Chemical Compound Review:
AC1L986R (3S)-10,13-dimethyl- 2,3,4,5,6,7,8,9,11,12...
Synonyms:
C02945, 3beta-Hydroxysteroid
Young,
Clyne,
Cole,
Funder,
Cherradi,
Rossier,
Vallotton,
Timberg,
Friedberg,
Orly,
Wang,
Stocco,
Capponi,
Simard,
Ricketts,
Gingras,
Soucy,
Feltus,
Melner,
McNeilly,
Saunders,
Taggart,
Cranfield,
Cooke,
McNeilly,
Thomas,
Mason,
Brandt,
Spencer,
Norris,
Derry,
Gormally,
Means,
Zhao,
Meindl,
Kelley,
Boyd,
Herman,
Engeland,
Levay-Young,
Rogers,
Fitzgerald,
Thomas,
Boswell,
Scaccia,
Pletnev,
Umland,
Rahier,
Darnet,
Bouvier,
Camara,
Bard,
- The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits prostate cancer cell migration through activation of the estrogen receptor beta subtype. Guerini, V., Sau, D., Scaccianoce, E., Rusmini, P., Ciana, P., Maggi, A., Martini, P.G., Katzenellenbogen, B.S., Martini, L., Motta, M., Poletti, A. Cancer Res. (2005)
- Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2. Thomas, J.L., Boswell, E.L., Scaccia, L.A., Pletnev, V., Umland, T.C. J. Biol. Chem. (2005)
- A novel homozygous nonsense mutations E135* in the type II 3beta-hydroxysteroid dehydrogenase gene in a girl with salt-losing congenital adrenal hyperplasia. Mutations in brief no. 168. Online. Marui, S., Torrealba, I.M., Russell, A.J., Latronico, A.C., Sutcliffe, R.G., Mendonca, B.B. Hum. Mutat. (1998)
- Lack of defects in androgen production in children with hypospadias. Holmes, N.M., Miller, W.L., Baskin, L.S. J. Clin. Endocrinol. Metab. (2004)
- Refining hormonal diagnosis of type II 3beta-hydroxysteroid dehydrogenase deficiency in patients with premature pubarche and hirsutism based on HSD3B2 genotyping. Mermejo, L.M., Elias, L.L., Marui, S., Moreira, A.C., Mendonca, B.B., de Castro, M. J. Clin. Endocrinol. Metab. (2005)
- Abnormal serotonergic development in a mouse model for the Smith-Lemli-Opitz syndrome: implications for autism. Waage-Baudet, H., Lauder, J.M., Dehart, D.B., Kluckman, K., Hiller, S., Tint, G.S., Sulik, K.K. Int. J. Dev. Neurosci. (2003)
- The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase. Liu, X.Y., Dangel, A.W., Kelley, R.I., Zhao, W., Denny, P., Botcherby, M., Cattanach, B., Peters, J., Hunsicker, P.R., Mallon, A.M., Strivens, M.A., Bate, R., Miller, W., Rhodes, M., Brown, S.D., Herman, G.E. Nat. Genet. (1999)
- Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. jderry@immunex.com. Derry, J.M., Gormally, E., Means, G.D., Zhao, W., Meindl, A., Kelley, R.I., Boyd, Y., Herman, G.E. Nat. Genet. (1999)
- Molecular biology of the 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family. Simard, J., Ricketts, M.L., Gingras, S., Soucy, P., Feltus, F.A., Melner, M.H. Endocr. Rev. (2005)
- In humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual development. Goto, M., Piper Hanley, K., Marcos, J., Wood, P.J., Wright, S., Postle, A.D., Cameron, I.T., Mason, J.I., Wilson, D.I., Hanley, N.A. J. Clin. Invest. (2006)
- In search of rat stem Leydig cells: identification, isolation, and lineage-specific development. Ge, R.S., Dong, Q., Sottas, C.M., Papadopoulos, V., Zirkin, B.R., Hardy, M.P. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Expression of aromatase cytochrome P450 in rat H540 Leydig tumor cells. Young, M., Lephart, E.D., McPhaul, M.J. J. Steroid Biochem. Mol. Biol. (1997)
- Regulation of sex steroid formation by interleukin-4 and interleukin-6 in breast cancer cells. Turgeon, C., Gingras, S., Carrière, M.C., Blais, Y., Labrie, F., Simard, J. J. Steroid Biochem. Mol. Biol. (1998)
- Study of the effects of once daily doses of trilostane on cortisol concentrations and responsiveness to adrenocorticotrophic hormone in hyperadrenocorticoid dogs. Bell, R., Neiger, R., McGrotty, Y., Ramsey, I.K. Vet. Rec. (2006)
- Some enzymatic properties of 3beta-hydroxysteroid oxidase produced by Streptomyces violascens. Tomioka, H., Kagawa, M., Nakamura, S. J. Biochem. (1976)
- Regulation of cholesterol biosynthetic pathway in patients with the Smith-Lemli-Opitz syndrome. Honda, M., Tint, G.S., Honda, A., Salen, G., Shefer, S., Batta, A.K., Matsuzaki, Y., Tanaka, N. J. Inherit. Metab. Dis. (2000)
- Bone morphogenetic protein-15 inhibits follicle-stimulating hormone (FSH) action by suppressing FSH receptor expression. Otsuka, F., Yamamoto, S., Erickson, G.F., Shimasaki, S. J. Biol. Chem. (2001)
- Multiple signaling pathways mediate interleukin-4-induced 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene expression in human breast cancer cells. Gingras, S., Côté, S., Simard, J. Mol. Endocrinol. (2000)
- Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1. Peng, L., Huang, Y., Jin, F., Jiang, S.W., Payne, A.H. Mol. Endocrinol. (2004)
- Adrenarche results from development of a 3beta-hydroxysteroid dehydrogenase-deficient adrenal reticularis. Gell, J.S., Carr, B.R., Sasano, H., Atkins, B., Margraf, L., Mason, J.I., Rainey, W.E. J. Clin. Endocrinol. Metab. (1998)
- Newly proposed hormonal criteria via genotypic proof for type II 3beta-hydroxysteroid dehydrogenase deficiency. Lutfallah, C., Wang, W., Mason, J.I., Chang, Y.T., Haider, A., Rich, B., Castro-Magana, M., Copeland, K.C., David, R., Pang, S. J. Clin. Endocrinol. Metab. (2002)
- gamma-Aminobutyric acid, acting through gamma -aminobutyric acid type A receptors, inhibits the biosynthesis of neurosteroids in the frog hypothalamus. Do-Rego, J.L., Mensah-Nyagan, G.A., Beaujean, D., Vaudry, D., Sieghart, W., Luu-The, V., Pelletier, G., Vaudry, H. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Steroidogenesis in rabbit preimplantation embryos. Dickmann, Z., Dey, S.K., Gupta, J.S. Proc. Natl. Acad. Sci. U.S.A. (1975)
- Glucocorticoids and progestins signal the initiation and enhance the rate of myelin formation. Chan, J.R., Phillips, L.J., Glaser, M. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity. Thomas, J.L., Mason, J.I., Brandt, S., Spencer, B.R., Norris, W. J. Biol. Chem. (2002)
- Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein and cytochrome p450scc and 3beta-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa cells. Cherradi, N., Rossier, M.F., Vallotton, M.B., Timberg, R., Friedberg, I., Orly, J., Wang, X.J., Stocco, D.M., Capponi, A.M. J. Biol. Chem. (1997)
- Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3beta -hydroxysteroid dehydrogenase. Arlt, W., Auchus, R.J., Miller, W.L. J. Biol. Chem. (2001)
- Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action. Steckelbroeck, S., Jin, Y., Gopishetty, S., Oyesanmi, B., Penning, T.M. J. Biol. Chem. (2004)
- Molecular and Enzymatic Characterizations of Novel Bifunctional 3beta-Hydroxysteroid Dehydrogenases/C-4 Decarboxylases from Arabidopsis thaliana. Rahier, A., Darnet, S., Bouvier, F., Camara, B., Bard, M. J. Biol. Chem. (2006)
- Stat5-mediated regulation of the human type II 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene: activation by prolactin. Feltus, F.A., Groner, B., Melner, M.H. Mol. Endocrinol. (1999)
- GATA factors and the nuclear receptors, steroidogenic factor 1/liver receptor homolog 1, are key mutual partners in the regulation of the human 3beta-hydroxysteroid dehydrogenase type 2 promoter. Martin, L.J., Taniguchi, H., Robert, N.M., Simard, J., Tremblay, J.J., Viger, R.S. Mol. Endocrinol. (2005)
- Induction of 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene transcription in human breast cancer cell lines and in normal mammary epithelial cells by interleukin-4 and interleukin-13. Gingras, S., Moriggl, R., Groner, B., Simard, J. Mol. Endocrinol. (1999)
- Cardiac steroidogenesis in the normal and failing heart. Young, M.J., Clyne, C.D., Cole, T.J., Funder, J.W. J. Clin. Endocrinol. Metab. (2001)
- Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary. Luo, C.W., Pisarska, M.D., Hsueh, A.J. Endocrinology (2005)
- Cloning, expression, and physical mapping of the 3beta-hydroxysteroid dehydrogenase gene cluster (HSD3BP1-HSD3BP5) in human. McBride, M.W., McVie, A.J., Burridge, S.M., Brintnell, B., Craig, N., Wallace, A.M., Wilson, R.H., Varley, J., Sutcliffe, R.G. Genomics (1999)
- Bone morphogenetic protein inhibits ovarian androgen production. Dooley, C.A., Attia, G.R., Rainey, W.E., Moore, D.R., Carr, B.R. J. Clin. Endocrinol. Metab. (2000)
- Loss of oocytes in Dazl knockout mice results in maintained ovarian steroidogenic function but altered gonadotropin secretion in adult animals. McNeilly, J.R., Saunders, P.T., Taggart, M., Cranfield, M., Cooke, H.J., McNeilly, A.S. Endocrinology (2000)
- Tumor Necrosis Factor-{alpha} Regulates Steroidogenesis, Apoptosis, and Cell Viability in the Human Adrenocortical Cell Line NCI-H295R. Mikhaylova, I.V., Kuulasmaa, T., J????skel??inen, J., Voutilainen, R. Endocrinology (2007)
- Differential gene expression of cytochrome P450 11beta-hydroxylase in rat adrenal cortex after in vivo activation. Engeland, W.C., Levay-Young, B.K., Rogers, L.M., Fitzgerald, D. Endocrinology (1997)
- Effects of water restriction on gene expression in mouse renal medulla: identification of 3betaHSD4 as a collecting duct protein. Cai, Q., Keck, M., McReynolds, M.R., Klein, J.D., Greer, K., Sharma, K., Hoying, J.B., Sands, J.M., Brooks, H.L. Am. J. Physiol. Renal Physiol. (2006)