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Gene Review

SPC24  -  SPC24, NDC80 kinetochore complex component

Homo sapiens

Synonyms: FLJ90806, Kinetochore protein Spc24, SPBC24, hSpc24
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High impact information on SPC24

  • Formation of the complete KMN network, which additionally requires the Mis12 complex and the Spc24/Spc25 subunits of the Ndc80 complex, synergistically enhances microtubule-binding activity [1].
  • Two tight Hec1-Nuf2 and Spc24-Spc25 subcomplexes, each stabilized by a parallel heterodimeric coiled coil, maintain this organization [2].
  • The Ndc80 complex, comprised of Ndc80 (Hec1), Nuf2, Spc24, and Spc25, is essential for metaphase chromosome alignment and anaphase chromosome segregation [3].
  • In addition, we show that Spc24 and Spc25 are required for chromosomal movement to the spindle poles in anaphase [4].
  • Although the sequences have greatly diverged, we have concluded that these are the functional homologs of the yeast Spc24 and Spc25 proteins based on limited sequence similarity, common coiled-coil domains, kinetochore localization, similar phenotypes, and copurification with xNdc80 and xNuf2 [4].

Biological context of SPC24

  • Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain [5].
  • Using both RNAi and antibody injection experiments, we have extended previous characterization of the complex and found that Spc24 and Spc25 are required not only to establish, but also to maintain kinetochore-microtubule attachments and metaphase alignment [4].

Analytical, diagnostic and therapeutic context of SPC24

  • We report the atomic structures of the Spc24/Spc25 globular domain, determined both by X-ray crystallography at 1.9 A resolution and by NMR [5].


  1. The Conserved KMN Network Constitutes the Core Microtubule-Binding Site of the Kinetochore. Cheeseman, I.M., Chappie, J.S., Wilson-Kubalek, E.M., Desai, A. Cell (2006) [Pubmed]
  2. Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore. Ciferri, C., De Luca, J., Monzani, S., Ferrari, K.J., Ristic, D., Wyman, C., Stark, H., Kilmartin, J., Salmon, E.D., Musacchio, A. J. Biol. Chem. (2005) [Pubmed]
  3. Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites. DeLuca, J.G., Dong, Y., Hergert, P., Strauss, J., Hickey, J.M., Salmon, E.D., McEwen, B.F. Mol. Biol. Cell (2005) [Pubmed]
  4. The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. McCleland, M.L., Kallio, M.J., Barrett-Wilt, G.A., Kestner, C.A., Shabanowitz, J., Hunt, D.F., Gorbsky, G.J., Stukenberg, P.T. Curr. Biol. (2004) [Pubmed]
  5. Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. Wei, R.R., Schnell, J.R., Larsen, N.A., Sorger, P.K., Chou, J.J., Harrison, S.C. Structure (2006) [Pubmed]
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