Disease relevance of SRFBP1

• The high structural homology between P49 and P35 suggests that these molecules bear a scaffold common to baculovirus "apoptotic suppressor" proteins [1].
• Characterization of the apoptosis suppressor protein P49 from the Spodoptera littoralis nucleopolyhedrovirus [1].

Psychiatry related information on SRFBP1

• Adult thalamocortical terminals visualized by anterograde tract-tracing display significantly larger cross-section areas than terminals at postnatal day (P) 35, P40, and P49 critical period ages [2].

High impact information on SRFBP1

• Ectopically expressed P49 blocked apoptosis in cultured cells from a phylogenetically distinct organism, Drosophila melanogaster [3].
• In separate experiments, behavioural testing of the forelimb was carried out between P35 and P49 [4].
• In P40, P49, and adult brains, 23%, 17%, and 9%, respectively, of all thalamocortical synapses contact GABAergic interneurons, suggesting that thalamic input is more strongly involved in driving inhibitory circuits in young ages [2].
• The three dominant T cell epitopes (P49, P70 and P155) were deleted individually or in combination by site directed mutagenesis, and the recombinant human G1 (rhG1) domain (wild type and mutated) proteins were used for immunization [5].
• A 13-amino acid peptide (P49) corresponding to the putative DS binding site region of the murine anion exchange protein was synthesized, and polyclonal antibodies were generated against it and then purified over a P49 affinity column [6].

Analytical, diagnostic and therapeutic context of SRFBP1

• These findings suggest that recombinant P49 is a potentially valuable antigen both for vaccine development and immunodiagnosis [7].

References