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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

gly-2  -  Protein GLY-2

Caenorhabditis elegans

 
 
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High impact information on gly-2

  • Green fluorescent protein reporter transgenes driven by the gly-2 promoter were expressed by developing embryos from the late comma stage onward, present in a complex subset of neurons in larvae and, in addition, the spermathecal and pharyngeal-intestinal valves and certain vulval cells of adults [1].
  • The Caenorhabditis elegans genome contains a single orthologous gene, gly-2, that is transcribed and encodes a 669-residue type II membrane protein that is 36.7% identical to mammalian GlcNAc-TV (Mgat-5) [1].
  • However, no overt phenotypes were observed in animals homozygous for deletion alleles of gly-2 [1].
  • Similar alterations of glycosylation-related gene expression were also observed in mast-cell-deficient Ws/Ws rats, suggesting that mast cells in the epithelium are not relevant to the upregulation of these genes [2].

References

  1. The Caenorhabditis elegans gene, gly-2, can rescue the N-acetylglucosaminyltransferase V mutation of Lec4 cells. Warren, C.E., Krizus, A., Roy, P.J., Culotti, J.G., Dennis, J.W. J. Biol. Chem. (2002) [Pubmed]
  2. Altered expression of goblet cell- and mucin glycosylation-related genes in the intestinal epithelium during infection with the nematode Nippostrongylus brasiliensis in rat. Yamauchi, J., Kawai, Y., Yamada, M., Uchikawa, R., Tegoshi, T., Arizono, N. APMIS (2006) [Pubmed]
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