The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SRFBP1  -  serum response factor binding protein 1

Homo sapiens

Synonyms: BUD22, FLJ25286, P49, Rlb1, SRF-dependent transcription regulation-associated protein, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SRFBP1


Psychiatry related information on SRFBP1

  • Adult thalamocortical terminals visualized by anterograde tract-tracing display significantly larger cross-section areas than terminals at postnatal day (P) 35, P40, and P49 critical period ages [2].

High impact information on SRFBP1

  • Ectopically expressed P49 blocked apoptosis in cultured cells from a phylogenetically distinct organism, Drosophila melanogaster [3].
  • In separate experiments, behavioural testing of the forelimb was carried out between P35 and P49 [4].
  • In P40, P49, and adult brains, 23%, 17%, and 9%, respectively, of all thalamocortical synapses contact GABAergic interneurons, suggesting that thalamic input is more strongly involved in driving inhibitory circuits in young ages [2].
  • The three dominant T cell epitopes (P49, P70 and P155) were deleted individually or in combination by site directed mutagenesis, and the recombinant human G1 (rhG1) domain (wild type and mutated) proteins were used for immunization [5].
  • A 13-amino acid peptide (P49) corresponding to the putative DS binding site region of the murine anion exchange protein was synthesized, and polyclonal antibodies were generated against it and then purified over a P49 affinity column [6].

Analytical, diagnostic and therapeutic context of SRFBP1

  • These findings suggest that recombinant P49 is a potentially valuable antigen both for vaccine development and immunodiagnosis [7].


  1. Characterization of the apoptosis suppressor protein P49 from the Spodoptera littoralis nucleopolyhedrovirus. Pei, Z., Reske, G., Huang, Q., Hammock, B.D., Qi, Y., Chejanovsky, N. J. Biol. Chem. (2002) [Pubmed]
  2. Quantitative morphology and postsynaptic targets of thalamocortical axons in critical period and adult ferret visual cortex. Erisir, A., Dreusicke, M. J. Comp. Neurol. (2005) [Pubmed]
  3. Baculovirus apoptotic suppressor P49 is a substrate inhibitor of initiator caspases resistant to P35 in vivo. Zoog, S.J., Schiller, J.J., Wetter, J.A., Chejanovsky, N., Friesen, P.D. EMBO J. (2002) [Pubmed]
  4. The effects of botulinum neurotoxin A induced muscle paresis during a critical period upon muscle and spinal cord development in the rat. Clowry, G.J., Walker, L., Davies, P. Exp. Neurol. (2006) [Pubmed]
  5. Molecular manipulation with the arthritogenic epitopes of the G1 domain of human cartilage proteoglycan aggrecan. Murad, Y.M., Szabó, Z., Ludányi, K., Glant, T.T. Clin. Exp. Immunol. (2005) [Pubmed]
  6. Identification of a membrane protein from T84 cells using antibodies made against a DIDS-binding peptide. Sorscher, E.J., Fuller, C.M., Bridges, R.J., Tousson, A., Marchase, R.B., Brinkley, B.R., Frizzell, R.A., Benos, D.J. Am. J. Physiol. (1992) [Pubmed]
  7. Cloning and expression of complementary DNA encoding an antigen of Trichinella spiralis. Su, X.Z., Prestwood, A.K., McGraw, R.A. Mol. Biochem. Parasitol. (1991) [Pubmed]
WikiGenes - Universities