Gene Review:
ITPA - inosine triphosphatase (nucleoside...
Homo sapiens
Synonyms:
C20orf37, HLC14-06-P, ITPase, Inosine triphosphatase, Inosine triphosphate pyrophosphatase, ...
Breen,
Marinaki,
Arenas,
Hayes,
Zelinkova,
Derijks,
Stokkers,
Vogels,
van Kampen,
Curvers,
Cohn,
van Deventer,
Hommes,
Marsh,
King,
Ahluwalia,
McLeod,
Gearry,
Roberts,
Barclay,
Kennedy,
Bierau,
Bakker,
Lindhout,
van Gennip,
De Ridder,
Van Dieren,
Van Deventer,
Stokkers,
Van der Woude,
Van Vuuren,
Benninga,
Escher,
Hommes,
Shipkova,
Lorenz,
Oellerich,
Wieland,
von Ahsen,
Shichijo,
Azuma,
Komatsu,
Kawamoto,
Takedatsu,
Shomura,
Sawamizu,
Maeda,
Ito,
Itoh,
Galperin,
Moroz,
Wilson,
Murzin,
- Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase). Marinaki, A.M., Ansari, A., Duley, J.A., Arenas, M., Sumi, S., Lewis, C.M., Shobowale-Bakre, e.l.-.M., Escuredo, E., Fairbanks, L.D., Sanderson, J.D. Pharmacogenetics (2004)
- Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression. Zelinkova, Z., Derijks, L.J., Stokkers, P.C., Vogels, E.W., van Kampen, A.H., Curvers, W.L., Cohn, D., van Deventer, S.J., Hommes, D.W. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. (2006)
- Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study. von Ahsen, N., Armstrong, V.W., Behrens, C., von Tirpitz, C., Stallmach, A., Herfarth, H., Stein, J., Bias, P., Adler, G., Shipkova, M., Oellerich, M., Kruis, W., Reinshagen, M. Clin. Chem. (2005)
- Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine. Gearry, R.B., Roberts, R.L., Barclay, M.L., Kennedy, M.A. Pharmacogenetics (2004)
- Calcium ion-insensitive contraction of glycerinated porcine cardiac muscle fibers by Mg-inosine triphosphate. ITP as a tool to dissociate the contraction mechanism from the regulatory mechanism. Toyo-oka, T. Circ. Res. (1981)
- Crystal Structure of Human Inosine Triphosphatase: SUBSTRATE BINDING AND IMPLICATION OF THE INOSINE TRIPHOSPHATASE DEFICIENCY MUTATION P32T. Stenmark, P., Kursula, P., Flodin, S., Gräslund, S., Landry, R., Nordlund, P., Schüler, H. J. Biol. Chem. (2007)
- Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis. Wessels, J.A., Kooloos, W.M., Jonge, R.D., De Vries-Bouwstra, J.K., Allaart, C.F., Linssen, A., Collee, G., Sonnaville, P.D., Lindemans, J., Huizinga, T.W., Guchelaar, H.J. Arthritis Rheum. (2006)
- Pharmacogenetics of thiopurine therapy in paediatric IBD patients. De Ridder, L., Van Dieren, J.M., Van Deventer, H.J., Stokkers, P.C., Van der Woude, J.C., Van Vuuren, A.J., Benninga, M.A., Escher, J.C., Hommes, D.W. Aliment. Pharmacol. Ther. (2006)
- ITPA genotyping test does not improve detection of Crohn's disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression. Allorge, D., Hamdan, R., Broly, F., Libersa, C., Colombel, J.F. Gut (2005)
- Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency. Sumi, S., Marinaki, A.M., Arenas, M., Fairbanks, L., Shobowale-Bakre, M., Rees, D.C., Thein, S.L., Ansari, A., Sanderson, J., De Abreu, R.A., Simmonds, H.A., Duley, J.A. Hum. Genet. (2002)
- Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation. Breen, D.P., Marinaki, A.M., Arenas, M., Hayes, P.C. Liver Transpl. (2005)
- Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene. Lin, S., McLennan, A.G., Ying, K., Wang, Z., Gu, S., Jin, H., Wu, C., Liu, W., Yuan, Y., Tang, R., Xie, Y., Mao, Y. J. Biol. Chem. (2001)
- Assignment of ADA, ITPA, AK1, and AK2 to Chinese hamster chromosomes. Genetic and structural evidence for the conservation of mammalian autosomal synteny. Stallings, R.L., Siciliano, M.J. J. Hered. (1982)
- Measurement of erythrocyte inosine triphosphate pyrophosphohydrolase (ITPA) activity by HPLC and correlation of ITPA genotype-phenotype in a Caucasian population. Shipkova, M., Lorenz, K., Oellerich, M., Wieland, E., von Ahsen, N. Clin. Chem. (2006)
- Regional assignment of ADA and ITPA to mouse chromosome 2 (C1----ter). A demonstration of the conserved linkage of enzyme and proto-oncogene loci. Siciliano, M.J., Fournier, R.E., Stallings, R.L. J. Hered. (1984)
- Identification of two novel tumor-associated antigens recognized by HLA-B46-restricted cytotoxic T lymphocytes. Shichijo, S., Azuma, K., Komatsu, N., Kawamoto, N., Takedatsu, H., Shomura, H., Sawamizu, H., Maeda, Y., Ito, M., Itoh, K. Int. J. Mol. Med. (2003)
- Human inosine triphosphatase: catalytic properties and population studies. Holmes, S.L., Turner, B.M., Hirschhorn, K. Clin. Chim. Acta (1979)
- Distribution of ITPA P32T alleles in multiple world populations. Marsh, S., King, C.R., Ahluwalia, R., McLeod, H.L. J. Hum. Genet. (2004)
- DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency. Cao, H., Hegele, R.A. J. Hum. Genet. (2002)
- House cleaning, a part of good housekeeping. Galperin, M.Y., Moroz, O.V., Wilson, K.S., Murzin, A.G. Mol. Microbiol. (2006)
- Inosine triphosphate pyrophosphohydrolase deficiency in a kindred with adenosine deaminase deficiency. Duley, J.A., Simmonds, H.A., Hopkinson, D.A., Levinsky, R.J. Clin. Chim. Acta (1990)
- Determination of ITPase Activity in Erythrocyte Lysates Obtained for Determination of Tpmt Activity. Bierau, J., Bakker, J.A., Lindhout, M., van Gennip, A.H. Nucleosides Nucleotides Nucleic Acids (2006)