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MeSH Review

Severe Acute Respiratory Syndrome

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Disease relevance of Severe Acute Respiratory Syndrome


High impact information on Severe Acute Respiratory Syndrome


Chemical compound and disease context of Severe Acute Respiratory Syndrome


Biological context of Severe Acute Respiratory Syndrome


Anatomical context of Severe Acute Respiratory Syndrome


Gene context of Severe Acute Respiratory Syndrome


Analytical, diagnostic and therapeutic context of Severe Acute Respiratory Syndrome


  1. ACE2: from vasopeptidase to SARS virus receptor. Turner, A.J., Hiscox, J.A., Hooper, N.M. Trends Pharmacol. Sci. (2004) [Pubmed]
  2. Clinical trials and novel pathogens: lessons learned from SARS. Muller, M.P., McGeer, A., Straus, S.E., Hawryluck, L., Gold, W.L. Emerging Infect. Dis. (2004) [Pubmed]
  3. Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2. Moore, M.J., Dorfman, T., Li, W., Wong, S.K., Li, Y., Kuhn, J.H., Coderre, J., Vasilieva, N., Han, Z., Greenough, T.C., Farzan, M., Choe, H. J. Virol. (2004) [Pubmed]
  4. SARS: clinical presentation, transmission, pathogenesis and treatment options. Chan, P.K., Tang, J.W., Hui, D.S. Clin. Sci. (2006) [Pubmed]
  5. Nosocomial acquisition of methicillin-resistant Staphylococcus aureus during an outbreak of severe acute respiratory syndrome. Poutanen, S.M., Vearncombe, M., McGeer, A.J., Gardam, M., Large, G., Simor, A.E. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (2005) [Pubmed]
  6. Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme. Ratia, K., Saikatendu, K.S., Santarsiero, B.D., Barretto, N., Baker, S.C., Stevens, R.C., Mesecar, A.D. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  7. Severe acute respiratory syndrome (SARS) S protein production in plants: development of recombinant vaccine. Pogrebnyak, N., Golovkin, M., Andrianov, V., Spitsin, S., Smirnov, Y., Egolf, R., Koprowski, H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  8. Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. Simmons, G., Gosalia, D.N., Rennekamp, A.J., Reeves, J.D., Diamond, S.L., Bates, P. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  9. CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. Jeffers, S.A., Tusell, S.M., Gillim-Ross, L., Hemmila, E.M., Achenbach, J.E., Babcock, G.J., Thomas, W.D., Thackray, L.B., Young, M.D., Mason, R.J., Ambrosino, D.M., Wentworth, D.E., Demartini, J.C., Holmes, K.V. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  10. Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association. Sui, J., Li, W., Murakami, A., Tamin, A., Matthews, L.J., Wong, S.K., Moore, M.J., Tallarico, A.S., Olurinde, M., Choe, H., Anderson, L.J., Bellini, W.J., Farzan, M., Marasco, W.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  11. Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). Lambert, D.W., Yarski, M., Warner, F.J., Thornhill, P., Parkin, E.T., Smith, A.I., Hooper, N.M., Turner, A.J. J. Biol. Chem. (2005) [Pubmed]
  12. A novel sorting signal for intracellular localization is present in the S protein of a porcine coronavirus but absent from severe acute respiratory syndrome-associated coronavirus. Schwegmann-Wessels, C., Al-Falah, M., Escors, D., Wang, Z., Zimmer, G., Deng, H., Enjuanes, L., Naim, H.Y., Herrler, G. J. Biol. Chem. (2004) [Pubmed]
  13. Modulation of the immune response to the severe acute respiratory syndrome spike glycoprotein by gene-based and inactivated virus immunization. Kong, W.P., Xu, L., Stadler, K., Ulmer, J.B., Abrignani, S., Rappuoli, R., Nabel, G.J. J. Virol. (2005) [Pubmed]
  14. Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease. Wu, C.Y., King, K.Y., Kuo, C.J., Fang, J.M., Wu, Y.T., Ho, M.Y., Liao, C.L., Shie, J.J., Liang, P.H., Wong, C.H. Chem. Biol. (2006) [Pubmed]
  15. Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus. Akerström, S., Mousavi-Jazi, M., Klingström, J., Leijon, M., Lundkvist, A., Mirazimi, A. J. Virol. (2005) [Pubmed]
  16. Exploring the pathogenesis of severe acute respiratory syndrome (SARS): the tissue distribution of the coronavirus (SARS-CoV) and its putative receptor, angiotensin-converting enzyme 2 (ACE2). To, K.F., Lo, A.W. J. Pathol. (2004) [Pubmed]
  17. Antibody response of patients with severe acute respiratory syndrome (SARS) targets the viral nucleocapsid. Leung, D.T., Tam, F.C., Ma, C.H., Chan, P.K., Cheung, J.L., Niu, H., Tam, J.S., Lim, P.L. J. Infect. Dis. (2004) [Pubmed]
  18. Severe acute respiratory syndrome coronavirus membrane protein interacts with nucleocapsid protein mostly through their carboxyl termini by electrostatic attraction. Luo, H., Wu, D., Shen, C., Chen, K., Shen, X., Jiang, H. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
