Gene Review:
Cxcl2 - chemokine (C-X-C motif) ligand 2
Mus musculus
Synonyms:
C-X-C motif chemokine 2, CINC-2a, GROb, Gro2, MIP-2, ...
Schaefer,
Babelova,
Kiss,
Hausser,
Baliova,
Krzyzankova,
Marsche,
Young,
Mihalik,
Götte,
Malle,
Schaefer,
Gröne,
Amano,
Yamamoto,
Senba,
Oishi,
Suzuki,
Fukushima,
Mukaida,
Matsushima,
Eguchi,
Nagatake,
Rousseau,
Morrice,
Peggie,
Campbell,
Gaestel,
Cohen,
Maheshwari,
Christensen,
Calhoun,
Dimmitt,
Lacson,
Maus,
Huwe,
Maus,
Seeger,
Lohmeyer,
Xing,
Gauldie,
Cox,
Baumann,
Jordana,
Lei,
Achong,
Matsukawa,
Kudo,
Maeda,
Numata,
Watanabe,
Takeda,
Akira,
Ito,
- Macrophage inflammatory protein-2 and KC induce chemokine production by mouse astrocytes. Luo, Y., Fischer, F.R., Hancock, W.W., Dorf, M.E. J. Immunol. (2000)
- Alveolar JE/MCP-1 and endotoxin synergize to provoke lung cytokine upregulation, sequential neutrophil and monocyte influx, and vascular leakage in mice. Maus, U., Huwe, J., Maus, R., Seeger, W., Lohmeyer, J. Am. J. Respir. Crit. Care Med. (2001)
- Elevated levels of macrophage inflammatory protein 2 in severe murine peritonitis increase neutrophil recruitment and mortality. Walley, K.R., Lukacs, N.W., Standiford, T.J., Strieter, R.M., Kunkel, S.L. Infect. Immun. (1997)
- Chemokine expression in myocardial ischemia: MIP-2 dependent MCP-1 expression protects cardiomyocytes from cell death. Tarzami, S.T., Cheng, R., Miao, W., Kitsis, R.N., Berman, J.W. J. Mol. Cell. Cardiol. (2002)
- The contribution of accessory toxins of Vibrio cholerae O1 El Tor to the proinflammatory response in a murine pulmonary cholera model. Fullner, K.J., Boucher, J.C., Hanes, M.A., Haines, G.K., Meehan, B.M., Walchle, C., Sansonetti, P.J., Mekalanos, J.J. J. Exp. Med. (2002)
- Involvement of Interleukin (IL) 8 receptor in negative regulation of myeloid progenitor cells in vivo: evidence from mice lacking the murine IL-8 receptor homologue. Broxmeyer, H.E., Cooper, S., Cacalano, G., Hague, N.L., Bailish, E., Moore, M.W. J. Exp. Med. (1996)
- The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. Schaefer, L., Babelova, A., Kiss, E., Hausser, H.J., Baliova, M., Krzyzankova, M., Marsche, G., Young, M.F., Mihalik, D., Götte, M., Malle, E., Schaefer, R.M., Gröne, H.J. J. Clin. Invest. (2005)
- Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis. Spergel, J.M., Mizoguchi, E., Oettgen, H., Bhan, A.K., Geha, R.S. J. Clin. Invest. (1999)
- IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. Xing, Z., Gauldie, J., Cox, G., Baumann, H., Jordana, M., Lei, X.F., Achong, M.K. J. Clin. Invest. (1998)
- Involvement of the neuropeptide substance P in lung inflammation induced by hepatic ischemia/reperfusion. Okaya, T., Holthaus, R., Kato, A., Lentsch, A.B. Inflamm. Res. (2004)
- Poly(ADP-ribose) polymerase is a regulator of chemokine production: relevance for the pathogenesis of shock and inflammation. Haskó, G., Mabley, J.G., Németh, Z.H., Pacher, P., Deitch, E.A., Szabó, C. Mol. Med. (2002)
- Impairment of endotoxin-induced macrophage inflammatory protein 2 gene expression in alveolar macrophages in streptozotocin-induced diabetes in mice. Amano, H., Yamamoto, H., Senba, M., Oishi, K., Suzuki, S., Fukushima, K., Mukaida, N., Matsushima, K., Eguchi, K., Nagatake, T. Infect. Immun. (2000)
- Administration of isoferulic acid improved the survival rate of lethal influenza virus pneumonia in mice. Sakai, S., Ochiai, H., Mantani, N., Kogure, T., Shibahara, N., Terasawa, K. Mediators of inflammation. (2001)
- Upregulation of MIP-2 (CXCL2) expression by 15-deoxy-Delta(12,14)-prostaglandin J(2) in mouse peritoneal macrophages. Kim, H.Y., Kim, H.S. Immunol. Cell Biol. (2007)
- Role of chemokines and formyl peptides in pneumococcal pneumonia-induced monocyte/macrophage recruitment. Fillion, I., Ouellet, N., Simard, M., Bergeron, Y., Sato, S., Bergeron, M.G. J. Immunol. (2001)
- Macrophage inflammatory protein 2 inhibits beta-amyloid peptide (1-42)-mediated hippocampal neuronal apoptosis through activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways. Watson, K., Fan, G.H. Mol. Pharmacol. (2005)
