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Disease relevance of Decidua


High impact information on Decidua

  • In addition, Hand1 is expressed in extraembryonic membranes, whereas Hand2 is expressed in the deciduum [6].
  • During early pregnancy, in response to the implanting embryo, the surrounding uterine stroma undergoes a dramatic transformation into a specialized tissue known as the decidua [7].
  • 1 alpha, 25-Dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 in vitro synthesis by human decidua and placenta [8].
  • Here we show that the receptor for the cytokine interleukin-11 (IL-11Ralpha) is required specifically for normal establishment of the decidua [9].
  • Implantation sites in mice lacking uNK cells (alymphoid recombinase activating gene [RAG]-2(-/)- common cytokine receptor chain gamma [gamma(c)](-/)-) or IFN-gamma signaling (IFN-gamma(-/)- or IFN-gammaRalpha(-/)-) fail to initiate normal pregnancy-induced modification of decidual arteries and display hypocellularity or necrosis of decidua [10].

Chemical compound and disease context of Decidua


Biological context of Decidua


Anatomical context of Decidua

  • 5. However, the E4.5 beta 1-null embryos in situ had collapsed blastocoeles, and whereas the trophoblast penetrated the uterine epithelium, extensive invasion of the decidua was not observed [21].
  • (ii) The level of c-fos transcripts is greater than or equal to 15-fold higher in the separated outer portion of the midgestation placenta (primarily undifferentiated fetus-derived cytotrophoblast maternal decidua) relative to the inner moiety (predominantly differentiated syncytiotrophoblast) [22].
  • MHC class II-positive antigen-presenting cells in the decidua [23].
  • During the process of decidual neovascularization, uPA expression was detected in endothelial cell cords traversing the maternal decidua in the direction of the newly implanted embryo. uPA mRNA was not detected in endothelial cells upon completion of neovascularization, suggesting that uPA expression is a part of the angiogenic response [16].
  • Here we show that IL-6 mRNA is produced in vivo in two self-limiting physiologic angiogenic processes: (i) the formation of the vascular system accompanying development of ovarian follicles and (ii) the formation of a capillary network in the maternal decidua following embryonic implantation [24].

Associations of Decidua with chemical compounds

  • Using in situ hybridization, we show that VEGF is expressed in 10 different steroidogenic and/or steroid-responsive cell types (theca, cumulus, granulosa, lutein, oviductal epithelium, endometrial stroma, decidua, giant trophoblast cells, adrenal cortex, and Leydig cells) [25].
  • VEGF was predominantly produced in tissues that acquire new capillary networks (theca layers, lutein cells, endometrial stroma, and the maternal decidua, respectively) [25].
  • The constitutively high levels of MT mRNA in decidua were only slightly elevated following injection of cadmium (Cd) and/or zinc (Zn), whereas in placentae they increased several-fold [17].
  • The progesterone-induced signaling molecules that participate in the formation and function of decidua remain poorly understood [26].
  • The expression of alpha(1)-acid glycoprotein mRNA during rat development. High levels of expression in the decidua [27].

Gene context of Decidua

  • The placenta and the uterine decidua most abundantly expressed this cadherin [28].
  • The HLA-G gene is primarily expressed in placental cells that invade the maternal decidua during pregnancy [29].
  • In this study we analyze the chemokine receptor repertoire on various NK populations derived from the peripheral blood and decidua [30].
  • In vivo, at day 6.5 of mouse development, activin beta A RNA is detectable in the decidua and bone morphogenetic protein 4 RNA is detectable in the egg cylinder [31].
  • We show that CXCR4 and CXCR3 receptors are preferentially expressed on CD16- NK subsets derived either from the peripheral blood or the decidua and that these receptors are involved in migration of all NK subsets to their ligands [30].

