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CNKSR3  -  CNKSR family member 3

Homo sapiens

Synonyms: CNK homolog protein 3, CNK3, Connector enhancer of KSR 3, Connector enhancer of kinase suppressor of ras 3, FLJ31349, ...
 
 
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Disease relevance of CNKSR3

  • Contrary to SupT1 cells, which encode several mutations on the p53 DNA binding domain, death of HIV-1-induced syncytia was reduced in cocultures of HeLa P4-R5 MAGI with persistently infected HIV-1 cells [1].
  • An MTT assay using CD4-, CXCR4-, and CCR5-transduced human glioma NP-2 cells (NCK45 cells) was established and then compared with the representative assays including multinuclear activation of a galactosidase indicator assay (MAGI assay) [2].
 

High impact information on CNKSR3

  • Junctional adhesion molecule 4 (JAM4) is a cell adhesion molecule that interacts with a tight junction protein, membrane-associated guanylate kinase inverted 1 (MAGI-1) [3].
  • (13)C, (15)N and (1)H Resonance Assignment of the PDZ1 domain of MAGI-1 using QUASI [4].
  • Moreover, in HaCaT cells overexpressing the MAGI-1 Asp(761)Ala mutant the disruption of cell-cell contacts was delayed during apoptosis, whereas other caspase-dependent processes such as nuclear condensation were not affected, suggesting that cell detachment is parallel to them [5].
 

Biological context of CNKSR3

  • Thus, MAGI-1 cleavage appears to be an important step in the disassembly of cell-cell contacts during apoptosis [5].

References

  1. Inhibition of HIV-1 replication by RNA interference of p53 expression. Pauls, E., Senserrich, J., Clotet, B., Esté, J.A. J. Leukoc. Biol. (2006) [Pubmed]
  2. A novel colorimetric assay for CXCR4 and CCR5 tropic human immunodeficiency viruses. Kajiwara, K., Kodama, E., Matsuoka, M. Antivir. Chem. Chemother. (2006) [Pubmed]
  3. Ligand-of-Numb protein X is an endocytic scaffold for junctional adhesion molecule 4. Kansaku, A., Hirabayashi, S., Mori, H., Fujiwara, N., Kawata, A., Ikeda, M., Rokukawa, C., Kurihara, H., Hata, Y. Oncogene (2006) [Pubmed]
  4. (13)C, (15)N and (1)H Resonance Assignment of the PDZ1 domain of MAGI-1 using QUASI. Charbonnier, S., Coutouly, M.A., Kieffer, B., Trav??, G., Atkinson, R.A. J. Biomol. NMR (2006) [Pubmed]
  5. Cleavage of MAGI-1, a tight junction PDZ protein, by caspases is an important step for cell-cell detachment in apoptosis. Gregorc, U., Ivanova, S., Thomas, M., Guccione, E., Glaunsinger, B., Javier, R., Turk, V., Banks, L., Turk, B. Apoptosis (2007) [Pubmed]
 
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