon, D.M., Walker, M.K., Smith, S.M. Cardiovasc. Toxicol. (2002)
- Aryl hydrocarbon receptor expression and activity in cerebellar granule neuroblasts: implications for development and dioxin neurotoxicity. Williamson, M.A., Gasiewicz, T.A., Opanashuk, L.A. Toxicol. Sci. (2005)
- Genetic differences in alcohol drinking preference between inbred strains of mice. He, X.X., Nebert, D.W., Vasiliou, V., Zhu, H., Shertzer, H.G. Pharmacogenetics (1997)
- Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. Matikainen, T., Perez, G.I., Jurisicova, A., Pru, J.K., Schlezinger, J.J., Ryu, H.Y., Laine, J., Sakai, T., Korsmeyer, S.J., Casper, R.F., Sherr, D.H., Tilly, J.L. Nat. Genet. (2001)
- Eggs in the balance. Matzuk, M.M. Nat. Genet. (2001)
- Aryl hydrocarbon receptor regulation of ceramide-induced apoptosis in murine hepatoma 1c1c7 cells. A function independent of aryl hydrocarbon receptor nuclear translocator. Reiners, J.J., Clift, R.E. J. Biol. Chem. (1999)
- Down-regulation of aryl hydrocarbon receptor-regulated genes by tumor necrosis factor-alpha and lipopolysaccharide in murine hepatoma Hepa 1c1c7 cells. Gharavi, N., El-Kadi, A.O. Journal of pharmaceutical sciences. (2005)
- The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes. Wormke, M., Stoner, M., Saville, B., Walker, K., Abdelrahim, M., Burghardt, R., Safe, S. Mol. Cell. Biol. (2003)
- The aryl hydrocarbon receptor, a basic helix-loop-helix transcription factor of the PAS gene family, is required for normal ovarian germ cell dynamics in the mouse. Robles, R., Morita, Y., Mann, K.K., Perez, G.I., Yang, S., Matikainen, T., Sherr, D.H., Tilly, J.L. Endocrinology (2000)
- Expression of genes in the TGF-beta signaling pathway is significantly deregulated in smooth muscle cells from aorta of aryl hydrocarbon receptor knockout mice. Guo, J., Sartor, M., Karyala, S., Medvedovic, M., Kann, S., Puga, A., Ryan, P., Tomlinson, C.R. Toxicol. Appl. Pharmacol. (2004)
- Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. Shimizu, Y., Nakatsuru, Y., Ichinose, M., Takahashi, Y., Kume, H., Mimura, J., Fujii-Kuriyama, Y., Ishikawa, T. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. Woods, S.L., Whitelaw, M.L. J. Biol. Chem. (2002)
- Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Ohtake, F., Takeyama, K., Matsumoto, T., Kitagawa, H., Yamamoto, Y., Nohara, K., Tohyama, C., Krust, A., Mimura, J., Chambon, P., Yanagisawa, J., Fujii-Kuriyama, Y., Kato, S. Nature (2003)
- The aryl hydrocarbon receptor predisposes hepatocytes to Fas-mediated apoptosis. Park, K.T., Mitchell, K.A., Huang, G., Elferink, C.J. Mol. Pharmacol. (2005)
- The aryl-hydrocarbon receptor, but not the aryl-hydrocarbon receptor nuclear translocator protein, is rapidly depleted in hepatic and nonhepatic culture cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Pollenz, R.S. Mol. Pharmacol. (1996)
- The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy. Pollenz, R.S., Sattler, C.A., Poland, A. Mol. Pharmacol. (1994)
- Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development. Walisser, J.A., Bunger, M.K., Glover, E., Bradfield, C.A. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor. Senft, A.P., Dalton, T.P., Nebert, D.W., Genter, M.B., Puga, A., Hutchinson, R.J., Kerzee, J.K., Uno, S., Shertzer, H.G. Free Radic. Biol. Med. (2002)
- Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB. Thatcher, T.H., Maggirwar, S.B., Baglole, C.J., Lakatos, H.F., Gasiewicz, T.A., Phipps, R.P., Sime, P.J. Am. J. Pathol. (2007)
- The aryl hydrocarbon receptor is required for optimal resistance to Listeria monocytogenes infection in mice. Shi, L.Z., Faith, N.G., Nakayama, Y., Suresh, M., Steinberg, H., Czuprynski, C.J. J. Immunol. (2007)
- Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor. Ryan, E.P., Holz, J.D., Mulcahey, M., Sheu, T.J., Gasiewicz, T.A., Puzas, J.E. J. Bone Miner. Res. (2007)
- Loss of dioxin-receptor expression accelerates wound healing in vivo by a mechanism involving TGFbeta. Carvajal-Gonzalez, J.M., Roman, A.C., Cerezo-Guisado, M.I., Rico-Leo, E.M., Martin-Partido, G., Fernandez-Salguero, P.M. J. Cell. Sci. (2009)
- Phorbol esters inhibit the dioxin receptor-mediated transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Okino, S.T., Pendurthi, U.R., Tukey, R.H. J. Biol. Chem. (1992)
- Influence of the Ah locus on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the hepatic epidermal growth factor receptor. Lin, F.H., Clark, G., Birnbaum, L.S., Lucier, G.W., Goldstein, J.A. Mol. Pharmacol. (1991)
- Relative sensitivities of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced Cyp1a-1 and Cyp1a-2 gene expression and immunotoxicity in female B6C3F1 mice. Narasimhan, T.R., Craig, A., Arellano, L., Harper, N., Howie, L., Menache, M., Birnbaum, L., Safe, S. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1994)
- Defining the role for XAP2 in stabilization of the dioxin receptor. Lees, M.J., Peet, D.J., Whitelaw, M.L. J. Biol. Chem. (2003)
- Identification of functional domains of the aryl hydrocarbon receptor. Fukunaga, B.N., Probst, M.R., Reisz-Porszasz, S., Hankinson, O. J. Biol. Chem. (1995)
- Liver portal fibrosis in dioxin receptor-null mice that overexpress the latent transforming growth factor-beta-binding protein-1. Corchero, J., Martín-Partido, G., Dallas, S.L., Fernández-Salguero, P.M. International journal of experimental pathology. (2004)
- In Utero Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Amphiregulin Gene Expression in the Developing Mouse Ureter. Choi, S.S.h., Miller, M.A., Harper, P.A. Toxicol. Sci. (2006)
- Tissue distribution and function of the Aryl hydrocarbon receptor repressor (AhRR) in C57BL/6 and Aryl hydrocarbon receptor deficient mice. Bernshausen, T., Jux, B., Esser, C., Abel, J., Fritsche, E. Arch. Toxicol. (2006)
- Comparison of expression of aldehyde dehydrogenase 3 and CYP1A1 in dominant and recessive aryl hydrocarbon hydroxylase-deficient mutant mouse hepatoma cells. Korkalainen, M.K., Törrönen, A.R., Kärenlampi, S.O. Chem. Biol. Interact. (1995)
- Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha. Tomita, S., Sinal, C.J., Yim, S.H., Gonzalez, F.J. Mol. Endocrinol. (2000)
- Structure and expression of the Ah receptor repressor gene. Baba, T., Mimura, J., Gradin, K., Kuroiwa, A., Watanabe, T., Matsuda, Y., Inazawa, J., Sogawa, K., Fujii-Kuriyama, Y. J. Biol. Chem. (2001)
- Determination of aryl hydrocarbon receptor nuclear translocator protein concentration and subcellular localization in hepatic and nonhepatic cell culture lines: development of quantitative Western blotting protocols for calculation of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein in total cell lysates. Holmes, J.L., Pollenz, R.S. Mol. Pharmacol. (1997)