Analytical, diagnostic and therapeutic context of Decidua


  1. Cachectin/tumor necrosis factor-alpha formation in human decidua. Potential role of cytokines in infection-induced preterm labor. Casey, M.L., Cox, S.M., Beutler, B., Milewich, L., MacDonald, P.C. J. Clin. Invest. (1989) [Pubmed]
  2. Indoleamine 2,3-dioxygenase is regulated by IFN-gamma in the mouse placenta during Listeria monocytogenes infection. Mackler, A.M., Barber, E.M., Takikawa, O., Pollard, J.W. J. Immunol. (2003) [Pubmed]
  3. Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA. Julkunen, M., Koistinen, R., Aalto-Setälä, K., Seppälä, M., Jänne, O.A., Kontula, K. FEBS Lett. (1988) [Pubmed]
  4. Increased contents of phospholipids, cholesterol, and lipid peroxides in decidua basalis in women with preeclampsia. Staff, A.C., Ranheim, T., Khoury, J., Henriksen, T. Am. J. Obstet. Gynecol. (1999) [Pubmed]
  5. Differing concentrations of human chorionic gonadotropin and prolactin in the cyst fluid of hydatidiform mole and in amniotic fluid. Yuen, B.H. Am. J. Obstet. Gynecol. (1987) [Pubmed]
  6. Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Firulli, A.B., McFadden, D.G., Lin, Q., Srivastava, D., Olson, E.N. Nat. Genet. (1998) [Pubmed]
  7. Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation. Robb, L., Li, R., Hartley, L., Nandurkar, H.H., Koentgen, F., Begley, C.G. Nat. Med. (1998) [Pubmed]
  8. 1 alpha, 25-Dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 in vitro synthesis by human decidua and placenta. Weisman, Y., Harell, A., Edelstein, S., David, M., Spirer, Z., Golander, A. Nature (1979) [Pubmed]
  9. Maternal IL-11Ralpha function is required for normal decidua and fetoplacental development in mice. Bilinski, P., Roopenian, D., Gossler, A. Genes Dev. (1998) [Pubmed]
  10. Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy. Ashkar, A.A., Di Santo, J.P., Croy, B.A. J. Exp. Med. (2000) [Pubmed]
  11. A murine model of preterm labor: inflammatory mediators regulate the production of prostaglandin E2 and interleukin-6 by murine decidua. Dudley, D.J., Chen, C.L., Branch, D.W., Hammond, E., Mitchell, M.D. Biol. Reprod. (1993) [Pubmed]
  12. The fgl2 prothrombinase/fibroleukin gene is required for lipopolysaccharide-triggered abortions and for normal mouse reproduction. Clark, D.A., Foerster, K., Fung, L., He, W., Lee, L., Mendicino, M., Markert, U.R., Gorczynski, R.M., Marsden, P.A., Levy, G.A. Mol. Hum. Reprod. (2004) [Pubmed]
  13. Glutathione and glutathione-related enzymes in decidua and placenta of controls and women with pre-eclampsia. Knapen, M.F., Peters, W.H., Mulder, T.P., Merkus, H.M., Jansen, J.B., Steegers, E.A. Placenta (1999) [Pubmed]
  14. Secretion of the vasoactive peptides, endothelin, and parathyroid hormone-related peptide, by decidual explants from pregnancies complicated by intrauterine growth restriction. Heffner, L.J., Kumari, M., Benoit, L.A. J. Soc. Gynecol. Investig. (1999) [Pubmed]
  15. Biochemistry and physiology of preterm labour and delivery. López Bernal, A., Watson, S.P., Phaneuf, S., Europe-Finner, G.N. Baillière's clinical obstetrics and gynaecology. (1993) [Pubmed]
  16. In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis. Bacharach, E., Itin, A., Keshet, E. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  17. Cell-specific metallothionein gene expression in mouse decidua and placentae. De, S.K., McMaster, M.T., Dey, S.K., Andrews, G.K. Development (1989) [Pubmed]
  18. Analysis of HLA-G mRNA in human placental and extraplacental membrane cells by in situ hybridization. Yelavarthi, K.K., Fishback, J.L., Hunt, J.S. J. Immunol. (1991) [Pubmed]
