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Chemical Compound Review

AC1L986R     (3S)-10,13-dimethyl- 2,3,4,5,6,7,8,9,11,12...

Synonyms: C02945, 3beta-Hydroxysteroid
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Disease relevance of C02945

  • These results also shed some light on clinical observations suggesting that alterations in genes coding for 3beta-hydroxysteroid dehydrogenases (the enzymes responsible for 3beta-Adiol formation) are strongly correlated with hereditary prostate cancer [1].
  • The human type 1 (placenta, breast tumors, and prostate tumors) and type 2 (adrenals and gonads) isoforms of 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1 and 3beta-HSD2) are encoded by two distinct genes that are expressed in a tissue-specific pattern [2].
  • A novel homozygous nonsense mutations E135* in the type II 3beta-hydroxysteroid dehydrogenase gene in a girl with salt-losing congenital adrenal hyperplasia. Mutations in brief no. 168. Online [3].
  • To determine whether defects exist in the production of androgens in individuals with hypospadias, we examined enzymatic function of 3beta-hydroxysteroid dehydrogenase (3betaHSD), P450c17 (17alpha-hydroxylase and 17,20 lyase activity), and type 3 17betaHSD [4].
  • Refining hormonal diagnosis of type II 3beta-hydroxysteroid dehydrogenase deficiency in patients with premature pubarche and hirsutism based on HSD3B2 genotyping [5].

Psychiatry related information on C02945


High impact information on C02945


Chemical compound and disease context of C02945


Biological context of C02945


Anatomical context of C02945

  • In the present report, we have attempted to determine whether 3beta-hydroxysteroid dehydrogenase (3beta-HSD)-containing neurons, which secrete neurosteroids in the frog hypothalamus, also express the GABA(A) receptor, and we have investigated the effect of GABA on neurosteroid biosynthesis by frog hypothalamic explants [22].
  • 3beta-Hydroxysteroid dehydrogenase activity began at 48 hr and was sustained through the late blastocyst stage (144 hr), with the exception of a brief drop, possibly cessation, of activity at 72 hr [23].
  • The mRNA for cytochrome P450scc and 3beta-hydroxysteroid dehydrogenase also were found to be induced during the differentiation of O-2A precursor cells to oligodendrocytes [24].
  • Two distinct genes encode the 93% homologous type 1 (placenta, peripheral tissues) and type 2 (adrenals, gonads) 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD/isomerase) in humans [25].
  • Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein and cytochrome p450scc and 3beta-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa cells [26].

Associations of C02945 with other chemical compounds


Gene context of C02945


Analytical, diagnostic and therapeutic context of C02945

  • The expression of 17alpha-hydroxylase (CYP17), 3beta-hydroxysteroid dehydrogenase (3betaHSD), cholesterol side-chain cleavage (CYP11A1), and steroidogenic acute regulatory (StAR) protein was determined by protein immunoblotting analysis using specific rabbit polyclonal antibodies [36].
  • However, by immunocytochemistry, there are cells positive for 3beta-hydroxysteroid dehydrogenase, 17alpha-hydroxylase, and aromatase, indicating the presence of steroidogenically active cells capable of producing estrogen [37].
  • This was accompanied by a parallel increase in the expression of the genes encoding for the steroidogenic acute regulatory protein, 3beta-hydroxysteroid dehydrogenase 2, and 17-hydroxylase/17,20-lyase (74, 200, and 50%, respectively; quantitative real-time RT-PCR analysis) [38].
  • In situ hybridization histochemistry was used to monitor the expression of 3beta-hydroxysteroid dehydrogenase, delta4-isomerase (3betaHSD) and cytochrome P450 11beta-hydroxylase (P45011beta) messenger RNA (mRNA) in adult rat adrenals after stimulation in vivo [39].
  • The steroid hormone enzyme 3beta-hydroxysteroid dehydrogenase 4 (3betaHSD4) was identified as a novel target of vasopressin regulation, and via dual labeling immunofluorescence we colocalized the expression of this protein to AQP2-expressing collecting ducts of the kidney [40].


