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Gene Review

Gjb5  -  gap junction protein, beta 5

Mus musculus

Synonyms: Cnx31.1, Connexin-31.1, Cx31.1, Cxn-31.1, Gap junction beta-5 protein, ...
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High impact information on Gjb5


Biological context of Gjb5

  • Here, we present data on expression of the gap-junctional protein connexins (Cx) 26, Cx31.1, and Cx43 in a comprehensive panel of keratinocyte cell lines representing different stages of mouse skin carcinogenesis and the effect of different conditions of propagation on Cx phenotype [4].

Anatomical context of Gjb5


Associations of Gjb5 with chemical compounds

  • The peaks of Cx26 and Cx43 expression and Cx31.1 inhibition appeared 12 h after TPA application and 24 h after OA and chrysarobin application [5].

Analytical, diagnostic and therapeutic context of Gjb5


  1. Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin. Hennemann, H., Dahl, E., White, J.B., Schwarz, H.J., Lalley, P.A., Chang, S., Nicholson, B.J., Willecke, K. J. Biol. Chem. (1992) [Pubmed]
  2. Connexin31-deficient trophoblast stem cells: a model to analyze the role of gap junction communication in mouse placental development. Kibschull, M., Nassiry, M., Dunk, C., Gellhaus, A., Quinn, J.A., Rossant, J., Lye, S.J., Winterhager, E. Dev. Biol. (2004) [Pubmed]
  3. Multiple members of the connexin gene family participate in preimplantation development of the mouse. Davies, T.C., Barr, K.J., Jones, D.H., Zhu, D., Kidder, G.M. Dev. Genet. (1996) [Pubmed]
  4. Connexin expression in epidermal cell lines from SENCAR mouse skin tumors. Budunova, I.V., Carbajal, S., Viaje, A., Slaga, T.J. Mol. Carcinog. (1996) [Pubmed]
  5. Effect of diverse tumor promoters on the expression of gap-junctional proteins connexin (Cx)26, Cx31.1, and Cx43 in SENCAR mouse epidermis. Budunova, I.V., Carbajal, S., Slaga, T.J. Mol. Carcinog. (1996) [Pubmed]
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