Gene Review:
Cdk2 - cyclin dependent kinase 2
Rattus norvegicus
Synonyms:
Cdkn2, Cell division protein kinase 2, Cyclin-dependent kinase 2
- Cdc2 and Cdk2 kinase activated by transforming growth factor-beta1 trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells. Choi, K.S., Eom, Y.W., Kang, Y., Ha, M.J., Rhee, H., Yoon, J.W., Kim, S.J. J. Biol. Chem. (1999)
- Gastric mucosal cell cycle regulation with ulcer healing by sulglycotide. Slomiany, B.L., Piotrowski, J., Slomiany, A. Scand. J. Gastroenterol. (1997)
- Constitutive overexpression of CDK2 inhibits neuronal differentiation of rat pheochromocytoma PC12 cells. Dobashi, Y., Kudoh, T., Matsumine, A., Toyoshima, K., Akiyama, T. J. Biol. Chem. (1995)
- Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist. Pippin, J.W., Qu, Q., Meijer, L., Shankland, S.J. J. Clin. Invest. (1997)
- Deregulated cyclin E induces chromosome instability. Spruck, C.H., Won, K.A., Reed, S.I. Nature (1999)
- C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. Wang, H., Iakova, P., Wilde, M., Welm, A., Goode, T., Roesler, W.J., Timchenko, N.A. Mol. Cell (2001)
- Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27(Kip1). Hiromura, K., Pippin, J.W., Fero, M.L., Roberts, J.M., Shankland, S.J. J. Clin. Invest. (1999)
- Downregulation of cyclin-dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery. Chen, D., Krasinski, K., Sylvester, A., Chen, J., Nisen, P.D., Andrés, V. J. Clin. Invest. (1997)
- Cell cycle progression during gastric ulcer healing by ebrotidine and sucralfate. Slomiany, B.L., Piotrowski, J., Slomiany, A. Gen. Pharmacol. (1997)
- Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation. Deed, R.W., Hara, E., Atherton, G.T., Peters, G., Norton, J.D. Mol. Cell. Biol. (1997)
- E1A can provoke G1 exit that is refractory to p21 and independent of activating cdk2. Akli, S., Zhan, S., Abdellatif, M., Schneider, M.D. Circ. Res. (1999)
- Nitric oxide-induced downregulation of Cdk2 activity and cyclin A gene transcription in vascular smooth muscle cells. Guo, K., Andrés, V., Walsh, K. Circulation (1998)
- Activation of cyclin-dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes. Geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E gene expression. Tanaka, T., Tatsuno, I., Noguchi, Y., Uchida, D., Oeda, T., Narumiya, S., Yasuda, T., Higashi, H., Kitagawa, M., Nakayama, K., Saito, Y., Hirai, A. J. Biol. Chem. (1998)
- Characterization of Cdk2-cyclin E complexes in plasma membrane and endosomes of liver parenchyma. Insulin-dependent regulation. Gaulin, J.F., Fiset, A., Fortier, S., Faure, R.L. J. Biol. Chem. (2000)
- The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein. Geisen, C., Moroy, T. J. Biol. Chem. (2002)
- Differential regulation of p27(Kip1) expression by mitogenic and hypertrophic factors: Involvement of transcriptional and posttranscriptional mechanisms. Servant, M.J., Coulombe, P., Turgeon, B., Meloche, S. J. Cell Biol. (2000)
- Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases. Blomberg, I., Hoffmann, I. Mol. Cell. Biol. (1999)
- Blunted DNA synthesis and delayed S-phase entry following inhibition of Cdk2 activity in the regenerating rat liver. Stärkel, P., De Saeger, C., Sempoux, C., Legrand, E., Leclercq, I., Horsmans, Y. Lab. Invest. (2005)
- Aging enhances G(1) phase in the colonic mucosa of rats. Xiao, Z.Q., Jaszewski, R., Majumdar, A.P. Mech. Ageing Dev. (2000)
- Impairments in both p70 S6 kinase and extracellular signal-regulated kinase signaling pathways contribute to the decline in proliferative capacity of aged hepatocytes. Liu, Y., Gorospe, M., Kokkonen, G.C., Boluyt, M.O., Younes, A., Mock, Y.D., Wang, X., Roth, G.S., Holbrook, N.J. Exp. Cell Res. (1998)
- The mycotoxin fumonisin B1 transcriptionally activates the p21 promoter through a cis-acting element containing two Sp1 binding sites. Zhang, Y., Dickman, M.B., Jones, C. J. Biol. Chem. (1999)
- Mechanism of activation of ERK2 by dual phosphorylation. Prowse, C.N., Lew, J. J. Biol. Chem. (2001)
- Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27(Kip1) binding to newly formed complexes. Pérez-Roger, I., Solomon, D.L., Sewing, A., Land, H. Oncogene (1997)
- Mechanisms underlying maintenance of smooth muscle cell quiescence in rat aorta: role of the cyclin dependent kinases and their inhibitors. Izzard, T.D., Taylor, C., Birkett, S.D., Jackson, C.L., Newby, A.C. Cardiovasc. Res. (2002)
- Changes in cyclin dependent kinase expression and activity accompanying lens fiber cell differentiation. Gao, C.Y., Rampalli, A.M., Cai, H.C., He, H.Y., Zelenka, P.S. Exp. Eye Res. (1999)
- All-trans retinoic acid inhibits vascular smooth muscle cell proliferation targeting multiple genes for cyclins and cyclin-dependent kinases. Kosaka, C., Sasaguri, T., Komiyama, Y., Takahashi, H. Hypertens. Res. (2001)
- A variant form of cyclin-dependent kinase 2 (Cdk2) in a malignantly transformed rat thyroid (FRTL-Tc) cell line. Kotani, S., Endo, T., Kitagawa, M., Higashi, H., Onaya, T. Oncogene (1995)
- Retinoic acid-induced proliferation of lung alveolar epithelial cells is linked to p21(CIP1) downregulation. Nabeyrat, E., Corroyer, S., Epaud, R., Besnard, V., Cazals, V., Clement, A. Am. J. Physiol. Lung Cell Mol. Physiol. (2000)
- Cell cycle-mediated regulation of hepatic regeneration. Ehrenfried, J.A., Ko, T.C., Thompson, E.A., Evers, B.M. Surgery (1997)