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  10. In humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual development. Goto, M., Piper Hanley, K., Marcos, J., Wood, P.J., Wright, S., Postle, A.D., Cameron, I.T., Mason, J.I., Wilson, D.I., Hanley, N.A. J. Clin. Invest. (2006) [Pubmed]
  11. In search of rat stem Leydig cells: identification, isolation, and lineage-specific development. Ge, R.S., Dong, Q., Sottas, C.M., Papadopoulos, V., Zirkin, B.R., Hardy, M.P. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  12. Expression of aromatase cytochrome P450 in rat H540 Leydig tumor cells. Young, M., Lephart, E.D., McPhaul, M.J. J. Steroid Biochem. Mol. Biol. (1997) [Pubmed]
  13. Regulation of sex steroid formation by interleukin-4 and interleukin-6 in breast cancer cells. Turgeon, C., Gingras, S., Carrière, M.C., Blais, Y., Labrie, F., Simard, J. J. Steroid Biochem. Mol. Biol. (1998) [Pubmed]
  14. Study of the effects of once daily doses of trilostane on cortisol concentrations and responsiveness to adrenocorticotrophic hormone in hyperadrenocorticoid dogs. Bell, R., Neiger, R., McGrotty, Y., Ramsey, I.K. Vet. Rec. (2006) [Pubmed]
  15. Some enzymatic properties of 3beta-hydroxysteroid oxidase produced by Streptomyces violascens. Tomioka, H., Kagawa, M., Nakamura, S. J. Biochem. (1976) [Pubmed]
  16. Regulation of cholesterol biosynthetic pathway in patients with the Smith-Lemli-Opitz syndrome. Honda, M., Tint, G.S., Honda, A., Salen, G., Shefer, S., Batta, A.K., Matsuzaki, Y., Tanaka, N. J. Inherit. Metab. Dis. (2000) [Pubmed]
  17. Bone morphogenetic protein-15 inhibits follicle-stimulating hormone (FSH) action by suppressing FSH receptor expression. Otsuka, F., Yamamoto, S., Erickson, G.F., Shimasaki, S. J. Biol. Chem. (2001) [Pubmed]
  18. Multiple signaling pathways mediate interleukin-4-induced 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene expression in human breast cancer cells. Gingras, S., Côté, S., Simard, J. Mol. Endocrinol. (2000) [Pubmed]
  19. Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1. Peng, L., Huang, Y., Jin, F., Jiang, S.W., Payne, A.H. Mol. Endocrinol. (2004) [Pubmed]
  20. Adrenarche results from development of a 3beta-hydroxysteroid dehydrogenase-deficient adrenal reticularis. Gell, J.S., Carr, B.R., Sasano, H., Atkins, B., Margraf, L., Mason, J.I., Rainey, W.E. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  21. Newly proposed hormonal criteria via genotypic proof for type II 3beta-hydroxysteroid dehydrogenase deficiency. Lutfallah, C., Wang, W., Mason, J.I., Chang, Y.T., Haider, A., Rich, B., Castro-Magana, M., Copeland, K.C., David, R., Pang, S. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  22. gamma-Aminobutyric acid, acting through gamma -aminobutyric acid type A receptors, inhibits the biosynthesis of neurosteroids in the frog hypothalamus. Do-Rego, J.L., Mensah-Nyagan, G.A., Beaujean, D., Vaudry, D., Sieghart, W., Luu-The, V., Pelletier, G., Vaudry, H. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
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  25. Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity. Thomas, J.L., Mason, J.I., Brandt, S., Spencer, B.R., Norris, W. J. Biol. Chem. (2002) [Pubmed]
  26. Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein and cytochrome p450scc and 3beta-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa cells. Cherradi, N., Rossier, M.F., Vallotton, M.B., Timberg, R., Friedberg, I., Orly, J., Wang, X.J., Stocco, D.M., Capponi, A.M. J. Biol. Chem. (1997) [Pubmed]
  27. Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3beta -hydroxysteroid dehydrogenase. Arlt, W., Auchus, R.J., Miller, W.L. J. Biol. Chem. (2001) [Pubmed]
  28. Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action. Steckelbroeck, S., Jin, Y., Gopishetty, S., Oyesanmi, B., Penning, T.M. J. Biol. Chem. (2004) [Pubmed]
  29. Molecular and Enzymatic Characterizations of Novel Bifunctional 3beta-Hydroxysteroid Dehydrogenases/C-4 Decarboxylases from Arabidopsis thaliana. Rahier, A., Darnet, S., Bouvier, F., Camara, B., Bard, M. J. Biol. Chem. (2006) [Pubmed]
  30. Stat5-mediated regulation of the human type II 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene: activation by prolactin. Feltus, F.A., Groner, B., Melner, M.H. Mol. Endocrinol. (1999) [Pubmed]
  31. GATA factors and the nuclear receptors, steroidogenic factor 1/liver receptor homolog 1, are key mutual partners in the regulation of the human 3beta-hydroxysteroid dehydrogenase type 2 promoter. Martin, L.J., Taniguchi, H., Robert, N.M., Simard, J., Tremblay, J.J., Viger, R.S. Mol. Endocrinol. (2005) [Pubmed]
  32. Induction of 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene transcription in human breast cancer cell lines and in normal mammary epithelial cells by interleukin-4 and interleukin-13. Gingras, S., Moriggl, R., Groner, B., Simard, J. Mol. Endocrinol. (1999) [Pubmed]
  33. Cardiac steroidogenesis in the normal and failing heart. Young, M.J., Clyne, C.D., Cole, T.J., Funder, J.W. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  34. Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary. Luo, C.W., Pisarska, M.D., Hsueh, A.J. Endocrinology (2005) [Pubmed]
  35. Cloning, expression, and physical mapping of the 3beta-hydroxysteroid dehydrogenase gene cluster (HSD3BP1-HSD3BP5) in human. McBride, M.W., McVie, A.J., Burridge, S.M., Brintnell, B., Craig, N., Wallace, A.M., Wilson, R.H., Varley, J., Sutcliffe, R.G. Genomics (1999) [Pubmed]
  36. Bone morphogenetic protein inhibits ovarian androgen production. Dooley, C.A., Attia, G.R., Rainey, W.E., Moore, D.R., Carr, B.R. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  37. Loss of oocytes in Dazl knockout mice results in maintained ovarian steroidogenic function but altered gonadotropin secretion in adult animals. McNeilly, J.R., Saunders, P.T., Taggart, M., Cranfield, M., Cooke, H.J., McNeilly, A.S. Endocrinology (2000) [Pubmed]
  38. Tumor Necrosis Factor-{alpha} Regulates Steroidogenesis, Apoptosis, and Cell Viability in the Human Adrenocortical Cell Line NCI-H295R. Mikhaylova, I.V., Kuulasmaa, T., J????skel??inen, J., Voutilainen, R. Endocrinology (2007) [Pubmed]
  39. Differential gene expression of cytochrome P450 11beta-hydroxylase in rat adrenal cortex after in vivo activation. Engeland, W.C., Levay-Young, B.K., Rogers, L.M., Fitzgerald, D. Endocrinology (1997) [Pubmed]
  40. Effects of water restriction on gene expression in mouse renal medulla: identification of 3betaHSD4 as a collecting duct protein. Cai, Q., Keck, M., McReynolds, M.R., Klein, J.D., Greer, K., Sharma, K., Hoying, J.B., Sands, J.M., Brooks, H.L. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
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