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Gene Review

ADSS  -  adenylosuccinate synthase

Homo sapiens

Synonyms: ADEH, ADSS 2, ADSS2, AMPSase 2, AdSS 2, ...
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Disease relevance of ADSS


High impact information on ADSS

  • This is supported by the experiments in which the cells were alternately incubated with nitrogen or oxygen, demonstrating that hadacidin significantly decreased utilization of aspartate and regeneration of ATP owing to inhibition of adenylosuccinate synthase [2].
  • The Ade -H mutant is defective in the enzyme adenylosuccinate (AMPS) synthetase (ADSS; EC, which carries out the first of a two-step sequence in the biosynthesis of AMP from IMP, and therefore requires exogenous adenine for growth [3].
  • In summary, we have shown by cytogenetics, segregant analysis, biochemical assay, and Southern blot analysis that human chromosome 1, most likely in the region 1cen-1q12, corrects the defect in ADSS-deficient mutant Ade-H cells [3].
  • The same organisms convert another inosine analog, formycin B, to the ribonucleotide, but its inhibitory effects appear to be exercised primarily by inhibition of the organism's adenylosuccinate synthase [4].
  • This is consistent with significantly higher activities (two to five-fold) of the key regulatory enzymes of the de novo purine synthesis pathway (PRPP synthetase, amido-phosphoribosyl transferase and adenylosuccinate synthase) in the undifferentiated cells [5].

Other interactions of ADSS

  • Batch equilibrium sorption experiments were used for screening for cost-effective four types of sludge, which were DWS (drinking water treatment plant sludge), LLS (landfill leachate sludge), ADSS (anaerobically digested sewage sludge), and SS (sewage sludge) [6].


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