- Oxygen radical-dependent expression of CXC chemokines regulate ischemia/reperfusion-induced leukocyte adhesion in the mouse colon. Riaz, A.A., Schramm, R., Sato, T., Menger, M.D., Jeppsson, B., Thorlacius, H. Free Radic. Biol. Med. (2003)
- Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. Rousseau, S., Morrice, N., Peggie, M., Campbell, D.G., Gaestel, M., Cohen, P. EMBO J. (2002)
- Fas signal links innate and adaptive immunity by promoting dendritic-cell secretion of CC and CXC chemokines. Guo, Z., Zhang, M., Tang, H., Cao, X. Blood (2005)
- Distinct temporal patterns of macrophage-inflammatory protein-2 and KC chemokine gene expression in surgical injury. Endlich, B., Armstrong, D., Brodsky, J., Novotny, M., Hamilton, T.A. J. Immunol. (2002)
- LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. Aung, H.T., Schroder, K., Himes, S.R., Brion, K., van Zuylen, W., Trieu, A., Suzuki, H., Hayashizaki, Y., Hume, D.A., Sweet, M.J., Ravasi, T. FASEB J. (2006)
- Stat3 in resident macrophages as a repressor protein of inflammatory response. Matsukawa, A., Kudo, S., Maeda, T., Numata, K., Watanabe, H., Takeda, K., Akira, S., Ito, T. J. Immunol. (2005)
- Inosine reduces systemic inflammation and improves survival in septic shock induced by cecal ligation and puncture. Liaudet, L., Mabley, J.G., Soriano, F.G., Pacher, P., Marton, A., Haskó, G., Szabó, C. Am. J. Respir. Crit. Care Med. (2001)
- Generation and functional significance of CXC chemokines for neutrophil-induced liver injury during endotoxemia. Dorman, R.B., Gujral, J.S., Bajt, M.L., Farhood, A., Jaeschke, H. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)
- 17 beta-estradiol inhibits cytokine, chemokine, and chemokine receptor mRNA expression in the central nervous system of female mice with experimental autoimmune encephalomyelitis. Matejuk, A., Adlard, K., Zamora, A., Silverman, M., Vandenbark, A.A., Offner, H. J. Neurosci. Res. (2001)
- Hypoxia induces macrophage inflammatory protein-2 (MIP-2) gene expression in murine macrophages via NF-kappaB: the prominent role of p42/ p44 and PI3 kinase pathways. Zampetaki, A., Mitsialis, S.A., Pfeilschifter, J., Kourembanas, S. FASEB J. (2004)
- Increased pulmonary responses to acute ozone exposure in obese db/db mice. Lu, F.L., Johnston, R.A., Flynt, L., Theman, T.A., Terry, R.D., Schwartzman, I.N., Lee, A., Shore, S.A. Am. J. Physiol. Lung Cell Mol. Physiol. (2006)
- Autocrine action of IL-10 suppresses proinflammatory mediators and inflammation in the HSV-1-infected cornea. Yan, X.T., Zhuang, M., Oakes, J.E., Lausch, R.N. J. Leukoc. Biol. (2001)
- Interleukin-10 mediates the protective effect of Linomide by reducing CXC chemokine production in endotoxin-induced liver injury. Li, X., Klintman, D., Sato, T., Hedlund, G., Schramm, R., Jeppsson, B., Thorlacius, H. Br. J. Pharmacol. (2004)
- Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. Kasama, T., Strieter, R.M., Lukacs, N.W., Lincoln, P.M., Burdick, M.D., Kunkel, S.L. J. Clin. Invest. (1995)
- Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung. Wang, X., Moser, C., Louboutin, J.P., Lysenko, E.S., Weiner, D.J., Weiser, J.N., Wilson, J.M. J. Immunol. (2002)
- Chemokine amplification in mesangial cells. Luo, Y., Lloyd, C., Gutierrez-Ramos, J.C., Dorf, M.E. J. Immunol. (1999)
- Resident cell chemokine expression serves as the major mechanism for leukocyte recruitment during local inflammation. García-Ramallo, E., Marques, T., Prats, N., Beleta, J., Kunkel, S.L., Godessart, N. J. Immunol. (2002)
- Circulating CXC-chemokine concentrations in a murine intestinal ischemia-reperfusion model. Maheshwari, A., Christensen, R.D., Calhoun, D.A., Dimmitt, R.A., Lacson, A. Fetal and pediatric pathology. (2004)
- Mitogenic properties of endogenous and pharmacological doses of macrophage inflammatory protein-2 after 70% hepatectomy in the mouse. Ren, X., Carpenter, A., Hogaboam, C., Colletti, L. Am. J. Pathol. (2003)