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Gene Review

Klrb1c  -  killer cell lectin-like receptor subfamily...

Mus musculus

Synonyms: AI462337, CD161, CD161 antigen-like family member C, Killer cell lectin-like receptor subfamily B member 1C, Ly-55c, ...
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Disease relevance of Klrb1c


Psychiatry related information on Klrb1c


High impact information on Klrb1c

  • One type of surface receptor such as the NKR-P1 molecule may activate NK activity whereas the other, represented by the mouse Ly-49 molecule, may engage target cell MHC molecules and inhibit cytotoxicity by transducing "negative" signals [7].
  • The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex [7].
  • A lymphocyte subpopulation, the Valpha14 natural killer T (NKT) cells, expresses both NK1.1 and a single invariant T cell receptor encoded by the Valpha14 and Jalpha281 gene segments [8].
  • CD1-deficient mice have normal numbers of CD4+ and CD8+ T cells but marked reduction in NK1.1-bearing T cells, particularly those with a canonical gene rearrangement of V alpha14-J alpha281 [9].
  • Nkrp1 (official gene name, Klrb1) and Clr are intertwined in a genetically conserved NKC region showing recombination suppression, reminiscent of plant self-incompatibility loci [10].

Biological context of Klrb1c


Anatomical context of Klrb1c


Associations of Klrb1c with chemical compounds

  • Here, we demonstrate that both NKR-P1B and NKR-P1C associate with the tyrosine kinase, p56(lck) [16].
  • Spleen virus titers were significantly augmented in B6 (NK1.1+) mice depleted of asialo GM1+ or NK1.1+ cells, whereas spleen virus titers were unaffected in D2 (NK1.1-) mice depleted of asialo GM1+ cells [17].
  • We recently reported that IL-7 preferentially promotes the in vitro expansion of a discrete MHC class I-dependent lymphocyte subset comprising both CD4+ and CD4-CD8- TCR alpha beta + cells bearing several NK cells markers such NK1.1 and Ly-49 [18].
  • With two other targets, E male G2 and RBL-5, neither serum produced significant depletion of activity, Analysis of SC indirectly labeled with either NK-1.1 or NK-2.1 antiserum and fluorescein-labeled goat anti-mouse Ig, however, did not detect significant differences between NK-1+ and NK-2+ cell populations [19].
  • These findings demonstrate that the development of NK1.1+ TCR-alpha/beta+ thymocytes is accomplished under the influence not only of BM-derived components, but also of irradiation-resistant or deoxyguanosine-resistant components and an intact microenvironment of the thymus [20].

Regulatory relationships of Klrb1c


Other interactions of Klrb1c

  • Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function [26].
  • Strikingly, engagement of NKR-P1C on NK cells obtained from Lck-deficient mice failed to induce NK cytotoxicity [16].
  • The mouse NKR-P1 family includes at least three genes: NKR-P1A, -B, -C [27].
  • Collectively, our data indicate that "NK-like" T cells develop normally in SJL mice despite genetically distinct defects in NK1.1 expression and inducible IL-4 production [12].
  • Allelic divergence of the Nkrp1b/c gene products and limited divergence of the BALB/c Nkrp1-Ocil/Clr region explain a longstanding confusion regarding the strain-specific NK1.1 alloantigen reactivity of mouse NK cells [11].

