High impact information on Itpa

• ITP and dITP exist in all cells. dITP is potentially mutagenic, and the levels of these nucleotides are controlled by inosine triphosphate pyrophosphatase (EC ) [1].
• Chromosomal mapping of enzyme loci in the domestic cat: GSR to C2, ADA and ITPA to A3, and LDHA-ACP2 to D1 [2].
• The processed Itpa gene-like sequence located on chromosome 2E1 has a complete open reading frame for exactly the same polypeptide as ITPA encoded by the type A transcript, with a polyadenylation signal [3].
• Characterization of the structure and expression of mouse Itpa gene and its related sequences in the mouse genome [3].
• However, no transcribed sequence derived from the Itpa gene-like sequence was detectable in any of the mouse tissues examined, thus naming the sequence as Itpa processed pseudogene alpha [3].

Biological context of Itpa

• In the mouse genome, we found one processed Itpa gene-like sequence and two processed Itpa pseudogenes as well as the Itpa gene itself with introns, located on chromosome 2F3, which was isolated by a retro-recombination method [3].

Anatomical context of Itpa

• Itpa mRNA was detected in all tissues examined, and its expression is especially high in the testis, brain, and thymus [3].

References