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Gene Review:

Il17ra - interleukin 17 receptor A

Mus musculus

Synonyms: AW538159, Cdw217, IL-17 receptor A, IL-17RA, Il17r, ...

Ye, P. et al., Lubberts, E. et al., Schnyder, B. et al.

Lubberts, Schwarzenberger, Huang, Schurr, Peschon, van den Berg, Kolls,

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Disease relevance of Il17ra

These data support impaired IL-17R signaling as a potential mechanism by which deficiency of CD4 lymphocytes predisposes to bacterial pneumonia [1].
To test this, we used a model of Klebsiella pneumoniae lung infection in mice genetically deficient in IL-17R or in mice overexpressing a soluble IL-17R [1].
Requirement of IL-17 receptor signaling in radiation-resistant cells in the joint for full progression of destructive synovitis [2].

High impact information on Il17ra

Thus, IL-17R signaling is critical for optimal production of G-CSF and MIP-2 and local control of pulmonary K. pneumoniae infection [1].
IL-17R knockout (KO) mice displayed a significant delay in neutrophil recruitment into the alveolar space, and had greater dissemination of K. pneumoniae compared with control mice [1].
Neutralization of the human IL-17 receptor (IL-17R) by M202 antibody competitively reverses the IL-17-induced IL-6 upregulation [3].

Other interactions of Il17ra

This defect was associated with a significant reduction in steady-state levels of G-CSF and macrophage inflammatory protein (MIP)-2 mRNA and protein in the lung in response to the K. pneumoniae challenge in IL-17R KO mice [1].

References

Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. Ye, P., Rodriguez, F.H., Kanaly, S., Stocking, K.L., Schurr, J., Schwarzenberger, P., Oliver, P., Huang, W., Zhang, P., Zhang, J., Shellito, J.E., Bagby, G.J., Nelson, S., Charrier, K., Peschon, J.J., Kolls, J.K. J. Exp. Med. (2001) [Pubmed]
Requirement of IL-17 receptor signaling in radiation-resistant cells in the joint for full progression of destructive synovitis. Lubberts, E., Schwarzenberger, P., Huang, W., Schurr, J.R., Peschon, J.J., van den Berg, W.B., Kolls, J.K. J. Immunol. (2005) [Pubmed]
IL-17 reduces TNF-induced Rantes and VCAM-1 expression. Schnyder, B., Schnyder-Candrian, S., Pansky, A., Schmitz, M.L., Heim, M., Ryffel, B., Moser, R. Cytokine (2005) [Pubmed]

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