  19. Pro/con clinical debate: isolation precautions for all intensive care unit patients with methicillin-resistant Staphylococcus aureus colonization are essential. Farr, B.M., Bellingan, G. Critical care (London, England) (2004) [Pubmed]
  20. Altered p38 mitogen-activated protein kinase expression in different leukocytes with increment of immunosuppressive mediators in patients with severe acute respiratory syndrome. Lee, C.H., Chen, R.F., Liu, J.W., Yeh, W.T., Chang, J.C., Liu, P.M., Eng, H.L., Lin, M.C., Yang, K.D. J. Immunol. (2004) [Pubmed]
  21. B-cell responses in patients who have recovered from severe acute respiratory syndrome target a dominant site in the S2 domain of the surface spike glycoprotein. Zhong, X., Yang, H., Guo, Z.F., Sin, W.Y., Chen, W., Xu, J., Fu, L., Wu, J., Mak, C.K., Cheng, C.S., Yang, Y., Cao, S., Wong, T.Y., Lai, S.T., Xie, Y., Guo, Z. J. Virol. (2005) [Pubmed]
  22. Intracellular localization of the severe acute respiratory syndrome coronavirus nucleocapsid protein: absence of nucleolar accumulation during infection and after expression as a recombinant protein in vero cells. Rowland, R.R., Chauhan, V., Fang, Y., Pekosz, A., Kerrigan, M., Burton, M.D. J. Virol. (2005) [Pubmed]
  23. Detection and monitoring of SARS coronavirus in the plasma and peripheral blood lymphocytes of patients with severe acute respiratory syndrome. Wang, H., Mao, Y., Ju, L., Zhang, J., Liu, Z., Zhou, X., Li, Q., Wang, Y., Kim, S., Zhang, L. Clin. Chem. (2004) [Pubmed]
  24. Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome. Zhang, Z., Xu, D., Li, Y., Jin, L., Shi, M., Wang, M., Zhou, X., Wu, H., Gao, G.F., Wang, F.S. Clin. Immunol. (2005) [Pubmed]
  25. Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome. Tang, N.L., Chan, P.K., Wong, C.K., To, K.F., Wu, A.K., Sung, Y.M., Hui, D.S., Sung, J.J., Lam, C.W. Clin. Chem. (2005) [Pubmed]
  26. Elevated plasma tissue-type plasminogen activator (t-PA) and soluble thrombomodulin in patients suffering from severe acute respiratory syndrome (SARS) as a possible index for prognosis and treatment strategy. Liu, Z.H., Wei, R., Wu, Y.P., Lisman, T., Wang, Z.X., Han, J.J., Ren, D.L., Chen, B., Xia, Z.L., Chen, B., Zhu, Z., Zhang, Y., Cui, X., Hu, H.T., de Groot, P.G., Xu, W.B. Biomed. Environ. Sci. (2005) [Pubmed]
  27. Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome. Jiang, Y., Xu, J., Zhou, C., Wu, Z., Zhong, S., Liu, J., Luo, W., Chen, T., Qin, Q., Deng, P. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  28. Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection. Ip, W.K., Chan, K.H., Law, H.K., Tso, G.H., Kong, E.K., Wong, W.H., To, Y.F., Yung, R.W., Chow, E.Y., Au, K.L., Chan, E.Y., Lim, W., Jensenius, J.C., Turner, M.W., Peiris, J.S., Lau, Y.L. J. Infect. Dis. (2005) [Pubmed]
  29. Function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus. Chen, Z., Mi, L., Xu, J., Yu, J., Wang, X., Jiang, J., Xing, J., Shang, P., Qian, A., Li, Y., Shaw, P.X., Wang, J., Duan, S., Ding, J., Fan, C., Zhang, Y., Yang, Y., Yu, X., Feng, Q., Li, B., Yao, X., Zhang, Z., Li, L., Xue, X., Zhu, P. J. Infect. Dis. (2005) [Pubmed]
  30. Protein chip array profiling analysis in patients with severe acute respiratory syndrome identified serum amyloid a protein as a biomarker potentially useful in monitoring the extent of pneumonia. Yip, T.T., Chan, J.W., Cho, W.C., Yip, T.T., Wang, Z., Kwan, T.L., Law, S.C., Tsang, D.N., Chan, J.K., Lee, K.C., Cheng, W.W., Ma, V.W., Yip, C., Lim, C.K., Ngan, R.K., Au, J.S., Chan, A., Lim, W.W. Clin. Chem. (2005) [Pubmed]
  31. Diagnosis of severe acute respiratory syndrome (SARS) by detection of SARS coronavirus nucleocapsid antibodies in an antigen-capturing enzyme-linked immunosorbent assay. Shi, Y., Yi, Y., Li, P., Kuang, T., Li, L., Dong, M., Ma, Q., Cao, C. J. Clin. Microbiol. (2003) [Pubmed]
  32. Sensitive and specific monoclonal antibody-based capture enzyme immunoassay for detection of nucleocapsid antigen in sera from patients with severe acute respiratory syndrome. Che, X.Y., Qiu, L.W., Pan, Y.X., Wen, K., Hao, W., Zhang, L.Y., Wang, Y.D., Liao, Z.Y., Hua, X., Cheng, V.C., Yuen, K.Y. J. Clin. Microbiol. (2004) [Pubmed]
  33. A serological survey on neutralizing antibody titer of SARS convalescent sera. Zhang, J.S., Chen, J.T., Liu, Y.X., Zhang, Z.S., Gao, H., Liu, Y., Wang, X., Ning, Y., Liu, Y.F., Gao, Q., Xu, J.G., Qin, C., Dong, X.P., Yin, W.D. J. Med. Virol. (2005) [Pubmed]
  34. Serological responses in patients with severe acute respiratory syndrome coronavirus infection and cross-reactivity with human coronaviruses 229E, OC43, and NL63. Chan, K.H., Cheng, V.C., Woo, P.C., Lau, S.K., Poon, L.L., Guan, Y., Seto, W.H., Yuen, K.Y., Peiris, J.S. Clin. Diagn. Lab. Immunol. (2005) [Pubmed]
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