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Gene Review

DGKB  -  diacylglycerol kinase, beta 90kDa

Homo sapiens

Synonyms: 90 kDa diacylglycerol kinase, DAG kinase beta, DAGK2, DGK, DGK-BETA, ...
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Disease relevance of DGKB

  • It has been previously reported that DGK inhibited GPCR agonist-induced activation of the DAG-PKC signaling and subsequent cardiomyocyte hypertrophy, so the purpose of this study was to examine whether DGK modifies the development of cardiac hypertrophy induced by pressure overload [1].

High impact information on DGKB

  • Diacylglycerol kinases (DGKs), which negatively regulate Ras activity, were upregulated in anergic T cells, and a DGK inhibitor restored interleukin 2 production in anergic T cells [2].
  • Our data support a causal function for excess DGK activity and defective Ras signaling in T cell anergy [2].
  • Receptor-mediated increase in 1,2-diacylglycerol (DG) levels is attenuated by DG kinase and DG lipase [3].
  • Diacylglycerol (DAG) acts as an allosteric activator of protein kinase C (PKC) and is converted to phosphatidic acid by DAG kinase (DGK) [4].
  • This study also suggests that DGKbeta plays a prominent role in regulation of O(2)(-) production during FcgammaR-mediated phagocytosis [5].

Biological context of DGKB


Anatomical context of DGKB

  • DGKgamma localized in the cytosol while DGKbeta localized along the membrane structure [8].
  • In the hippocampal pyramidal cell, both DGKbeta and gamma were abundant but subcellular localization was different [8].
  • Under these conditions, broken (leaky) ROS prepared by continuous sucrose gradient centrifugation showed PI, PIP and DG kinase activities similar to those found in intact ROS and non-ROS membranes, whereas PI synthetase activity was much lower in the leaky ROS than in the other two fractions [9].

Associations of DGKB with chemical compounds

  • Furthermore, our synthetic approach with the PKC C1 homology domains clarified that diacylglycerol kinase beta and gamma are new targets of phorbol esters [10].
  • Inhibiting the enzyme diacylglycerol (DG) kinase in effector cells with 10 microM R59022 (DG kinase inhibitor) potentiates NK killing, suggesting an increase in protein kinase C (PKC) activity due to accumulation of DG [11].

Other interactions of DGKB

  • The proximal breakpoint was found to lie between exon 6 and exon 7 of KIAA0744, and the distal breakpoint lay between exon 17 and exon 18 of DGKB [12].

Analytical, diagnostic and therapeutic context of DGKB


  1. Diacylglycerol Kinase xi Attenuates Pressure Overload-Induced Cardiac Hypertrophy. Harada, M., Takeishi, Y., Arimoto, T., Niizeki, T., Kitahara, T., Goto, K., Walsh, R.A., Kubota, I. Circ. J. (2007) [Pubmed]
  2. T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha. Zha, Y., Marks, R., Ho, A.W., Peterson, A.C., Janardhan, S., Brown, I., Praveen, K., Stang, S., Stone, J.C., Gajewski, T.F. Nat. Immunol. (2006) [Pubmed]
  3. Rapid attenuation of receptor-induced diacylglycerol and phosphatidic acid by phospholipase D-mediated transphosphatidylation: formation of bisphosphatidic acid. van Blitterswijk, W.J., Hilkmann, H. EMBO J. (1993) [Pubmed]
  4. Phosphorylation and Up-regulation of Diacylglycerol Kinase {gamma} via Its Interaction with Protein Kinase C{gamma}. Yamaguchi, Y., Shirai, Y., Matsubara, T., Sanse, K., Kuriyama, M., Oshiro, N., Yoshino, K., Yonezawa, K., Ono, Y., Saito, N. J. Biol. Chem. (2006) [Pubmed]
  5. Superoxide production at phagosomal cup/phagosome through beta I protein kinase C during Fc gamma R-mediated phagocytosis in microglia. Ueyama, T., Lennartz, M.R., Noda, Y., Kobayashi, T., Shirai, Y., Rikitake, K., Yamasaki, T., Hayashi, S., Sakai, N., Seguchi, H., Sawada, M., Sumimoto, H., Saito, N. J. Immunol. (2004) [Pubmed]
  6. Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties. Caricasole, A., Bettini, E., Sala, C., Roncarati, R., Kobayashi, N., Caldara, F., Goto, K., Terstappen, G.C. J. Biol. Chem. (2002) [Pubmed]
  7. Localisation of the gene encoding diacylglycerol kinase 3 (DAGK3) to human chromosome 3q27-28 and mouse chromosome 16. Fitzgibbon, J., Wells, D., Pilz, A., Delhanty, J., Kai, M., Kanoh, H., Hunt, D. Curr. Eye Res. (1995) [Pubmed]
  8. Immunocytochemical localization of a neuron-specific diacylglycerol kinase beta and gamma in the developing rat brain. Adachi, N., Oyasu, M., Taniguchi, T., Yamaguchi, Y., Takenaka, R., Shirai, Y., Saito, N. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  9. Phosphoinositide metabolism in frog rod outer segments. Choe, H.G., Ghalayini, A.J., Anderson, R.E. Exp. Eye Res. (1990) [Pubmed]
  10. Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes. Irie, K., Nakagawa, Y., Ohigashi, H. Curr. Pharm. Des. (2004) [Pubmed]
  11. A central role for phosphoinositide hydrolysis in activating the lytic mechanism of human natural killer cells. Chow, S.C., Jondal, M. Immunology (1990) [Pubmed]
  12. Molecular characterization of a 7p15-21 homozygous deletion in a Wilms tumor. Sossey-Alaoui, K., Vieira, L., David, D., Boavida, M.G., Cowell, J.K. Genes Chromosomes Cancer (2003) [Pubmed]
  13. Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons. Goto, K., Kondo, H. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
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