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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Gstt2  -  glutathione S-transferase, theta 2

Mus musculus

Synonyms: AI266894, GST class-theta-2, Glutathione S-transferase theta-2, Yrs, mGSTT2
 
 
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High impact information on Gstt2

  • The gene encoding mGSTT3 is clustered with the mGSTT1 and mGSTT2 genes on chromosome 10 and has an exon/intron structure that is similar to that of the other Theta class genes. mGSTT3 is expressed strongly in the liver and to a decreasing extent in the kidney and testis [1].
  • Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1 [2].
  • Southern blot analysis of mouse genomic DNA suggests that there is only one copy of mGSTT2 in the mouse genome [2].
  • The gene, mGSTT2, spans approximately 3.1 kb and is composed of five exons interrupted by four introns [2].
  • The cDNA derived from mGSTT2 was isolated from a mouse liver cDNA library and has an open reading frame of 732 bp encoding a peptide of 244 amino acids with a calculated molecular weight of 26,676 Da [2].
 

Biological context of Gstt2

  • The first 28 N-terminal amino acid sequence of the GST was completely identical to that of rat subfamily 2 GST Yrs-Yrs of the class theta [3].

References

  1. Identification and characterization of GSTT3, a third murine Theta class glutathione transferase. Coggan, M., Flanagan, J.U., Parker, M.W., Vichai, V., Pearson, W.R., Board, P.G. Biochem. J. (2002) [Pubmed]
  2. Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1. Whittington, A.T., Webb, G.C., Baker, R.T., Board, P.G. Genomics (1996) [Pubmed]
  3. A subfamily 2 homo-dimeric glutathione S-transferase mYrs-mYrs of class theta in mouse liver cytosol. Hiratsuka, A., Kanazawa, M., Nishiyama, T., Okuda, H., Ogura, K., Watabe, T. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
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