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Gene Review

IL17RA  -  interleukin 17 receptor A

Homo sapiens

Synonyms: CANDF5, CD217, CDw217, IL-17 receptor A, IL-17RA, ...
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Disease relevance of IL17RA


High impact information on IL17RA

  • Whereas expression of IL-17 is restricted to activated T cells, the IL-17 receptor is found to be widely expressed, a finding consistent with the pleiotropic activities of IL-17 [5].
  • Strikingly, treatment with IL-17A or IL-17F markedly reduced FRET efficiency, suggesting that IL-17RA subunits within the IL-17R complex undergo a conformational change upon ligand binding [6].
  • We used fluorescence resonance energy transfer (FRET) to determine whether IL-17RA subunits multimerize, and, if so, whether they are preassembled in the plasma membrane [6].
  • We demonstrate here that IL-17 receptor family shares sequence homology in their intracellular region with Toll-IL-1 receptor (TIR) domains and with Act1, a novel adaptor previously reported as an NF-kappaB activator [7].
  • Based on sequence and functional similarities, this novel IL-17 receptor homologue represents a potential human SEF and is likely to play critical roles in endothelial or epithelial functions such as proliferation, migration, and angiogenesis [8].

Biological context of IL17RA


Anatomical context of IL17RA


Physical interactions of IL17RA

  • Binding studies suggest that recombinant hIL-17 binds to the hIL-17R with low affinity [9].

Other interactions of IL17RA


Analytical, diagnostic and therapeutic context of IL17RA


  1. Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. McAllister, F., Henry, A., Kreindler, J.L., Dubin, P.J., Ulrich, L., Steele, C., Finder, J.D., Pilewski, J.M., Carreno, B.M., Goldman, S.J., Pirhonen, J., Kolls, J.K. J. Immunol. (2005) [Pubmed]
  2. High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chondrocytes from arthritis patients. Honorati, M.C., Meliconi, R., Pulsatelli, L., Canè, S., Frizziero, L., Facchini, A. Rheumatology (Oxford, England) (2001) [Pubmed]
  3. IL-17 enhances the susceptibility of U-2 OS osteosarcoma cells to NK cell lysis. Honorati, M.C., Neri, S., Cattini, L., Facchini, A. Clin. Exp. Immunol. (2003) [Pubmed]
  4. Expression profile of immune-associated genes in nasal polyps. Wang, X., Dong, Z., Zhu, D.D., Guan, B. Ann. Otol. Rhinol. Laryngol. (2006) [Pubmed]
  5. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. Li, H., Chen, J., Huang, A., Stinson, J., Heldens, S., Foster, J., Dowd, P., Gurney, A.L., Wood, W.I. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  6. Evidence for ligand-independent multimerization of the IL-17 receptor. Kramer, J.M., Yi, L., Shen, F., Maitra, A., Jiao, X., Jin, T., Gaffen, S.L. J. Immunol. (2006) [Pubmed]
  7. Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor. Chang, S.H., Park, H., Dong, C. J. Biol. Chem. (2006) [Pubmed]
  8. A novel interleukin-17 receptor-like protein identified in human umbilical vein endothelial cells antagonizes basic fibroblast growth factor-induced signaling. Yang, R.B., Ng, C.K., Wasserman, S.M., Kömüves, L.G., Gerritsen, M.E., Topper, J.N. J. Biol. Chem. (2003) [Pubmed]
  9. Molecular characterization of the human interleukin (IL)-17 receptor. Yao, Z., Spriggs, M.K., Derry, J.M., Strockbine, L., Park, L.S., VandenBos, T., Zappone, J.D., Painter, S.L., Armitage, R.J. Cytokine (1997) [Pubmed]
  10. Interleukin-17 antagonism inhibits acute but not chronic vascular rejection. Tang, J.L., Subbotin, V.M., Antonysamy, M.A., Troutt, A.B., Rao, A.S., Thomson, A.W. Transplantation (2001) [Pubmed]
  11. The effect of interleukin-17 on the proliferation and invasion of JEG-3 human choriocarcinoma cells. Pongcharoen, S., Niumsup, P., Sanguansermsri, D., Supalap, K., Butkhamchot, P. Am. J. Reprod. Immunol. (2006) [Pubmed]
  12. IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: synergistic or antagonist effects with IFN-gamma and TNF-alpha. Albanesi, C., Cavani, A., Girolomoni, G. J. Immunol. (1999) [Pubmed]
  13. Cutting edge: interleukin 17 signals through a heteromeric receptor complex. Toy, D., Kugler, D., Wolfson, M., Vanden Bos, T., Gurgel, J., Derry, J., Tocker, J., Peschon, J. J. Immunol. (2006) [Pubmed]
  14. Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis. Kehlen, A., Thiele, K., Riemann, D., Langner, J. Clin. Exp. Immunol. (2002) [Pubmed]
  15. Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate. Steiner, G.E., Newman, M.E., Paikl, D., Stix, U., Memaran-Dagda, N., Lee, C., Marberger, M.J. Prostate (2003) [Pubmed]
  16. Interleukin-17 stimulates chemokine (interleukin-8 and monocyte chemoattractant protein-1) secretion in human pancreatic periacinar myofibroblasts. Takaya, H., Andoh, A., Makino, J., Shimada, M., Tasaki, K., Araki, Y., Bamba, S., Hata, K., Fujiyama, Y., Bamba, T. Scand. J. Gastroenterol. (2002) [Pubmed]
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