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Gene Review:

Klrb1b - killer cell lectin-like receptor subfamily...

Mus musculus

Synonyms: CD161 antigen-like family member B, Inhibitory receptor NKR-P1B, Killer cell lectin-like receptor subfamily B member 1B allele A, Killer cell lectin-like receptor subfamily B member 1B allele B, Klrb1d, ...

Appasamy, P.M. et al., Iizuka, K. et al., Gange, C.T. et al.

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High impact information on Klrb1d

Nkrp1d mediated inhibition when recognizing Clrb, a molecule expressed in dendritic cells and macrophages [1].
Unlike other NKC-encoded receptors that recognize molecules with major histocompatibility complex (MHC) class I folds, here we show that mouse Nkrp1d and Nkrp1f bind specific C-type lectin-related (Clr) molecules [1].
OCIL is a member of the natural killer cell receptor C-type lectin group that includes CD69 and NKRP1D [2].
Osteoclast inhibitory lectin (OCIL) is a membrane-bound C-type lectin that blocks osteoclast differentiation and, via binding to its cognate receptor NKRP1D, inhibits natural killer cell-mediated cytotoxicity [2].
However, other clones lacking NKR-P1A produced message for NKR-P1D [3].

Anatomical context of Klrb1d

Some NK cell clones coexpressed NKR-P1A and NKR-P1D [3].
Transcripts for NKR-P1A (1.1 kb) and NKR-P1D (2.0 kb) were produced by NK cells and NKR-P1dim/TCR alpha beta + T cells [3].

Analytical, diagnostic and therapeutic context of Klrb1d

Also, sequencing of polymerase chain reaction products derived from these populations indicated expression of a novel form, termed NKR-P1D, with approximately 60% nucleotide homology to NKR-P1A [3].

References

Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors. Iizuka, K., Naidenko, O.V., Plougastel, B.F., Fremont, D.H., Yokoyama, W.M. Nat. Immunol. (2003) [Pubmed]
Characterization of sugar binding by osteoclast inhibitory lectin. Gange, C.T., Quinn, J.M., Zhou, H., Kartsogiannis, V., Gillespie, M.T., Ng, K.W. J. Biol. Chem. (2004) [Pubmed]
NKR-P1dim/TCR alpha beta + T cells and natural killer cells share expression of NKR-P1A and NKR-P1D. Appasamy, P.M., Kenniston, T.W., Brissette-Storkus, C.S., Chambers, W.H. Nat. Immun. (1996) [Pubmed]

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KLRB1	Bos taurus
LOC100138381	Bos taurus
KLRB1	Canis lupus familiaris
KLRB1	Homo sapiens
LOC100430783	Macaca mulatta
Klrb1c	Mus musculus
Klrb1a	Mus musculus
KLRB1	Pan troglodytes
Klrb1a	Rattus norvegicus
Klrb1b	Rattus norvegicus

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