Analytical, diagnostic and therapeutic context of Klrb1c


  1. Emergence of CD8+ T cells expressing NK cell receptors in influenza A virus-infected mice. Kambayashi, T., Assarsson, E., Michaëlsson, J., Berglund, P., Diehl, A.D., Chambers, B.J., Ljunggren, H.G. J. Immunol. (2000) [Pubmed]
  2. Immunosuppressive activity of cloned natural killer (NK1.1+) T cells established from murine tumor-infiltrating lymphocytes. Tamada, K., Harada, M., Abe, K., Li, T., Tada, H., Onoe, Y., Nomoto, K. J. Immunol. (1997) [Pubmed]
  3. Studies on natural killer (NK) cells IV NK-3.1: a new NK cell specific alloantigen. Burton, R.C., Smart, Y.C., Thorn, R., Winn, H.J. Immunol. Cell Biol. (1989) [Pubmed]
  4. c-kit+ stem cells and thymocyte precursors in the livers of adult mice. Watanabe, H., Miyaji, C., Seki, S., Abo, T. J. Exp. Med. (1996) [Pubmed]
  5. The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion. Wilson, M.T., Johansson, C., Olivares-Villagómez, D., Singh, A.K., Stanic, A.K., Wang, C.R., Joyce, S., Wick, M.J., Van Kaer, L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  6. The modulation of B16BL6 melanoma metastasis is not directly mediated by cytolytic activity of natural killer cells in alcohol-consuming mice. Spitzer, J.H., Núñez, N.P., Meadows, S.A., Gallucci, R.M., Blank, S.E., Meadows, G.G. Alcohol. Clin. Exp. Res. (2000) [Pubmed]
  7. The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Yokoyama, W.M., Seaman, W.E. Annu. Rev. Immunol. (1993) [Pubmed]
  8. Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors. Cui, J., Shin, T., Kawano, T., Sato, H., Kondo, E., Toura, I., Kaneko, Y., Koseki, H., Kanno, M., Taniguchi, M. Science (1997) [Pubmed]
  9. Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice. Chen, Y.H., Chiu, N.M., Mandal, M., Wang, N., Wang, C.R. Immunity (1997) [Pubmed]
  10. Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors. Iizuka, K., Naidenko, O.V., Plougastel, B.F., Fremont, D.H., Yokoyama, W.M. Nat. Immunol. (2003) [Pubmed]
  11. Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of mouse NK cells. Carlyle, J.R., Mesci, A., Ljutic, B., Belanger, S., Tai, L.H., Rousselle, E., Troke, A.D., Proteau, M.F., Makrigiannis, A.P. J. Immunol. (2006) [Pubmed]
  12. Natural killer-like T cells develop in SJL mice despite genetically distinct defects in NK1.1 expression and in inducible interleukin-4 production. Beutner, U., Launois, P., Ohteki, T., Louis, J.A., MacDonald, H.R. Eur. J. Immunol. (1997) [Pubmed]
  13. Murine natural killer cells express functional Fc gamma receptor II encoded by the Fc gamma R alpha gene. Perussia, B., Tutt, M.M., Qiu, W.Q., Kuziel, W.A., Tucker, P.W., Trinchieri, G., Bennett, M., Ravetch, J.V., Kumar, V. J. Exp. Med. (1989) [Pubmed]
  14. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. Matsuda, J.L., Naidenko, O.V., Gapin, L., Nakayama, T., Taniguchi, M., Wang, C.R., Koezuka, Y., Kronenberg, M. J. Exp. Med. (2000) [Pubmed]
  15. Mouse NKR-P1. A family of genes selectively coexpressed in adherent lymphokine-activated killer cells. Giorda, R., Trucco, M. J. Immunol. (1991) [Pubmed]
  16. Functional requirements for signaling through the stimulatory and inhibitory mouse NKR-P1 (CD161) NK cell receptors. Ljutic, B., Carlyle, J.R., Filipp, D., Nakagawa, R., Julius, M., Zúñiga-Pflücker, J.C. J. Immunol. (2005) [Pubmed]
  17. Innate resistance to lethal mousepox is genetically linked to the NK gene complex on chromosome 6 and correlates with early restriction of virus replication by cells with an NK phenotype. Delano, M.L., Brownstein, D.G. J. Virol. (1995) [Pubmed]
  18. IL-7 reverses NK1+ T cell-defective IL-4 production in the non-obese diabetic mouse. Gombert, J.M., Tancrède-Bohin, E., Hameg, A., Leite-de-Moraes, M.C., Vicari, A., Bach, J.F., Herbelin, A. Int. Immunol. (1996) [Pubmed]
  19. Murine NK cell heterogeneity: subpopulations of C57BL/6 splenic NK cells detected by NK-1.1 and NK-2.1 antisera. Emmons, S.L., Pollack, S.B. Nat. Immun. Cell Growth Regul. (1985) [Pubmed]
  20. Generation of NK1.1+ T cell antigen receptor alpha/beta+ thymocytes associated with intact thymic structure. Nakagawa, K., Iwabuchi, K., Ogasawara, K., Ato, M., Kajiwara, M., Nishihori, H., Iwabuchi, C., Ishikura, H., Good, R.A., Onoé, K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  21. Thymus-dependent modulation of Ly49 inhibitory receptor expression on NK1.1+gamma/delta T cells. Hara, T., Nishimura, H., Hasegawa, Y., Yoshikai, Y. Immunology (2001) [Pubmed]
  22. Synergistic proliferation and activation of natural killer cells by interleukin 12 and interleukin 18. Lauwerys, B.R., Renauld, J.C., Houssiau, F.A. Cytokine (1999) [Pubmed]
  23. The emergence of non-cytolytic NK1.1+ T cells in the long-term culture of murine tumour-infiltrating lymphocytes: a possible role of transforming growth factor-beta. Tamada, K., Harada, M., Ito, O., Takenoyama, M., Mori, T., Matsuzaki, G., Nomoto, K. Immunology (1996) [Pubmed]
  24. Flt-3 ligand (FL) drives differentiation of rat bone marrow-derived dendritic cells expressing OX62 and/or CD161 (NKR-P1). Brissette-Storkus, C.S., Kettel, J.C., Whitham, T.F., Giezeman-Smits, K.M., Villa, L.A., Potter, D.M., Chambers, W.H. J. Leukoc. Biol. (2002) [Pubmed]
  25. Activation of CD1d-independent NK1.1+ T cells in the large intestine by Lactobacilli. Takahashi, S., Kawamura, T., Kanda, Y., Taniguchi, T., Nishizawa, T., Iiai, T., Hatakeyama, K., Abo, T. Immunol. Lett. (2006) [Pubmed]
  26. Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function. Carlyle, J.R., Martin, A., Mehra, A., Attisano, L., Tsui, F.W., Zúñiga-Pflücker, J.C. J. Immunol. (1999) [Pubmed]
  27. The NKR-P1B gene product is an inhibitory receptor on SJL/J NK cells. Kung, S.K., Su, R.C., Shannon, J., Miller, R.G. J. Immunol. (1999) [Pubmed]
  28. An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes. Dissen, E., Ryan, J.C., Seaman, W.E., Fossum, S. J. Exp. Med. (1996) [Pubmed]
  29. Genomic structure and strain-specific expression of the natural killer cell receptor NKR-P1. Giorda, R., Weisberg, E.P., Ip, T.K., Trucco, M. J. Immunol. (1992) [Pubmed]
  30. Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules. Ryan, J.C., Turck, J., Niemi, E.C., Yokoyama, W.M., Seaman, W.E. J. Immunol. (1992) [Pubmed]
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