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Gene Review

Klrb1a  -  killer cell lectin-like receptor subfamily...

Mus musculus

Synonyms: CD161 antigen-like family member A, Killer cell lectin-like receptor subfamily B member 1A, Ly-55A, Ly55, Ly55a, ...
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High impact information on Klrb1a

  • CD161 (NKR-P1A) costimulation of CD1d-dependent activation of human T cells expressing invariant V alpha 24 J alpha Q T cell receptor alpha chains [1].
  • The mouse NKR-P1 family includes at least three genes: NKR-P1A, -B, -C [2].
  • 3.2.3 is a mouse IgG1kappa monoclonal antibody (mAb) directed against NKR-P1A on rat NK cells [3].
  • Octavalent polyamidoamine dendrimers functionalized with N-acetyl-glucosamine residues (PAMAM-GlcNAc8), with in vitro high affinity for the recombinant lymphocyte receptor NKR-P1A, were employed [4].
  • However, other clones lacking NKR-P1A produced message for NKR-P1D [5].

Biological context of Klrb1a


Anatomical context of Klrb1a


Analytical, diagnostic and therapeutic context of Klrb1a


  1. CD161 (NKR-P1A) costimulation of CD1d-dependent activation of human T cells expressing invariant V alpha 24 J alpha Q T cell receptor alpha chains. Exley, M., Porcelli, S., Furman, M., Garcia, J., Balk, S. J. Exp. Med. (1998) [Pubmed]
  2. The NKR-P1B gene product is an inhibitory receptor on SJL/J NK cells. Kung, S.K., Su, R.C., Shannon, J., Miller, R.G. J. Immunol. (1999) [Pubmed]
  3. Importance of natural killer cells in the rejection of hamster skin xenografts. Gourlay, W.A., Chambers, W.H., Monaco, A.P., Maki, T. Transplantation (1998) [Pubmed]
  4. Effects of N-acetyl-glucosamine-coated glycodendrimers as biological modulators in the B16F10 melanoma model in vivo. Vannucci, L., Fiserová, A., Sadalapure, K., Lindhorst, T.K., Kuldová, M., Rossmann, P., Horváth, O., Kren, V., Krist, P., Bezouska, K., Luptovcová, M., Mosca, F., Pospísil, M. Int. J. Oncol. (2003) [Pubmed]
  5. NKR-P1dim/TCR alpha beta + T cells and natural killer cells share expression of NKR-P1A and NKR-P1D. Appasamy, P.M., Kenniston, T.W., Brissette-Storkus, C.S., Chambers, W.H. Nat. Immun. (1996) [Pubmed]
  6. The Cmv1 host resistance locus is closely linked to the Ly49 multigene family within the natural killer cell gene complex on mouse chromosome 6. Forbes, C.A., Brown, M.G., Cho, R., Shellam, G.R., Yokoyama, W.M., Scalzo, A.A. Genomics (1997) [Pubmed]
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