  19. Synthesis of T helper 2-type cytokines at the maternal-fetal interface. Lin, H., Mosmann, T.R., Guilbert, L., Tuntipopipat, S., Wegmann, T.G. J. Immunol. (1993) [Pubmed]
  20. Active suppression of host-vs-graft reaction in pregnant mice. VI. Soluble suppressor activity obtained from decidua of allopregnant mice blocks the response to IL 2. Clark, D.A., Chaput, A., Walker, C., Rosenthal, K.L. J. Immunol. (1985) [Pubmed]
  21. Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality. Stephens, L.E., Sutherland, A.E., Klimanskaya, I.V., Andrieux, A., Meneses, J., Pedersen, R.A., Damsky, C.H. Genes Dev. (1995) [Pubmed]
  22. Expression of c-onc genes: c-fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion. Müller, R., Verma, I.M., Adamson, E.D. EMBO J. (1983) [Pubmed]
  23. MHC class II-positive antigen-presenting cells in the decidua. Sargent, I., Starkey, P., Searle, R. Immunol. Today (1988) [Pubmed]
  24. Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis. Motro, B., Itin, A., Sachs, L., Keshet, E. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  25. Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis. Shweiki, D., Itin, A., Neufeld, G., Gitay-Goren, H., Keshet, E. J. Clin. Invest. (1993) [Pubmed]
  26. Induction of cytotoxic T-lymphocyte antigen-2beta, a cysteine protease inhibitor in decidua: a potential regulator of embryo implantation. Cheon, Y.P., DeMayo, F.J., Bagchi, M.K., Bagchi, I.C. J. Biol. Chem. (2004) [Pubmed]
  27. The expression of alpha(1)-acid glycoprotein mRNA during rat development. High levels of expression in the decidua. Thomas, T., Fletcher, S., Yeoh, G.C., Schreiber, G. J. Biol. Chem. (1989) [Pubmed]
  28. A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos. Nose, A., Takeichi, M. J. Cell Biol. (1986) [Pubmed]
  29. Variation in the HLA-G promoter region influences miscarriage rates. Ober, C., Aldrich, C.L., Chervoneva, I., Billstrand, C., Rahimov, F., Gray, H.L., Hyslop, T. Am. J. Hum. Genet. (2003) [Pubmed]
  30. CXCL12 expression by invasive trophoblasts induces the specific migration of CD16- human natural killer cells. Hanna, J., Wald, O., Goldman-Wohl, D., Prus, D., Markel, G., Gazit, R., Katz, G., Haimov-Kochman, R., Fujii, N., Yagel, S., Peled, A., Mandelboim, O. Blood (2003) [Pubmed]
  31. Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development. Johansson, B.M., Wiles, M.V. Mol. Cell. Biol. (1995) [Pubmed]
  32. Osteonectin/SPARC/BM-40 in human decidua and carcinoma, tissues characterized by de novo formation of basement membrane. Wewer, U.M., Albrechtsen, R., Fisher, L.W., Young, M.F., Termine, J.D. Am. J. Pathol. (1988) [Pubmed]
  33. The effect of mifepristone (RU486) on the immunohistochemical distribution of prostaglandin E and its metabolite in decidual and chorionic tissue in early pregnancy. Cheng, L., Kelly, R.W., Thong, K.J., Hume, R., Baird, D.T. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  34. The effect of mifepristone on the expression of steroid hormone receptors in human decidua and placenta: a randomized placebo-controlled double-blind study. Chan, C.C., Lao, T.T., Ho, P.C., Sung, E.O., Cheung, A.N. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  35. Human decidua is a target tissue for bradykinin and kallikrein: phosphoinositide hydrolysis accompanies arachidonic acid release in uterine decidua cells in vitro. Schrey, M.P., Holt, J.R., Cornford, P.A., Monaghan, H., al-Ubaidi, F. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
  36. Cellular localization of gonadotropin-releasing hormone (GnRH) I and GnRH II in first-trimester human placenta and decidua. Chou, C.S., Beristain, A.G., MacCalman, C.D., Leung, P.C. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
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