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Gene Review

E  -  protein E

SARS coronavirus

 
 
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Disease relevance of E

 

High impact information on E

  • Expression studies have shown that the coronavirus small envelope protein E and the much more abundant membrane glycoprotein M are both necessary and sufficient for the assembly of virus-like particles in cells [3].
  • The model we report for this pentameric alpha-helical bundle may explain some of the permabilizing properties of protein E, and should be the basis of mutagenesis efforts in future functional studies [4].
  • METHODS: Vero E6 cells were transfected with plasmid constructs containing exons of the SARS-CoV structural protein E, M or N genes or their exons in frame with the reporter protein EGFP [5].
  • The models arising from the molecular dynamics simulations were tested for evolutionary conservation using 13 coronavirus protein E homologous sequences [2].
  • Small envelope protein E of SARS: cloning, expression, purification, CD determination, and bioinformatics analysis [6].

References

  1. The small envelope protein E is not essential for murine coronavirus replication. Kuo, L., Masters, P.S. J. Virol. (2003) [Pubmed]
  2. The transmembrane oligomers of coronavirus protein E. Torres, J., Wang, J., Parthasarathy, K., Liu, D.X. Biophys. J. (2005) [Pubmed]
  3. Analysis of constructed E gene mutants of mouse hepatitis virus confirms a pivotal role for E protein in coronavirus assembly. Fischer, F., Stegen, C.F., Masters, P.S., Samsonoff, W.A. J. Virol. (1998) [Pubmed]
  4. Model of a putative pore: the pentameric alpha-helical bundle of SARS coronavirus E protein in lipid bilayers. Torres, J., Parthasarathy, K., Lin, X., Saravanan, R., Kukol, A., Liu, D.X. Biophys. J. (2006) [Pubmed]
  5. Antisense downregulation of SARS-CoV gene expression in Vero E6 cells. Shi, Y., Luo, H., Jia, J., Xiong, J., Yang, D., Huang, B., Jin, Y. The journal of gene medicine. (2005) [Pubmed]
  6. Small envelope protein E of SARS: cloning, expression, purification, CD determination, and bioinformatics analysis. Shen, X., Xue, J.H., Yu, C.Y., Luo, H.B., Qin, L., Yu, X.J., Chen, J., Chen, L.L., Xiong, B., Yue, L.D., Cai, J.H., Shen, J.H., Luo, X.M., Chen, K.X., Shi, T.L., Li, Y.X., Hu, G.X., Jiang, H.L. Acta Pharmacol. Sin. (2003) [Pubmed]
 
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