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Gene Review

DGKG  -  diacylglycerol kinase, gamma 90kDa

Homo sapiens

Synonyms: DAG kinase gamma, DAGK3, DGK-GAMMA, DGK-gamma, Diacylglycerol kinase gamma, ...
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Disease relevance of DGKG


High impact information on DGKG

  • The amino acid sequence of DGK gamma was 52 and 62% identical to those of previously sequenced porcine 80-kDa and rat 90-kDa enzymes, respectively [2].
  • In contrast the truncated cDNA failed to give DGK activity in spite of the expression of its mRNA and enzyme protein in COS cells, thus demonstrating that the truncated DGK gamma is catalytically inactive [2].
  • DGK gamma, although initially cloned from the HepG2 cDNA libraries, was unexpectedly expressed in the human retina abundantly and to a much lesser extent in the brain [2].
  • However, at least five alternative types of high-affinity diacylglycerol/phorbol-ester receptor are known: chimaerins, protein kinase D, RasGRPs, Munc13s and DAG kinase gamma [3].
  • In the present study, we report the genomic organization of the human DAGK3 gene, which spans over 30 kb of genomic DNA interrupted by 23 introns [1].

Biological context of DGKG


Other interactions of DGKG


  1. Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1). Stöhr, H., Klein, J., Gehrig, A., Koehler, M.R., Jurklies, B., Kellner, U., Leo-Kottler, B., Schmid, M., Weber, B.H. Hum. Genet. (1999) [Pubmed]
  2. Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells. Kai, M., Sakane, F., Imai, S., Wada, I., Kanoh, H. J. Biol. Chem. (1994) [Pubmed]
  3. Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters. Brose, N., Rosenmund, C. J. Cell. Sci. (2002) [Pubmed]
  4. Diacylglycerol kinase gamma is one of the specific receptors of tumor-promoting phorbol esters. Shindo, M., Irie, K., Ohigashi, H., Kuriyama, M., Saito, N. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  5. Localisation of the gene encoding diacylglycerol kinase 3 (DAGK3) to human chromosome 3q27-28 and mouse chromosome 16. Fitzgibbon, J., Wells, D., Pilz, A., Delhanty, J., Kai, M., Kanoh, H., Hunt, D. Curr. Eye Res. (1995) [Pubmed]
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